Intertemporal Decision Making After Brain Injury: Amount-Dependent Steeper Discounting after Frontal Cortex Damage

Białaszek, Wojciech; Swebodziński, Bartłomiej; Ostaszewski, Paweł

doi:10.1515/ppb-2017-0052

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Additionally, the initiation of substance use usually occurs during adolescence, which is a high-risk period for the development of SUD due to the immaturity of prefrontal cortical systems responsible for impulse control (Kozak et al, 2018). Neuroadaptations to frontal cortical regions that are activated by cue-induced cravings, including the orbitofrontal cortex and medial prefrontal cortex, leads to impairment in inhibitory control, such as a tendency to preferentially prefer smaller, immediate rewards over larger, delayed rewards in DRD tasks (Białaszek et al, 2017;Damasio et al, 1996). Connectivity between the lateral prefrontal cortex and striatum has also been shown to be associated with lower temporal discounting (van den Bos et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Association between impulsivity and neural activation to alcohol cues in heavy drinkers

Burnette

Grodin

Lim

et al. 2019

Psychiatry Research: Neuroimaging

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This study examines associations between two measures of impulsivity and brain response to alcohol taste cues. Impulsivity is both a risk factor for and a consequence of alcohol use and misuse. Frontostriatal circuits are linked to both impulsivity and addiction-related behaviors, including response to alcohol cues. Non-treatment-seeking heavy drinkers (n = 55) completed (i) an fMRI alcohol taste cue-reactivity paradigm; (ii) the monetary choice questionnaire (MCQ), a measure of choice impulsivity where participants choose between smaller, sooner rewards and larger, delayed rewards; (iii) and the UPPS-P Impulsive Behavior Scale, a self-report measure assessing five impulsivity factors. General linear models identified associations between neural alcohol taste cue-reactivity and impulsivity, adjusting for age, gender, and smoking status. Selfreported sensation seeking was positively associated with alcohol taste cue-elicited activation in frontostriatal regions, such that individuals who reported higher sensation seeking displayed greater neural response to alcohol taste cues. Conversely, delay discounting was negatively associated with activation in frontoparietal regions, such that individuals who reported greater discounting showed less cue-elicited activation. There were no significant associations between other self-reported impulsivity subscales and alcohol taste cue-reactivity. These results indicate that sensation seeking is associated with reward responsivity, while delay discounting is associated with recruitment of self-control circuitry.

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Section: Introductionmentioning

confidence: 99%

Association between impulsivity and neural activation to alcohol cues in heavy drinkers

Burnette

Grodin

Lim

et al. 2019

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

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The intracortical myelin content of impulsive choices: results from T1- and T2-weighted MRI myelin mapping

et al. 2023

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Delay discounting (DD) refers to a phenomenon that humans tend to choose small-sooner over large-later rewards during intertemporal choices. Steep discounting of delayed outcome is related to a variety of maladaptive behaviors and is considered as a transdiagnostic process across psychiatric disorders. Previous studies have investigated the association between brain structure (e.g. gray matter volume) and DD; however, it is unclear whether the intracortical myelin (ICM) influences DD. Here, based on a sample of 951 healthy young adults drawn from the Human Connectome Project, we examined the relationship between ICM, which was measured by the contrast of T1w and T2w images, and DD and further tested whether the identified associations were mediated by the regional homogeneity (ReHo) of brain spontaneous activity. Vertex-wise regression analyses revealed that steeper DD was significantly associated with lower ICM in the left temporoparietal junction (TPJ) and right middle-posterior cingulate cortex. Region-of-interest analysis revealed that the ReHo values in the left TPJ partially mediated the association of its myelin content with DD. Our findings provide the first evidence that cortical myelination is linked with individual differences in decision impulsivity and suggest that the myelin content affects cognitive performances partially through altered local brain synchrony.

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Intertemporal Decision Making After Brain Injury: Amount-Dependent Steeper Discounting after Frontal Cortex Damage

Cited by 2 publications

References 44 publications

Association between impulsivity and neural activation to alcohol cues in heavy drinkers

Association between impulsivity and neural activation to alcohol cues in heavy drinkers

The intracortical myelin content of impulsive choices: results from T1- and T2-weighted MRI myelin mapping

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