Background: The development of major bleeding after percutaneous coronary intervention (PCI) is associated with higher morbidity and mortality, and advanced age is one of its main predictors. This analysis aimed to evaluate the impact of the use of the transradial approach on the incidence of bleeding complications in elderly patients undergoing PCI. Methods: This was a consecutive and controlled registry of patients ≥ 60 years of age undergoing PCI by the transradial approach. Angiographic procedure success, technical failure, and the incidence of ischaemic adverse events and major bleeding were evaluated. Results: Between May of 2008 and December of 2010, 707 elderly patients underwent PCI; in 635 patients (89.8%), the transradial approach was used. The mean age was 69.9 ± 7.2 years, and 11.5% were > 80 years of age. 39.7% of the patients female, and 30.9% had diabetes mellitus. Acute ischaemic syndrome accounted for 72% of the clinical indications. The angiographic success rate was 96.8%, with a crossover rate of 2.8%. The in-hospital mortality rate was 2.4%: myocardial infarction occurred in 0.9%, stroke occurred in 0.3%, and stent thrombosis occurred in 0.9%. Hematomas were reported in 1.6% of the procedures, with a major bleeding rate of 0.8%. Conclusions: In elderly patients undergoing PCI, representative of contemporary practice and with high risk of bleeding, the use of the transradial approach, was associated with a low major bleeding rate.