“…Then many attempts have been devoted to searching for a new method to prepare nanogels without organic solvents and surfactants residues. (An, Zhao, Li, Lu, Qiu & Shea, 2015;Huang & Goh, 2000;Liao, Shao, Wang, Qiu & Lu, 2012;Lu, Hu & Schwartz, 2002) Lu et al (Lu, Hu & Schwartz, 2002) prepared hydrophilic poly(acrylic acid) (PAA) nanogels using hydroxypropylcellulose (HPC) as a template around room temperature for the first time, which was friendly to environment. Meanwhile, HPC nanogels with diameter between 150-250 nanometers using collapsed HPC as a template were also synthesized at their LCST, however, the application of prepared HPC nanogels wasn't reported.…”