Interventional Effect of Nanosilver Paint on Fungal Load of Indoor Air in a Hospital Ward

Abstract

Hospital ward environments contain various types of microorganisms, in which fungal agents are one of the main contaminants that may cause hospital-acquired infections. Regarding this, the aim of the present study was to evaluate the effect of nanosilver paint on reducing fungal contaminants of indoor air in an educational, research, and treatment center. Two rooms in the hematology ward were selected. One room was painted using usual paint (control room) and the other room was painted with paint containing nanosilver particles (experimental room). One hundred and twelve samples were collected using active (Anderson BioSampler) and passive (settle plate or open plate) air sampling techniques. The samples were incubated for 3–7 days at 35°C, and the positive fungal cultures were examined according to morphological and microscopic characteristics. Following active sampling, the mean and standard deviation of the number of colony-forming units (CFU/m3) of fungi colonies in the experimental and control rooms were 29.21 ± 17.99 and 22.50 ± 10.02 before intervention and 13.79 ± 6.20 and 31.07 ± 21.1 after intervention, respectively. Following passive sampling, the number of CFU/plate in the experimental and control rooms was 6 and 0 before and 1and 1 after intervention, respectively. The use of the nanosilver paint was effective in reducing air fungal contamination. Moreover, the active sampling method was more sensitive to measuring the concentration changes for fungal bioaerosols.

The Immunoglobulin A and Interleukin-6 Levels of “Biosmart and Safe Bus” and Regular Bus Passengers

“…Nano silver is considered to be the most commonly used engineered nanomaterial and has many benefits such as antimicrobial properties, water and air filtering, as a biosensor and in vivo biomarker in diagnostics. [23] In a study by Rostami, et al in 2021, it was proven that the effectiveness of paint combined with silver nanoparticles in reducing the level of fungal contamination in hospital wards proved to be effective compared to paint without nanoparticle combinations. [24] In another study also explained that very small nano silver particles (dp < 10 nm) easily release ions from the oxidized surface which dominate the antibacterial performance.…”

“…[23] In a study by Rostami, et al in 2021, it was proven that the effectiveness of paint combined with silver nanoparticles in reducing the level of fungal contamination in hospital wards proved to be effective compared to paint without nanoparticle combinations. [24] In another study also explained that very small nano silver particles (dp < 10 nm) easily release ions from the oxidized surface which dominate the antibacterial performance. So that the effect of applying nano silver to the entire cabin of the Biosmart and safe bus buses can inhibit the increase in IL-6 compared to regular buses without the application of nanoparticles [23].…”

Green synthesis of selenium nanoparticles and evaluate their effect on the expression of ERG3, ERG11 and FKS1 antifungal resistance genes in Candida albicans and Candida glabrata

“…This enzyme is not present in mammals, and mutations in the coding region β-1,3-glucan synthase in the FKS1 and FKS2 genes are associated with decreased inhibitory efficacy of echinocandin antifungals (Dudiuk et al 2017). One way to overcome drug resistance is discovering new putative antifungal targets requiring sophisticated screening technologies (Vandeputte et al 2012;Rostami et al 2021). However, the development of biosynthesized nanoparticles (NPs) and their use in targeted drug delivery systems as a therapeutic agent can significantly reduce this problem (Pereira et al 2014;Mallmann et al 2015;Osanloo et al 2018;Sousa et al 2020).…”

“…2012; Rostami et al . 2021). However, the development of biosynthesized nanoparticles (NPs) and their use in targeted drug delivery systems as a therapeutic agent can significantly reduce this problem (Pereira et al .…”

Alteration of Cell Membrane Permeability by Cetyltrimethylammonium Chloride Induces Cell Death in Clinically Important Candida Species

“…On the other hand, a precise diagnosis of Candida infection and the administration of antifungal medications are not always possible in the group of patients with high mortality [3]. Therefore, ensuring adequate disinfectant/antiseptic procedures as a prophylactic step to decontaminate the hospital environment, including medical devices, is highly recommended, as it will in turn eventually prevent the persistent colonization of Candida species [4].…”