Interstitial cells of Cajal, from structure to function

Huizinga, Jan D.; Chen, Jihong; Mikkelsen, Hanne B.; Wang, Xuan-Yu; Parsons, Sean P.; Zhu, Yong Fang

doi:10.3389/fnins.2013.00043

Cited by 17 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ICCs connect with other ICCs and smooth muscle cells through gap junctions, forming a syncytium in GI tissue [ 16 ]. ICCs were first shown to play a key role in GI motility by generating slow waves that induce rhythmic contraction in smooth muscles by Faussone Pellegrini in 1977 [ 17 ]. The most widely known mechanism for slow wave generation involves intracellular changes in Ca 2+ concentrations inside ICCs [ 11 ].…”

Section: Overview Of Icc Physiologymentioning

confidence: 99%

Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products

Joung

Choi²,

Son

2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. The pathophysiology of functional dyspepsia (FD) remains uncertain, but the interstitial cells of Cajal (ICCs), pacemakers that regulate gastrointestinal motility, are garnering attention as key modulators and therapeutic targets in FD. This review comprehensively discusses the involvement of ICCs in the pharmacologic actions of FD and as therapeutic targets for herbal products for FD. Methods. A search of the literature was performed using PubMed by pairing “interstitial cells of Cajal” with “medicinal plant, herbal medicine, phytotherapy, flavonoids, or traditional Chinese medicine (TCM).” Results. From the 55 articles screened in the initial survey, 34 articles met our study criteria. The search results showed that herbal products can directly depolarize ICCs to generate pacemaker potentials and increase the expression of c-kit and stem cell factors, helping to repair ICCs. Under certain pathological conditions, medicinal plants also protect ICCs from oxidative stress and/or inflammation-induced impairment. Two representative herbal decoctions (Banhasasim-tang, 半夏泻心汤, and Yukgunja-tang, 六君子汤) have been shown to modulate ICC functions by both clinical and preclinical data. Conclusion. This review strongly indicates the potential of herbal products to target ICCs and suggests that further ICC-based studies would be promising for the development of FD treatment agents.

show abstract

Section: Overview Of Icc Physiologymentioning

confidence: 99%

Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products

Joung

Choi²,

Son

2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…INTERSTITIAL CAJAL CELLS Interstitial cells were described a century ago by Ramon and Cajal as primitive neurons. In the period from 1900 to 1960, many light microscopy studies of these Cajal cells described some of their morphological characteristics and possible distribution and organization in plexuses in the muscular layers of the intestinal wall (Huizinga et al, 2013;Lee et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Composition and Adaptation of the Enteric Neural System in Laboratory Rodents: A Cellular Overview

Abreu

Loureiro

Soares

et al. 2022

EJBIO

View full text Add to dashboard Cite

The enteric nervous system (ENS) is a neuron network present in the digestive system. Intestinal tract anatomic differences and cellular composition in different animals can help with interaction with environmental comprehension, which is a pertinent theme in molecular and cellular neurophysiology. In mammals, ENS is not the same in all species; rodents, generally, are great models for digestive tract adaptation study in physiologic process and environmental adaptation interpretation. This study is a narrative overview that describes morphological and cellular composition characterization in rodent neural enteric systems. Interstitial Cajal cells structural characteristics; ENS embryonic cell; system adaptation mediated by fasting, acute and chronic starve; gestation and lactation; temperature and diet; parasitism and rodent caloric restriction were aborded. Seasonal or transitory changes in intestine size probably occur when connected to food quality than its availability. Changes in female intestine size are reversible and periodic, increasing during lactation rodent as an attractive model for digestive flexibility study in the intestine size adjustment area. Enteric nervous system neuron morphological classification is presented, according to digestive tract localization and animal species. In conclusion, a significant change in intestinal mass and length in different rodent species can implicate intestinal motility during and after intestinal tract injury.

show abstract

“…In the gastrointestinal tract, ICCs initiate pacemaker activity and mediate neural inputs from the enteric nerve terminals to smooth muscles. They have a significant impact on the regulation of the spontaneous rhythmic activities of the gastrointestinal smooth muscle cells (SMCs) . At the first decade of the 21st century, L.M.…”

Section: Introductionmentioning

confidence: 99%

Telocytes and interstitial cells of Cajal in the biliary system

Chen

2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

A novel type of interstitial tissue cells in the biliary tree termed telocytes (TCs), formerly known as interstitial Cajal‐like cells (ICLCs), exhibits very particular features which unequivocally distinguish these cells from interstitial cells of Cajal (ICCs) and other interstitial cell types. Current research substantiates the existence of TCs and ICCs in the biliary system (gallbladder, extrahepatic bile duct, cystic duct, common bile duct and sphincter of Oddi). Here, we review the distribution, morphology and ultrastructure of TCs and ICCs in the biliary tree, with emphasis on their presumptive roles in physiological and pathophysiological processes.

show abstract

Interstitial cells of Cajal, from structure to function

Cited by 17 publications

References 24 publications

Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products

Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products

Composition and Adaptation of the Enteric Neural System in Laboratory Rodents: A Cellular Overview

Telocytes and interstitial cells of Cajal in the biliary system

Contact Info

Product

Resources

About