Intervention of pumpkin seed oil on metabolic disease revealed by metabonomics and transcript profile

Zhao, Xiu-Ju; Chen, Yulian; Fu, Bing; Zhang, Wen; Liu, Zhiguo; Zhuo, Hexian

doi:10.1002/jsfa.7842

Cited by 10 publications

(4 citation statements)

References 40 publications

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“…Lemak nabati yang berasal dari tempe biji labu kuning dan kacang kedelai merupakan lemak tak jenuh yang baik untuk kesehatan. Menurut Morrison et al (2015) dan Zhao et al (2015) minyak biji labu kuning dapat memperbaiki dislipidemia dengan menurunkan kadar kolesterol LDL dan trigliserida, menipiskan aterosklerosis dan memberi efek antiinflamasi.…”

Section: Hasil Dan Pembahasan Kandungan Gizi Bubuk Fungsionalunclassified

KOMPONEN GIZI, AKTIVITAS ANTIOKSIDAN DAN KARAKTERISTIK SENSORI BUBUK FUNGSIONAL LABU KUNING (Cucurbita moschata) DAN TEMPE

Junita¹,

Setiawan²,

Anwar³

et al. 2017

jgizipangan

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The aim of this research was to determine the nutrient content, antioxidant activity and the sensory characteristics of functional powder from pumpkin (Cucurbita moschata) Keywords: antioxidant activity, functional powder, nutrient content, sensory ABSTRAKPenelitian bertujuan untuk mengetahui kandungan gizi, aktivitas antioksidan, dan karakteristik sensori formula bubuk fungsional berbahan labu kuning serta tempe. Formula yang digunakan terdiri atas 15% bubuk labu kuning, 35% bubuk biji labu, 50% bubuk tempe. Komponen gizi ditentukan berdasarkan dengan analisis proksimat dan spektrofotometri, aktivitas antioksidan metode DPPH (2,2-diphenyl-1-picrylhidrazyl), serta karakteristik sensori formula dianalisis dengan bantuan 39 panelis semi terlatih menggunakan tiga jenis media minuman yaitu air putih, jus jeruk dan susu. Hasil penelitian menunjukkan bahwa bubuk fungsional mengandung 6,84±0,09% kadar air, 3,18±0,02% kadar abu, 35,15±0,07% lemak, 30,15±0,35% protein, 20,85±0,35% karbohidrat, 3,86±0,02% serat kasar, 308,85±0,55 ppm betakaroten, 515,00 ppb kromium, dan 4,59% total gula. Aktivitas antioksidan bubuk sebesar 6765.88 ppm. Karakteristik sensori pada media jus jeruk lebih baik dari media lainnya. Bubuk fungsional ini dapat dimanfaatkan sebagai alternatif dalam manajemen diabetes, namun perlu peningkatan karakter sensori serta telaah interaksi gizi yang lebih mendalam. 1978-1059 EISSN 2407-0920 DOI: 10.25182/jgp.2017.12.2.109.116 Terakreditasi SK Menristek Dikti 12/M/Kp/II/2015 PENDAHULUANPangan fungsional adalah pangan olahan yang mengandung satu atau lebih komponen pangan yang berdasarkan kajian ilmiah mempunyai fungsi fisiologis tertentu diluar fungsi dasarnya, terbukti tidak membahayakan dan bermanfaat bagi kesehatan (BPOM RI 2016). Menurut Kazeem dan Davies (2016), pangan fungsional adalah makanan dan minuman yang mampu mencegah, melindungi dan atau mengobati suatu penyakit dan juga memiliki nilai gizi yang baik.Perkembangan intervensi gizi penyakit yang erat kaitannya dengan jenis makanan, perlu mengikuti perkembangan pangan. Saat ini muncul tren minuman bubuk (powder drink) yang terbuat dari berbagai buah, sayur, dan biji yang mengandung senyawa antioksidan dan protein whey (Suratno et al. 2014).

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Section: Hasil Dan Pembahasan Kandungan Gizi Bubuk Fungsionalunclassified

KOMPONEN GIZI, AKTIVITAS ANTIOKSIDAN DAN KARAKTERISTIK SENSORI BUBUK FUNGSIONAL LABU KUNING (Cucurbita moschata) DAN TEMPE

Junita¹,

Setiawan²,

Anwar³

et al. 2017

jgizipangan

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“…Due to the rich content of omega-3 fatty acids in fish oil, it is increasingly used to treat cardiovascular diseases [ 3 ]; fish phospholipids have received extensive clinical attention because of their pharmacological activity affecting various diseases and are increasingly used for the prevention and treatment of chronic inflammation, cardiovascular disease, and cancer in humans. A diet with pumpkin seed oil can modulate a number of pathways that reduce the fat load on the liver to alleviate MetS [ 4 , 5 ]. This means that there may be certain substances in the oil that can affect metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics

Chen

Yi³

et al. 2022

Cells

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The number of metabolic syndromes (MetS) is increasing, and a fish phospholipid diet can reduce the risk of MetS. In this study, the changes in lipid metabolism of colon contents were analyzed by extensive lipidomics in mice with metabolic syndrome by fish phospholipid diet, and mice were randomly divided into experimental groups with different diet types by establishing a MetS model. After 14 weeks, the mice were sacrificed and the serum and colon contents were collected. Ultra-high liquid phase tandem mass spectrometry was used for broadly targeted lipidomic analysis, and the qualitative and quantitative detection of lipid metabolism changes in the colonic contents of mice. Under the intervention of fish phospholipids, MetS mice were significantly inhibited, serum total cholesterol (TC) and triglycerides (TG) decreased, serum high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels were improved, fasting blood glucose and insulin levels decreased, and inflammatory factors decreased. Through screening, it was found that thirty-three lipid metabolites may be key metabolites and five have significantly changed metabolic pathways. Modularizing lipid metabolites, it is possible to understand the extent to which different types and concentrations of fish phospholipids affect metabolic syndrome. Therefore, our study may provide new therapeutic clues for improving MetS.

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“…Pumpkin fruit is very rich in antioxidants. Pumpkin fruit is very rich in antioxidant beta carotene which is equal to 1.12 ± 0.03 mg/100gr [10]. β-carotene will be processed by the body into vitamin A.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Pumpkin Masker Usage on the Moisture of the Face Skin

Ayuningtyas¹,

Sista²,

Okatini³

2019

KSS

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Intervention of pumpkin seed oil on metabolic disease revealed by metabonomics and transcript profile

Abstract: These findings provide useful information to understand the metabolic alterations triggered by MD and to evaluate the effects of PSO intervention. © 2016 Society of Chemical Industry.

Cited by 10 publications

References 40 publications

KOMPONEN GIZI, AKTIVITAS ANTIOKSIDAN DAN KARAKTERISTIK SENSORI BUBUK FUNGSIONAL LABU KUNING (Cucurbita moschata) DAN TEMPE

KOMPONEN GIZI, AKTIVITAS ANTIOKSIDAN DAN KARAKTERISTIK SENSORI BUBUK FUNGSIONAL LABU KUNING (Cucurbita moschata) DAN TEMPE

Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics

The Influence of Pumpkin Masker Usage on the Moisture of the Face Skin

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