Interpreting the various associations of MiRNA polymorphisms with susceptibilities of cardiovascular diseases

Zhou, Kaiyu; Peng, Yue; Yan, Hualin; Zhang, Yi; Qiu, Dajian; Hua, Yimin; Li, Yifei

doi:10.1097/md.0000000000010712

Cited by 5 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MicroRNAs (miRNAs) are endogenous, small noncoding RNAs with 18-25 nucleotides, which can transcribe from nonprotein coding genes or introns, and play multifunctional roles by regulating gene expression at a posttranscriptional level through binding to the 3′-untranslated regions of target genes [10][11][12]. Many reports have shown that proliferation and metastasis of human tumor cells are accompanied by abnormal expression of miRNAs [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

miRNA-128 modulates bone neoplasms cells proliferation and migration through the WNT/β-catenin and EMT signal pathways

Long

Wang

et al. 2021

J Orthop Surg Res

View full text Add to dashboard Cite

Background Bone neoplasms present poor prognosis due to recurrence and metastasis. Although the role microRNAs (miRNAs) in inhibiting growth and metastasis of bone neoplasms has been investigated, the underlying potential molecular mechanisms mediated by miRNA-128 (miR-218) for the invasiveness of bone neoplasms cells are still not completely understood. The purpose of this study was to identify the regulatory mechanisms of miR-218 in bone neoplasms cells. Methods Western blotting, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), Counting Kit-8 assay, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining, luciferase activity assay immunofluorescence, and immunohistochemistry were used to analyze the regulatory effects of miR-218 on bone neoplasms cells. Results Here, the results showed that transfection of miR-128 suppressed bone neoplasms cells proliferation, migration, and invasion. Genetic knockdown of miR-128 in bone neoplasms cells suppressed the activation of the Wnt/β-catenin and epithelial-mesenchymal transition (EMT) signaling pathways. Activation of Wnt or EMT blocked miR-128-inhibited cells proliferation and migration in bone neoplasms cells. Exogenously introduced miR-128 markedly inhibited tumor regeneration in bone neoplasms xenograft models. Conclusions These results define a tumor-regulated function for miR-128 in bone neoplasms by down-regulation of the Wnt/β-catenin and EMT signal pathways, which provided a potential target for bone neoplasms gene therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

miRNA-128 modulates bone neoplasms cells proliferation and migration through the WNT/β-catenin and EMT signal pathways

Long

Wang

et al. 2021

J Orthop Surg Res

View full text Add to dashboard Cite

show abstract

“…Recently, a major focus of interest has emerged on the role of microRNAs (miRNAs) as regulators of the pathophysiology of multiple cardiometabolic pathologies, including obesity, IR, atherosclerosis and heart failure [ 20 , 21 , 22 , 23 , 24 ]. There is evidence that the coordinated action of multiple miRNAs regulates multiple pathways that may converge to promote development of IR [ 25 , 26 , 27 , 28 , 29 ], T2DM and CVD [ 30 , 31 , 32 ]. Therefore, gaining insight into miRNA-mediated IR development may provide enormous potential in the prevention and early diagnosis of disease.…”

Section: Introductionmentioning

confidence: 99%

miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression

Benito‐Vicente

Uribe

Rotllan

et al. 2020

IJMS

View full text Add to dashboard Cite

Insulin resistance (IR) is one of the key contributing factors in the development of type 2 diabetes mellitus (T2DM). However, the molecular mechanisms leading to IR are still unclear. The implication of microRNAs (miRNAs) in the pathophysiology of multiple cardiometabolic pathologies, including obesity, atherosclerotic heart failure and IR, has emerged as a major focus of interest in recent years. Indeed, upregulation of several miRNAs has been associated with obesity and IR. Among them, miR-27b is overexpressed in the liver in patients with obesity, but its role in IR has not yet been thoroughly explored. In this study, we investigated the role of miR-27b in regulating insulin signaling in hepatocytes, both in vitro and in vivo. Therefore, assessment of the impact of miR-27b on insulin resistance through the hepatic tissue is of special importance due to the high expression of miR-27b in the liver together with its known role in regulating lipid metabolism. Notably, we found that miR-27b controls post-transcriptional expression of numerous components of the insulin signaling pathway including the insulin receptor (INSR) and insulin receptor substrate 1 (IRS1) in human hepatoma cells. These results were further confirmed in vivo showing that overexpression and inhibition of hepatic miR-27 enhances and suppresses hepatic INSR expression and insulin sensitivity, respectively. This study identified a novel role for miR-27 in regulating insulin signaling, and this finding suggests that elevated miR-27 levels may contribute to early development of hepatic insulin resistance.

show abstract

“…In addition, polymorphisms in miRs miR-146a, miR-499 and miR-196a have been found to impact on cardiovascular disease in a recent meta-analysis. 17 Hence, a possible bi-directional interaction between miR expression levels and cardiovascular disease status needs to be considered.…”

mentioning

confidence: 99%

You don’t know them until you challenge them – micro ribonucleic acid changes in response to acute exercise in patients with coronary artery disease

Kränkel

2018

Eur J Prev Cardiolog

View full text Add to dashboard Cite

Interpreting the various associations of MiRNA polymorphisms with susceptibilities of cardiovascular diseases

Abstract: Despite inter-study variability, the polymorphisms from miR-146a, miR-499 and miR-196a2 have impacts on cardiovascular disease. Each type of miRNA has individual role in either cardiac development or the origins of CVD.

Cited by 5 publications

References 41 publications

miRNA-128 modulates bone neoplasms cells proliferation and migration through the WNT/β-catenin and EMT signal pathways

miRNA-128 modulates bone neoplasms cells proliferation and migration through the WNT/β-catenin and EMT signal pathways

miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression

You don’t know them until you challenge them – micro ribonucleic acid changes in response to acute exercise in patients with coronary artery disease

Contact Info

Product

Resources

About