Interstitial Granulomatous Dermatitis in a Patient With Lupus Erythematosus

Symmetric Violaceous Papules and Plaques in a Patient with Systemic Lupus Erythematosus

“…The pathophysiology of IGD is unclear but may be related to deposition of immune complexes . Presentation of this condition is variable, typically consisting of round to annular papules, patches, and plaques located symmetrically on the trunk and proximal extremities . Although uncommonly seen, palpable cords, known as the “rope sign,” are classically described .…”

Autoimmunity-Related Granulomatous Dermatitis in Association with Hepatitis

“…Indeed, these two conditions possibly represent a continuum or progression of a single disease process corresponding to autoimmunity-related granulomatous dermatitis (ARGD) [6, 8]. The clinical associations between ARGD, autoimmune disease and lymphoproliferative disorders have been intermixed between both IGD and PNGD diagnoses in the literature [6, 9, 10, 11, 12, 13, 14]. The underlying disorder is sometimes not diagnosed at the time of the skin manifestations [15].…”

Papulonodular mucinosis with interstitial granulomatous dermatitis‐like histological changes in a male patient with systemic lupus erythematosus

“…In contrast, interstitial granulomatous dermatitis (IGD), which is a distinct histological pattern associated with autoimmune diseases, presents with barely any mucin deposition. 3,4 A 32-year-old Japanese man presented with a 2-month history of general fatigue, pyrexia, arthralgia, hair loss and skin rashes. His past history was unremarkable.…”

“…2 Collagen degeneration and granulomatous reactions may be mediated by inflammatory cytokines, vasculopathy-induced ischemia and/or immune-complex deposition on collagen fibers. 4 The coexistence of PNM and IGD may thus reflect disease activity or the severity of SLE. This could be consistent with the fact that our patient showed severe clinical symptoms with renal, retinal and central nervous system involvement.…”