Interpretation of pyuria in children with urinary tract infection

Kenosi, M; Whitla, Laura; Khan, Nurzalina; Carty, E; Coghlan, David; Nadeem, Montasser

doi:10.1111/apa.14133

Cited by 4 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…species, Pseudomonas, Klebsiella, Staphylococcus species, Streptococcus species, Chlamydia, Neisseria gonorrhea, Candida species and Mycoplasma are also involved in urinary tract infections. 5 This is an unquestionable fact that the use of antibiotic reduces the complications and mortality related to urinary tract infections in childhood. However, the overuse or misuse of antibiotics results in the antibiotic resistance in the urinary pathogens.…”

Section: Original Articlementioning

confidence: 99%

Antibiotic Sensitivity Patterns of Uropathogens in Children: The Current Trend

Najeeb

Tariq

Kanwal³

et al. 2019

JIMDC

View full text Add to dashboard Cite

Background: The emergence of antibiotic-resistant infections has led to increased health care costs and mortality among children. The purpose of this study was to determine the causative organisms responsible for urinary tract infection and their antibiotic sensitivity pattern among pediatric patients of Rawalpindi/Islamabad. Material and Methods: This cross-sectional study was carried out from June 2014 to June 2015, in the Department of Microbiology, Army Medical College, Rawalpindi, affiliated with the Military Hospital, Rawalpindi. About 270 urine samples of children with UTI were analyzed through Analytical Profile Index (API) 20E and biochemical test strips system. Their antibiotic susceptibility was determined by using standard techniques. Data were assessed and analyzed by SPSS version 17. Results: Most common uropathogen was Escherichia coli (61.48%), followed by Proteus (15.5), Klebsiella (12.3%), Pseudomonas (4.5%), Enterococcus (3.7%) and Enterobacter (2.5%). Gram-negative rods, were most sensitive to imipenem (100%), Gentamycin (86%) and Amikacin (78.3%). They were least sensitive to Ampicillin (4.2%) and Norfloxacin (5.5%). Gram-positive cocci showed highest sensitivity for Vancomycin (100%) while displayed relatively less sensitivity for Nitrofurantoin (61.2%) and Gentamycin (48.7%). Cephalosporins also showed increased resistance with only 14% of gram-negative rods showing sensitivity to Cefotaxime. These organisms were highly resistant to Penicillin, showing a sensitivity of only 12.4%. Conclusion: Decreased sensitivity against penicillin and cephalosporins is seen in uropathogens causing UTI in children. High sensitivity towards Nitrofurantoin makes this drug an empirical treatment in UTI. Regular surveillance of the developing resistance in uropathogens due to inappropriate use of antibiotic is necessary to reduce complication in children with urinary tract infection.

show abstract

Section: Original Articlementioning

confidence: 99%

Antibiotic Sensitivity Patterns of Uropathogens in Children: The Current Trend

Najeeb

Tariq

Kanwal³

et al. 2019

JIMDC

View full text Add to dashboard Cite

show abstract

Relationship between urinalysis findings and responsible pathogens in children with urinary tract infections

Ünsal

Kaman

Tanır

2019

Journal of Pediatric Urology

View full text Add to dashboard Cite

The relationship between uropathogens and clinical characteristics of children with urinary tract infection

Leventoğlu,

Soran,

Tüter Öz

et al. 2024

Health Sci. Q.

View full text Add to dashboard Cite

Urinary tract infections (UTI) are common bacterial infections in children. This study aimed to examine the relationships between different microorganisms and both clinical and laboratory findings in pediatric patients with UTIs. We conducted a retrospective evaluation of children with UTI between 2019 and 2024. Patients were divided into four main groups as normal anatomy, vesicoureteral reflux (VUR), ureteropelvic junction obstruction (UPJO), and neurogenic bladder (NB). Information on clean intermittent catheterization (CIC) and prophylactic antibiotic use was recorded. Laboratory results were compared across these patient groups. The study included 266 patients, with a female predominance (female/male ratio: 7.33). NB was the most common urinary tract condition (43.3%), followed by VUR (10.9%) and UPJO (9%). Prophylactic antibiotics were used by 9% of the patients. Acute phase reactants in patients with CIC were significantly higher (p=0.023 for white blood cell (WBC) and p=0.002 for C-reactive protein (CRP) levels). They were also higher in patients with prophylactic antibiotics compared to those without (p=0.001 for both). The most frequently detected bacteria in urine cultures were E. coli (65%), followed by Klebsiella spp. (18.8%), Pseudomonas spp. (7.5%), and Proteus spp. (4.9%). Klebsiella spp., Enterococcus spp., and Morganella spp. were not isolated from patients receiving prophylaxis (p=0.022). Risk factors for UTIs need to be carefully assessed for every patient, and treatment should be customized according to clinical and laboratory results. Individual patient factors should guide drug selection, and treatment plans should account for potential resistance patterns.

show abstract

Interpretation of pyuria in children with urinary tract infection

Cited by 4 publications

References 4 publications

Antibiotic Sensitivity Patterns of Uropathogens in Children: The Current Trend

Antibiotic Sensitivity Patterns of Uropathogens in Children: The Current Trend

Relationship between urinalysis findings and responsible pathogens in children with urinary tract infections

The relationship between uropathogens and clinical characteristics of children with urinary tract infection

Contact Info

Product

Resources

About