Intersection Syndrome of Gastroesophageal Reflux Disease, Functional Dyspepsia and Irritable Bowel Syndrome: Pathogenetic Links and Approaches to Therapy

Дичева, Д. Т.; Andreyev, D.N.; Ulyankina, Ye.V.

doi:10.33978/2307-3586-2019-15-36-64-70

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…ГЭРБ, ФД и СРК являются одними из наиболее распространенных нозологических единиц в детской гастроэнтерологической практике [30]. Наиболее распространенными вариантами таких комбинаций являются синдром перекреста ГЭРБ и ФД, а также СРК и ФД [31,32].…”

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Оverlap-syndrome in pediatric practice

Chernenkov

Glushakov

Glushakova

et al. 2023

jour

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The problem of combined pathology in childhood has an important medical and social aspect. To date, aspects of the pathogenesis of the overlap syndrome are being considered and studied. Despite reliable data on the factors in the development of overlap syndrome in clinical practice, the eff ectiveness of diagnosis and treatment is still low. This review summarizes the current scientifi c data from epidemiological studies of various types of overlap syndrome, therapeutic approaches, and also analyzes a rare clinical case in pediatrics.The purpose of the review is to present an analysis of current literature data on the prevalence of overlap syndrome in pediatric practice.

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Оverlap-syndrome in pediatric practice

Chernenkov

Glushakov

Glushakova

et al. 2023

jour

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“…Распространённость гастроэзофагеальной рефлюксной болезни (ГЭРБ) в Российской Федерации среди взрослого населения составляет 18-46%, причем у 45-80% больных обнаруживают эзофагит [1], функциональной диспепсии (ФД) -23,4% [2], хронического гастрита 10-26% [3], синдрома раздраженного кишечника (СРК) -10-19% [4] Также отмечается частый перекрест ГЭРБ, ФД и СРК [5].…”

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Positive correlation between irregular nutrition and the incidence of gastric dyspepsia in medical students

Аксенова

Щербак

Skobova

et al. 2021

jour

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Objective. To analyze the peculiarities of eating behavior and diet of medical students, to reveal the relationship between dietary habits and gastrointestinal symptoms. Materials and methods. A one-step anonymous survey of 996 students of 1-6 grades of the Chita State Medical Academy was carried out. The author’s questionnaire contained 53 questions concerning the peculiarities of the diet, the quality of the consumed products, as well as aimed at identifying gastrointestinal symptoms and hereditary factors in students. Statistical processing was carried out using the Statistica 10.0 program, correlation analysis was carried out using gamma correlation. Results. Only 40% of the respondents eat regularly at least 3 times a day. Almost 80% of students periodically skip meals at lunchtime, replacing it with a “snack on the run”: 45% 1-2 times a week, 24.8% 3-4 times a week, 9.4% daily during the school week. A positive correlation was found between the frequency of “snacking while running” per week with the frequency of pain (p = 0.0000001) and symptoms of gastric dyspepsia (p = 0.0000001). Only 57% of the respondents have breakfast. Abdominal pain 1-2 times a month and less was in 37.6% of respondents, 1-2 times a week - 26%, 3-4 times a week and more often - 7.4% and only 22% did not complain of pain in a stomach. Conclusion. Most of students have eating disorders that include inadequate breakfast, snack instead of lunch, lunch-dinner, and eating after 22:00. The relationship between the frequencies of eating disorders, fast food consumption, chips with gastrointestinal symptoms was revealed.

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Differentiated approach to the choice of PPI in a patient with GERD in the practice of an outpatient (with a clinical case)

Pakhomova

Малко-Скрозь

2020

Medicinskij sovet

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In recent years, functional disorders of the gastrointestinal tract (GIT) are quite common. The most significant functional disorders are functional dyspepsia (FD), which is widespread in the population. In addition, in the clinical practice of outpatient doctors, the proportion of combined variants or overlap of several types of functional disorders or a combination of functional disorders with organic pathology has increased. So, according to systematic reviews, the combined course of gastroesophageal reflux disease (GERD) and FD occurs in at least one third of patients. At the same time, the combined functional pathology of the gastrointestinal tract changes the clinical picture of GERD, which complicates differential diagnosis, leads to inadequate and multiple prescription of drugs and often low effectiveness of the prescribed therapy. All this negatively affects the quality of life of patients. The tactics of managing patients with the combined course of GERD and FD sometimes presents certain difficulties, since there are no available recommendations for pathogenetic therapy and preventive measures. To date, possible links in the pathogenesis of both GERD and FD have been studied and described, which predetermine certain approaches to the treatment of various variants of these two diseases. Drug therapy for GERD includes the appointment of proton pump inhibitors (PPIs), antireflux drugs. In FD therapy, prokinetics and/or PPIs are effective. A rational approach in the treatment of the intersection of GERD and FD is the appointment of a drug with a dual mechanism of action, which contains both a prokinetic and a PPI. An example of this approach is the appointment of omeprazole and domperidone. The use of this drug is presented in a clinical case.

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Intersection Syndrome of Gastroesophageal Reflux Disease, Functional Dyspepsia and Irritable Bowel Syndrome: Pathogenetic Links and Approaches to Therapy

Cited by 8 publications

References 15 publications

Оverlap-syndrome in pediatric practice

Оverlap-syndrome in pediatric practice

Positive correlation between irregular nutrition and the incidence of gastric dyspepsia in medical students

Differentiated approach to the choice of PPI in a patient with GERD in the practice of an outpatient (with a clinical case)

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