Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition.

Gabor, Christopher; Phan, Anna; Clipperton-Allen, Amy E.; Kavaliers, Martin; Choleris, Elena

doi:10.1037/a0026464

Cited by 186 publications

(147 citation statements)

References 135 publications

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“…Despite the intuitive conception that social recognition memory should not be different from any other type of memory, a large body of studies shows that it is mediated by a dedicated brain neuronal network and regulated by molecules which act specifically to modulate this type of memory (for several recent papers reviewing this issue see Gabor, Phan, Clipperton-Allen, Kavaliers, & Choleris, 2012;Harony & Wagner, 2010;Wacker & Ludwig, 2012). The most convincing evidence for this conclusion came from experiments with genetically modified mice in which the neurohypophyseal hormones oxytocin and vasopressin were manipulated.…”

Section: Neural and Molecular Mechanisms Underlying Social Recognitiomentioning

confidence: 98%

The effects of acute social isolation on long-term social recognition memory

Leser

Wagner

2015

Neurobiology of Learning and Memory

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Section: Neural and Molecular Mechanisms Underlying Social Recognitiomentioning

confidence: 98%

The effects of acute social isolation on long-term social recognition memory

Leser

Wagner

2015

Neurobiology of Learning and Memory

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“…Evidence that links estrogen to the neuropeptide oxytocin (OT), a key player in the processing of socially relevant information such as faces or voices (Averbeck, 2010;Ebstein, Israel, Chew, Zhong & Knafo 2010), offers a potential mechanism underlying these effects. By stimulating the release of OT and the transcription of OT receptor genes, estrogen allows the OT system to become more active (Gabor, Phan, Clipperton-Allen, Kavaliers & Choleris 2012;Lischke et al, 2012). Perhaps due to differences in the significance of both estrogen and OT in male and female bodies, the relationship between estrogen and voice processing is stronger in women than in men (but see Schirmer, Escoffier, Li, Li, Strafford-Wilson and Li 2008a).…”

Section: Individual Differencesmentioning

confidence: 99%

Vocal emotions influence verbal memory: Neural correlates and interindividual differences

Schirmer

Chen

Ching

et al. 2012

Cogn Affect Behav Neurosci

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Past research has identified an event-related potential (ERP) marker for vocal emotional encoding and has highlighted vocal-processing differences between male and female listeners. We further investigated this ERP vocal-encoding effect in order to determine whether it predicts voice-related changes in listeners' memory for verbal interaction content. Additionally, we explored whether sex differences in vocal processing would affect such changes. To these ends, we presented participants with a series of neutral words spoken with a neutral or a sad voice. The participants subsequently encountered these words, together with new words, in a visual word recognition test. In addition to making old/new decisions, the participants rated the emotional valence of each test word. During the encoding of spoken words, sad voices elicited a greater P200 in the ERP than did neutral voices. While the P200 effect was unrelated to a subsequent recognition advantage for test words previously heard with a neutral as compared to a sad voice, the P200 did significantly predict differences between these words in a concurrent late positive ERP component. Additionally, the P200 effect predicted voice-related changes in word valence. As compared to words studied with a neutral voice, words studied with a sad voice were rated more negatively, and this rating difference was larger, the larger the P200 encoding effect was. While some of these results were comparable in male and female participants, the latter group showed a stronger P200 encoding effect and qualitatively different ERP responses during word retrieval. Estrogen measurements suggested the possibility that these sex differences have a genetic basis.

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“…In rodents, as well as many other species, the primary cues used in this recognition process are olfactory or pheromonal, but in primates visual and auditory processes are of paramount importance. Evidence is building that the neuropeptides oxytocin and arginine-vasopressin are critically involved in the development of social recognition in rodent species (3)(4)(5)(6), primates (7), and humans (8)(9)(10)(11).…”

mentioning

confidence: 99%

Common polymorphism in the oxytocin receptor gene ( OXTR ) is associated with human social recognition skills

Skuse

Lori²,

Cubells³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

188

171

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The neuropeptides oxytocin and vasopressin are evolutionarily conserved regulators of social perception and behavior. Evidence is building that they are critically involved in the development of social recognition skills within rodent species, primates, and humans. We investigated whether common polymorphisms in the genes encoding the oxytocin and vasopressin 1a receptors influence social memory for faces. Our sample comprised 198 families, from the United Kingdom and Finland, in whom a single child had been diagnosed with high-functioning autism. Previous research has shown that impaired social perception, characteristic of autism, extends to the first-degree relatives of autistic individuals, implying heritable risk. Assessments of face recognition memory, discrimination of facial emotions, and direction of gaze detection were standardized for age (7-60 y) and sex. A common SNP in the oxytocin receptor (rs237887) was strongly associated with recognition memory in combined probands, parents, and siblings after correction for multiple comparisons. Homozygotes for the ancestral A allele had impairments in the range −0.6 to −1.15 SD scores, irrespective of their diagnostic status. Our findings imply that a critical role for the oxytocin system in social recognition has been conserved across perceptual boundaries through evolution, from olfaction in rodents to visual memory in humans.A n ability to recognize individuals from the same species is a vital component of social cognitive development in both humans and other animals that live in social groups. Social memory allows the recognition of conspecifics, hence ascription of a specific identity to another individual. In turn, this permits inferences to be made about their personal characteristics and the recollection of previous encounters, thus guiding appropriate current social responses. The ability to form social memories underpins pair-bonding (1) and bonding with offspring (2). In rodents, as well as many other species, the primary cues used in this recognition process are olfactory or pheromonal, but in primates visual and auditory processes are of paramount importance. Evidence is building that the neuropeptides oxytocin and arginine-vasopressin are critically involved in the development of social recognition in rodent species (3-6), primates (7), and humans (8-11).Thus, there are conserved mammalian mechanisms by which the neuropeptides oxytocin and vasopressin influence social recognition processes in both males and females, especially recognition memory. Evidence comes from a wide range of studies over the past two decades. Could polymorphisms in genes coding for these molecules, or for their receptors, be relevant to individual differences in social perception? Social cognitive skills are highly heritable in the general population (12, 13), implying that individual differences in social cognition may be strongly influenced by corresponding individual differences in gene expression. The social implications of allelic variation in the oxytocin receptor (...

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Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition.

Cited by 186 publications

References 135 publications

The effects of acute social isolation on long-term social recognition memory

The effects of acute social isolation on long-term social recognition memory

Vocal emotions influence verbal memory: Neural correlates and interindividual differences

Common polymorphism in the oxytocin receptor gene ( OXTR ) is associated with human social recognition skills

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