Telocytes and interstitial cells of Cajal in the biliary system

Chen, Lei; Yu, Baoping

doi:10.1111/jcmm.13643

Cited by 10 publications

(10 citation statements)

References 51 publications

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“…In addition to the unique features of Tps (with a very long and very slender, moniliform appearance), more and more evidence has emerged indicating that TCs differ from intersititial cells of Cajal and other types of interstitial cells (e.g. fibroblasts, fibrocytes, fibroblast-like cells and mesenchymal cells) based on their expression of cell surface antigens and microRNA profiles, and their gene expression and proteomic signatures 1,5,6 . The shape of TCs depends upon the number of the Tps arising directly from their cell body: pyriform for one Tp, spindle for two Tps, triangular for three Tps and stellate for four or more Tps [7][8][9] .…”

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confidence: 99%

Ultrastructural and immunohistochemical characteristics of telocytes in human scalp tissue

Wang

Xiao

Zhang

et al. 2020

Sci Rep

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This study was designed to characterize the location, morphology and ultrastructure of telocytes (TCs) in human scalp tissue. After obtaining approval for this study and informed consent from the patient, a scalp specimen was obtained. the distribution and morphology of tcs in human scalp tissue was assessed by immunohistochemical staining of CD34 and CD117/c-KIT, and the ultrastructure of TCs was investigated using transmission electron microscopy (TEM). Immunohistochemical staining of CD34 revealed that TCs were located in the connective tissue of human scalp, and were concentrated around hair follicles (HFs), blood vessels, sweat glands, sebaceous glands and adipose lobules. Immunohistochemical staining of CD117 revealed that TCs were mainly located in the dermis of human scalp, surrounding the HFs and sweat glands. Under TEM, TCs were seen and confirmed by their special morphological features. These cells were spindle-shaped, had small cell bodies and long thin processes, and surrounded stem cell clusters in the bulge region of HFs. These results demonstrate that TCs in human scalp were positive for CD34 and CD117, and their strategic positioning surrounding stem cells suggests their possible involvement in local regeneration, remodeling and homeostasis of the skin.

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confidence: 99%

Ultrastructural and immunohistochemical characteristics of telocytes in human scalp tissue

Wang

Xiao

Zhang

et al. 2020

Sci Rep

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“…ICCs have also been shown to serve a key regulatory role in controlling smooth muscle contractions in the urinary tract ( 24 ). In the gallbladder, ICCs are involved in the generation and propagation of spontaneous rhythmicity and the consequent tissue motility ( 9 ). A previous study found that gallbladder ICCs were redistributed from the muscle layer to the lamina propria during cholelithiasis ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…It was hypothesized that the differences in outcomes may be attributed to the different susceptibilities of various species to high cholesterol diets. It was reported that gallbladder ICCs can form a network with each other and close contact with smooth muscle cells and nerve endings through their multiple branches ( 9 ). Moreover, it was also shown that ICCs can propagate their own rhythmic excitation or neural signals to smooth muscle cells via gap junctions ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

“…To date, ICCs have been detected in various tissues including the pancreas, heart, urinary tract and blood vessels ( 7 ). ICCs were also found to be distributed in the gallbladder wall where they are involved in modulating the excitability and motility of gallbladder smooth muscle ( 9 ). It was reported that the density and location of ICCs in the gallbladder of patients with cholelithiasis are notably altered ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Changes in the interstitial cells of Cajal in the gallbladder of guinea pigs fed a lithogenic diet

Huang

Ding

2021

Exp Ther Med

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Cholesterol cholelithiasis is a common disease and gallbladder hypomotility may underlie its pathogenesis. Interstitial cells of Cajal (ICCs) in the gallbladder serve vital roles in regulating gallbladder motility. The aim of the present study was to investigate changes in gallbladder ICCs during the development of cholesterol cholelithiasis. A total of 40 male guinea pigs were randomly assigned to four groups and fed a standard diet (SD) or lithogenic diet (LD) for 2 or 8 weeks. The LD significantly increased the total cholesterol levels in the serum and bile, as well as the serum levels of high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol after 2 and 8 weeks. The LD also significantly increased and decreased the number of gallbladder ICCs at 2 and 8 weeks, respectively, by regulating the stem cell factor/C-kit pathway. Moreover, the ultrastructure of gallbladder ICCs was significantly altered after 8 weeks, and the protein expression levels of connexin 43 in the gallbladder were differentially altered after 2 and 8 weeks. Finally, cholecystokinin receptor type A (CCK1R) expression in the gallbladder was assessed. In gallbladder ICCs, its expression was significantly increased and decreased after 2 and 8 weeks, respectively. In conclusion, these results demonstrate that the density, ultrastructure and CCK1R expression levels of gallbladder ICCs are differentially altered at various stages of cholesterol cholelithiasis progression, indicating that gallbladder ICCs may be considered a potential therapeutic target for treatment of cholesterol cholelithiasis.

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“…Calcium ions reportedly contribute to slow wave generation in individual ICCs, and inositol triphosphate receptors are upregulated in ICCs, which regulate pacing currents by regulating the release of calcium ions[ 48 ]. Therefore, a high concentration of calcium ions is necessary for spontaneous electrical activity, and a disorder in such a balance between membrane and intracytoplasmic calcium will lead to swing disorder in the membrane potential of ICLCs, thus affecting the pacing function of ICLCs[ 49 ]. Furthermore, inflammation affects the pacing activity of ICC.…”

Section: Association Between Changes In Iclcs In Gallbladder Tissue and Gallbladder Dysmotility (Figure 1)mentioning

confidence: 99%

Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells

Fu¹,

Zhao²,

Wu³

et al. 2021

WJCC

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Cholesterol gallstone (CG) is a common, frequent biliary system disease in China, with a complex and multifactorial etiology. Declined gallbladder motility reportedly contributes to CG pathogenesis. Furthermore, interstitial Cajal-like cells (ICLCs) are reportedly present in human and guinea pig gallbladder tissue. ICLCs potentially contribute to the regulation of gallbladder motility, and aberrant conditions involving the loss of ICLCs and/or a reduction in its pacing potential and reactivity to cholecystokinin may promote CG pathogenesis. This review discusses the association between ICLCs and CG pathogenesis and provides a basis for further studies on the functions of ICLCs and the etiologies of CG.

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Telocytes and interstitial cells of Cajal in the biliary system

Cited by 10 publications

References 51 publications

Ultrastructural and immunohistochemical characteristics of telocytes in human scalp tissue

Ultrastructural and immunohistochemical characteristics of telocytes in human scalp tissue

Changes in the interstitial cells of Cajal in the gallbladder of guinea pigs fed a lithogenic diet

Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells

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