Interrelationship of serum TSH with BMI in patients with thyroid disorders

Abstract

Introduction: The endocrine system is evaluated primarily by measuring hormone concentrations, thereby arming the clinician with valuable diagnostic information. Thyroid Hormones which increase the basal metabolic rate and thermogenesis have been reported to be one of leptins regulating factors because alterations of thyroid status might lead to compensatory changes in circulatory leptin. Aim: The aim of this study was to find the correlation of Serum TSH with BMI in patients with thyroid disorder (hypothyroidism and hyperthyroidism). Material & Methods: 30 diagnosed cases of thyroid disorders out of which 20 were of hypothyroidism and 10 were of hyperthyroidism and 30 healthy controls were recruited in our study. Serum TSH levels were estimated in both cases and controls using ELISA method. BMI was calculated using QUETLET'S index as body weight (kg) divided by height squared (m 2). Results: In our study we found a significant (p=<0.001) positive correlation (r=0.514) of TSH with BMI in hypothyroid patients whereas a non significant (p=.551) positive correlation (r=.215) was found in hyperthyroid patients. Conclusion: Even small changes in the TSH levels can have an effect on BMI profile. In hypothyroid patients there is increase in weight so increase in BMI and also increase in TSH. On the other hand in hyperthyroid individuals there is loss of weight so decrease in BMI and also decrease in TSH. But further large scale data is required to confirm our findings.