Interrelationships of Desoxycorticosterone, Cortisone and Vitamin C in the Genesis of Mesenchymal Lesions.

Schaffenburg, C. A.; Masson, G. M. C.; Corcoran, A. C.

doi:10.3181/00379727-74-17907

Cited by 30 publications

(3 citation statements)

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“…[6][7][8][9][10] brane and osteoporosis with essentially no osteoblastic activity on the alveolar bone side were found. These degenerative changes occurred most strongly in the DOCtreated scorbutic animals.…”

Section: Resultsmentioning

confidence: 99%

Periodontal Lesions in Hypercitricemia: Effect of Adrenal Cortical Hormones on the Blood Citric Acid Level and the Periodontal Tissues

1963

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It is an interesting fact that the citric acid content in blood has apparently increased in patients with advanced alveolar atrophy.1 Insofar as this hypercitricemia appears to be associated with some types of periodontal disease, it was thought to be of interest to investigate the effect of the many factors that influence the citric acid.Numerous workers have studied the effect of fluoroacetate2, 3 vitamin D,4 5 and parathyroid hormone6 on the citric acid and enzyme systems that may be concerned in the formation or destruction of citric acid. Recently, Banerjee, Biswas, and Singh7 have found that the citric acid content in the tissues has significantly increased in scurvy and that treatment with insulin in such cases has brought the level of citric acid to normal. Agrell, Lindell, and Westling8 have found that adrenalectomy has been followed by a significant increase in the citric acid content of blood serum in guinea pigs and that this increase could have been prevented by cortisone or desoxycorticosterone.However, few workers have studied in detail the effect of adrenal cortical hormone on citric acid and have observed simultaneously the periodontal tissues. This paper deals with the influence of adrenocorticotropic hormone (ACTH), cortisone, and desoxycorticosterone (DOC) on the blood citric acid content in normal and scorbutic animals. It also demonstrates the histologic changes in the periodontal tissues which acompany the changes in blood citric acid. MATERIALS AND METHODSFemale guinea pigs weighing 320-70 gm. were initially fed on a vitamin C-deficient diet, made adequate by the addition of fresh vegetables. This diet plus water was continued ad libitum for 10 days. Then they were divided into 8 groups, 4 groups continuing with the adequate diet and 4 groups restricted to the vitamin C-deficient diet. Animals in 3 groups with adequate nutrition and 3 groups on the scorbutic diet were given intraperitoneal injections of hormones each day for 17 days. The other 2 groups were continued on the respective diets only. The groups and the hormones injected were as follows-Division A = normal adequate diet: 1 no injections, 2 ACTH 5 units daily, 3 = cortisone 5 mg. daily, 4 DOC 5 mg. daily; Division B vitamin C-deficient diet: 5 = no injections, 6 ACTH 5 units daily, 7 cortisone 5 mg. daily, 8 = DOC 5 mg. daily.On the seventeenth day, the animals were allowed water but no food for 15-18 hours. Then blood was collected by heart puncture. Blood citric acid was determined

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Section: Resultsmentioning

confidence: 99%

Periodontal Lesions in Hypercitricemia: Effect of Adrenal Cortical Hormones on the Blood Citric Acid Level and the Periodontal Tissues

1963

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“…A carefully controlled study varying the stimulus and amount of hormone used is indicated. During the hyperadrenal state, the severity of the scorbutic lesion is decreased (90,144,163), this finding may be related to the discovery that during pregnancy scurvy is less severe (22). Desoxycorticosterone (DOC) increases the number of fibroblasts in a turpentine abscess (187), and an increased fibrous reaction to inflammation follows its administration (169).…”

Section: Hormonal Effectsmentioning

confidence: 97%

The Physiology of the Connective Tissue (Loose Areolar)

Ragan¹

1952

Annu. Rev. Physiol.

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“…Schaffenburg, Masson & Corcoran [1950] have found that in guinea-pigs with scurvy, the adrenal glands are hypertrophic, that the ascorbic acid content is diminished and that cortisone and ACTH abolish the symptoms of scurvy, while DCA increases them.…”

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confidence: 96%

The Effect of High Doses of Ascorbic Acid on the Functions of the Adrenal Glands

S¹

1952

J Endocrinol

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Four grams ascorbic acid given daily by mouth for 4 days increase the urinary excretion of 11-oxysteroids and decrease the excretion of 17-ketosteroids. Ascorbic acid probably acts directly on the adrenal cortex.The relations which exist between ascorbic acid and the adrenal glands have been the object of many studies. Stress, adrenaline and ACTH deplete ascorbic acid in the adrenal cortex, but the production of such an effect by stress or adrenaline requires an intact pituitary gland [Sayers & Sayers, 1948; Dury, 1948; Selye & Stone, 1950;Selye, 1950]. Selye notes that in subjects who have an intact pituitary gland, ascorbic acid decreases during the alarm reaction phase and increases during the resistance phase in the blood, that ACTH and cortical extracts increase the ascorbic acid content of the blood but have no effect on that of the tissues, and that ascorbic acid facilitates the production of the resistance phase.The therapeutic activity of ACTH increases with the rise of the ascorbic acid content of the blood [Ferstl & Heppich, 1950].The hypertrophy of the adrenal glands, which is produced in guinea-pigs and rats by exposure to cold, can be prevented, and resistance to cold be increased with high doses of ascorbic acid [Dugal & Thérien, 1949]. Schaffenburg, Masson & Corcoran [1950] have found that in guinea-pigs with scurvy, the adrenal glands are hypertrophic, that the ascorbic acid content is diminished and that cortisone and ACTH abolish the symptoms of scurvy, while DCA increases them.The purpose of this paper is to investigate the influence of high doses of ascorbic acid on the functional activities of the adrenal glands. METHODS This investigation has been carried out on eleven normal adult human subjects. In order to investigate the effect of ascorbic acid on gluco-corticoid and androgen production of the adrenal cortex, the 17-ketosteroid and 11-oxysteroid excretion in urine were determined, before and after the administration of ascorbic acid. Four grams ascorbic acid per os were given daily for 4 days and the hormone determinations made on the day preceding and on the fourth day following the administration of ascorbic acid. 11-oxysteroids were determined by the method of Talbot, Saltzman, Wixom & Wolf [1945] and 17-ketosteroids by Zimmermann's method [1944, 1946].The average normal value for 17-ketosteroid excretion in man was found to be 20 mg./24 hr. in our clinic.

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Interrelationships of Desoxycorticosterone, Cortisone and Vitamin C in the Genesis of Mesenchymal Lesions.

Cited by 30 publications

References 0 publications

Periodontal Lesions in Hypercitricemia: Effect of Adrenal Cortical Hormones on the Blood Citric Acid Level and the Periodontal Tissues

Periodontal Lesions in Hypercitricemia: Effect of Adrenal Cortical Hormones on the Blood Citric Acid Level and the Periodontal Tissues

The Physiology of the Connective Tissue (Loose Areolar)

The Effect of High Doses of Ascorbic Acid on the Functions of the Adrenal Glands

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