Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk

Pugeat, Michel; Moulin, Philippe; Cousin, Patrice; Fimbel, Sylvie; Nicolas, Marie Héléne; Crave, Jean-Charles; Lejeune, Hervé

doi:10.1016/0960-0760(95)00102-6

Cited by 113 publications

(69 citation statements)

References 57 publications

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“…It has been hypothesized that SHBG affects atherogenesis both directly and indirectly, through the lipoprotein Figure 3 The relationship between sex hormone-binding globulin (SHBG) and the insulin sensitivity index (ISI Matsuda) in hyperandrogenic women (nZ185). metabolism or by affecting the estradiol-testosterone balance (49). In the present study, women identified as having IR had significantly lower HDL concentrations, regardless of the calculation model used.…”

Section: Discussionmentioning

confidence: 57%

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome

Kajaia¹,

Binder²,

Dittrich³

et al. 2007

eur j endocrinol

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Background: The aim of the present study is to assess insulin resistance (IR) in women with hyperandrogenic syndrome, which was suggested to replace the term polycystic ovary syndrome by the Androgen Excess Society, and to evaluate whether sex hormone-binding globulin (SHBG) can be used as a predictive marker of IR in hyperandrogenic women. Methods: Clinical, metabolic, and endocrine parameters were measured, and an oral glucose tolerance test was carried out. The women were classified as IR group or non-IR group, in accordance with defined cutoff points for the homeostatic model assessment of IR (HOMA-IR) at R2.5, the quantitative insulin sensitivity check index at %0.33, and the Matsuda insulin sensitivity index (ISI) at %5. Results: The women classified as having IR had a significantly higher body mass index (BMI) and free androgen index (FAI) and showed significantly lower SHBG and high-density lipoprotein (HDL) levels, regardless of the indices used. However, with the Matsuda ISI, generally more women were diagnosed as having IR, and this group had significantly higher total testosterone and triglyceride values, as well as a higher incidence of hirsutism. Conclusions: Women who were classified as being insulin resistant using insulin sensitivity indices showed significantly higher BMI and FAI values and lower SHBG and HDL levels. However, the Matsuda ISI may be more favorable for identifying IR in hyperandrogenic women. SHBG may serve as a predictive marker of IR in these women, particularly in those who are obese.

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Section: Discussionmentioning

confidence: 57%

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome

Kajaia¹,

Binder²,

Dittrich³

et al. 2007

eur j endocrinol

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“…These results are consistent with several other reports showing similar correlations. 15 Multiple regression analyses to predict SHBG levels…”

Section: Resultsmentioning

confidence: 99%

Synthesis and regulation of sex hormone-binding globulin in obesity

Hautanen

2000

Int J Obes

137

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Sex hormone-binding globulin (SHBG) is a plasma glycoprotein with high binding af®nity for testosterone and dihydrotestosterone and lower af®nity for estradiol. SHBG is synthesized in the liver, and its plasma level is important in the regulation of plasma free and albumin-bound androgens and estrogens. Obesity and particularly excess visceral fat, known risk factors for cardiovascular and metabolic diseases, are associated with decreased testosterone levels in males and SHBG levels in both sexes. SHBG is usually positively correlated with high-density lipoprotein cholesterol and negatively correlated with triglyceride and insulin concentrations. A positive association between SHBG and various measures of insulin sensitivity has been demonstrated in both sexes, suggesting that decreased SHBG levels may be one of the components of the metabolic syndrome. We have examined pituitary ± adrenocortical function, glucose tolerance, and lipoprotein and hormone levels in a large cohort of Finnish males. Abdominal obesity appears to be associated with slight hypocortisolemia and increased sensitivity to exogenous adrenocorticotropin stimulation, which may contribute to the hyperinsulinemia and related metabolic changes including decreased SHBG levels in males.

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“…The independent association between SHBG and HDL 2 is related to the biosynthesis of hepatic lipase, which increases the conversion rate of HDL 2 and HDL 3 . Hepatic lipase is stimulated by androgens; thus, by regulating the androgenic milieu, SHBG acts as a modulator of hepatic lipase synthesis, which influences HDL subfractions and reduces HDL 2 (32). Furthermore, insulin is reported to directly reduce SHBG secretion from the liver (33); thus, it is not surprising that SHBG showed significant independent associations with insulin, HOMA IR, and HDL 2 beyond VAT.…”

Section: Original Articlementioning

confidence: 99%

Androgenic sex steroids contribute to metabolic risk beyond intra‐abdominal fat in overweight/obese black and white women

Perry

Wang

Goldberg

et al. 2013

Obesity

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Objective: To determine the independent contribution of androgenic sex hormones beyond visceral adipose tissue (VAT) on metabolic risk. Design and Methods: A cross-sectional evaluation of 66 (36 white and 30 black) premenopausal overweight/obese women using multiple regression analyses to determine the independent effects of sex hormone-binding globulin (SHBG), total testosterone (TT), and free testosterone using the free androgen index (FAI) on metabolic variables above VAT. Results: SHBG contributed to the variance in insulin (P ¼ 0.003), insulin resistance using HOMA-IR (P ¼ 0.006), and high-density lipoprotein cholesterol 2 (P ¼ 0.029). TT contributed to the variance in systolic and diastolic blood pressure (P < 0.001), total cholesterol (P ¼ 0.003), low-density lipoprotein cholesterol (P ¼ 0.003), and apolipoprotein B (P ¼ 0.004). FAI contributed to the variance in the greatest number of metabolic variables beyond VAT. There was also a significant race-FAI interaction for fasting glucose (P ¼ 0.013). A Pearson's correlation coefficient showed a significant relationship between FAI and glucose in white women (r ¼ 0.48, P ¼ 0.003) while showing no relationship in black women (r ¼ À0.01, P ¼ 0.941). Conclusions: Our study showed that androgenic sex steroids contributed significantly to the variance in metabolic variables associated with health risk. However, they do not provide sufficient information relevant to glucose status in black women.

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Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk

Cited by 113 publications

References 57 publications

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome

Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome

Synthesis and regulation of sex hormone-binding globulin in obesity

Androgenic sex steroids contribute to metabolic risk beyond intra‐abdominal fat in overweight/obese black and white women

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