1973
DOI: 10.1136/bmj.4.5893.643
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Interpretation of Serum Calcium in Patients with Abnormal Serum Proteins

Abstract: SummaryTwo hundred consecutive specimens received in this laboratory for "liver function tests" showed a wide range of abnormal protein concentrations. Calcium concentration correlated closely with albumin (r = 0867) but less closely with total protein (r = 0 682). A simple formula for adjusting calcium concentration was derived from the regression equation of calcium on albumin. Adjusted calcium = calcium -albumin + 4-0, where calcium is in mg/100 ml and albumin in g/100 ml.Low calcium concentrations were fou… Show more

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Cited by 796 publications
(464 citation statements)
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“…The total serum calcium concentrations were corrected for the serum albumin concentration. 22 As surrogate parameters indicating hepatic ADEs, the changes in alanine aminotransferase, alkaline phosphatase and/or bilirubin were evaluated. Changes in the activities of liver enzymes were classified as ADEs depending on baseline values, as explained in Table 1.…”
Section: Evaluation Of Adesmentioning
confidence: 99%
“…The total serum calcium concentrations were corrected for the serum albumin concentration. 22 As surrogate parameters indicating hepatic ADEs, the changes in alanine aminotransferase, alkaline phosphatase and/or bilirubin were evaluated. Changes in the activities of liver enzymes were classified as ADEs depending on baseline values, as explained in Table 1.…”
Section: Evaluation Of Adesmentioning
confidence: 99%
“…Serum and urinary calcium, phosphorus, and creatinine were measured by a multichannel autoanalyzer. The serum calcium level was corrected for protein binding (Payne et al, 1973). Statistical analyses were performed using Student's t test.…”
Section: Analysesmentioning
confidence: 99%
“…Although a different formula for correction [total calcium + (4.0 − albumin) * 0.8] is used in Europe and the U.S., Payne's formula is commonly used in Japan for its simplicity [6].…”
Section: Introductionmentioning
confidence: 99%