Interstitial Pneumonitis Following Mitozantrone, Chlorambucil and Prednisolone (MCP) Chemotherapy

Clinical Approach to the Compromised Host with Fever and Pulmonary Infiltrates

“…Other agents to which compromised patients may be exposed that may be associated with the production of either (or both) the febrile pneumonitis syndrome and chronic interstitial fibrosis include melphalan, 207 azathioprine, 208 diphenylhydantoin, 209 amitriptyline, 210 parenteral gold therapy, 211 d-penicillamine, 212 nitrofurantoin, 213 mitozantrone, 214 and amiodarone. 215 This last, a potent antiarrhythmic agent, has been a particular problem in heart transplantation, where we have observed patients who were receiving amiodarone at the time of transplant develop an acute ARDS syndrome, probably due to the combination of amiodarone and cyclosporine, and the other circumstances that obtain during cardiac transplantation.…”