Interstitial Lung Disease Associated with Combination Chemotherapy of Oxaliplatin, 5-Fluorouracil, and Leucovorin

Park, Sul; Jung, Jae Jin; Kim, Goeng Bae; Yoon, Hyung Sik; Ko, Sang Hun; Ko, Jae Ee; Lee, Yeun Seun

doi:10.4166/kjg.2010.55.5.340

Cited by 3 publications

(1 citation statement)

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“…In our patient, the FOLFOX administration had already been discontinued, and acetylcysteine (supplying glutathione) was administered from day one in our hospital. Given that arguments linking oxaliplatin administration to glutathione depletion exist [30, 32], it seemed logical to continue glutathione supplementation because this molecule plays an important role in protecting the lungs against oxidative damage, which is a possible and probable contributing factor to the emergence of interstitial pneumonitis and subsequent evolution to pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Prognosis and treatment of FOLFOX therapy related interstitial pneumonia: a plea for multimodal immune modulating therapy in the respiratory insufficient patient

et al. 2017

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Background: The FOLFOX regimen, i.e., folinic acid (FOL), fluorouracil (F) and oxaliplatin (OX), is a drug cocktail that is used to treat gastric and colorectal cancers. Despite the concomitant improvements in response rate, duration of response and patient survival, reports of serious toxic pulmonary side effects have progressively emerged. Case presentation: We describe a patient who was treated with FOLFOX as an adjuvant to a rectosigmoidal resection of a rectosigmoidal carcinoma and who developed respiratory insufficiency requiring mechanical ventilation. Computed tomography (CT) imaging and open lung biopsy findings were compatible with interstitial pneumonia (IP). She received multimodal combination treatment (acetylcysteine, corticosteroids, immune globulins and cyclophosphamide) and survived. We performed a systematic literature search and reviewed all 45 reported cases of FOLFOX-related lung toxicity and/or pulmonary fibrosis for their clinical characteristics and their outcomes related to therapy. Conclusions: We found that for the 45 cases with available data, the median age was 70 years, and the male-female ratio was 3.5: 1. In the patients exhibiting only mild respiratory symptoms, discontinuation of the culprit drug (oxaliplatin) resulted in a 100% regression of the symptoms. However the prognosis of the respiratory insufficient patient proved to be grim: death occurred in 76.9% of the cases despite conventional treatment with corticosteroids. We therefore urge oncologists and critical care specialists not to limit their interventions to the discontinuation of chemotherapy, artificial ventilation, corticosteroids and glutathione replenishment and to consider the gradual introduction of additional immune-modulating agents whenever life-threatening respiratory symptoms in oxaliplatin-treated patients do not subside; all the more so considering the fact that our analysis showed that every patient who survived intubation and mechanical ventilation experienced a full clinical recovery.

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Section: Discussionmentioning

confidence: 99%