Interrelationships of Zinc and Copper Nutriture in the Rat

Murthy, Lalitha; Klevay, Leslie M.; Petering, Harold G.

doi:10.1093/jn/104.11.1458

Cited by 69 publications

(16 citation statements)

References 17 publications

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“…The Cu concentration found in the Cu-adequate and Cu-excess rats (without Mo) varied from approximately 100 to 150yg/g DM. A Cu concentration of 5-10 pg/g wet weight was found in the kidney by Owen (1964), and assuming a DM content of approximately zoog/kg this is in good agreement with a kidney Cu concentration of 22.3 and 24-1 ,ug/g DM in rats given 10 and 50 mg Cu/kg diet respectively (Alfaro & Heaton, 1973), and also with a maximum Cu concentration of 18.0 pg/g DM in the kidney of rats given Cu in their drinking water (Murthy et al 1974). These differences in the kidney Cu concentration might be partly explained by differences in age ) biTt the influence of the composition of the experimental diet or the characteristics of the inbred rat strain used in these experiments might be responsible for this high Cu concentration in the kidney also.…”

Section: Discussionsupporting

confidence: 66%

The influence of molybdenum on the copper metabolism of the rat at different Cu levels of the diet

Nederbragt

1980

Br J Nutr

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1.Male WAG/Cpb inbred rats fed on rations with approximately 1-5 rng copper/kg (deficient), 6.0 mg Cu/kg (adequate) and 25.0 mg Cu/kg (excess) were supplemented with varying amounts of molybdenum (0, 50, 150 and 500 mg/kg diet) and the effect on the Cu concentration of blood, plasma, liver and kidney, the caeruloplasmin activity of plasma and the Mo concentration of liver and kidney were studied.2. M o increased the Cu concentration of blood, plasma, liver and kidney and the Mo concentration of liver and kidney. 3. In the plasma of Mo-supplemented rats the presence of a Cu-containing fraction was demonstrated, the Cu of which did not react with dithiocarbamate and was not related to caeruloplasmin. The Cu in this fraction was not able to increase the caeruloplasmin activity in the plasma of Cu-deficient Mo-supplemented rats. The Cu concentration of the erythrocytes did not seem to have been increased by the Mo treatment.4. When compared to Cu-adequate rats the effect of Mo on the Cu distribution was reduced both by Cu deficiency and Cu excess. This decreased effect of Mo was explained by reduced uptake or retention of MO in the body as observed in the liver and kidney.In both ruminants and single-stomached animals (non-ruminants) molybdenum alone or in combination with sulphate interacts with copper metabolism. In ruminants Mo decreases the Cu concentration of blood and liver, an effect that is enhanced by SO,. In non-ruminants the Cu concentration of blood and liver is increased by Mo, an effect that is counteracted by SO,. In ruminants the Cu-Mo interaction may be explained by the dominating role of microbial processes in the rumen at the Mo levels commonly used in ruminant diets; it is suggested that the microbial-mediated formation of Cu-thiomolybdate complexes in the rumen prevents Cu absorption (Suttle, 1974; Dick et al. 1975). However, in sheep it has been observed that Mo has some effects comparable to those in non-ruminants. These effects are: an increase in the free plasma Cu concentration and the presence of a 'tightly' bound, non-caeruloplasmin Cu fraction (Smith et al. . 1975). This resemblance in influence of Mo on systemic Cu in ruminants and non-ruminants suggests that the effect of Mo feeding in ruminants may be the result of two interactive processes of which the first may be found in the rumen and the second (comparable to that in nonruminants) in the tissues. It was the purpose of this study to investigate the systemic effect of Mo on Cu metabolism in more detail, using rats as an animal model.

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Section: Discussionsupporting

confidence: 66%

The influence of molybdenum on the copper metabolism of the rat at different Cu levels of the diet

Nederbragt

1980

Br J Nutr

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“…Furthermore this type of interrelation has also been found in the serum of rats (Murthy et al 1974). A controversial result, compared to animal studies (Pond et al 1978, Schwarz & Kirchgessner 1979, was observed in human bone (regression coefficient between Zn and Cu was positive) when the concentrations of Zn and Cu varied within normal limits.…”

Section: Discussionmentioning

confidence: 85%

Zn and Cu Content in Human Cancellous Bone

Lappalainen

Knuuttila

Lammi

et al. 1982

Acta Orthopaedica Scandinavica

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“…The imbalance of Zn to Cu in a diet is an important aspect of growth and bone marrow development in the rat as we have previously pointed out [26]. This balance, however, does not seem to be based strictly on a ratio basis as suggested by Klevay [27,28].…”

Section: Discussionmentioning

confidence: 92%

Copper Deficiency Effects on Cardiovascular System and Lipid Metabolism in the Rat; the Role of Dietary Proteins and Excessive Zinc

et al. 1985

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Weanling rats were fed a copper-deficient purified diet. The effects of varying the type of protein and supplements of copper and zinc on cardiovascular pathology and some biochemical parameters were investigated. It was found that cardiomyopathy developed in the copper-deficient groups. Milk powder caused significant exacerbation of this development relative to dietary casein or egg white. Angiopathy developed only when dietary zinc was 20 ppm. Dietary copper did not change this situation. Serum cholesterol was elevated when copper was low and casein or milk powder were the protein source. The data point to an interaction between type of protein and dietary copper or zinc in the pathogenesis of cardiovascular lesions.

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Interrelationships of Zinc and Copper Nutriture in the Rat

Cited by 69 publications

References 17 publications

The influence of molybdenum on the copper metabolism of the rat at different Cu levels of the diet

The influence of molybdenum on the copper metabolism of the rat at different Cu levels of the diet

Zn and Cu Content in Human Cancellous Bone

Copper Deficiency Effects on Cardiovascular System and Lipid Metabolism in the Rat; the Role of Dietary Proteins and Excessive Zinc

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