Interventional Neurophysiological Mapping during Spinal Cord Procedures

Deletis, Vedran; Camargo, Adauri Bueno de

doi:10.1159/000064585

Cited by 53 publications

(37 citation statements)

References 3 publications

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“…135 This can result in an unintentional myelotomy through the dorsal column and subsequent sensory defects, including proprioception loss with secondary gait instability. 28,35,52,56,79,93,114 As the thermal energy emitted from bipolar electrocautery may cause damage to adjacent spinal tracts, the utilization of sharp dissection in the plane of spinal fibers is the preferred method around these vital areas during tumor resection. Furthermore, debulking the center of the tumor early may aid in establishing the tumor/spinal cord plane prior to dorsal column retraction.…”

mentioning

confidence: 99%

Complications associated with the treatment for spinal ependymomas

Nagasawa

Smith

Cremer

et al. 2011

FOC

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Spinal cord ependymomas are rare neoplasms, comprising approximately 5% of all CNS tumors and 15% of all spinal cord tumors. Although surgery was once reserved for diagnosis alone, the evolution of surgical practices has elevated resection to the treatment of choice for these lesions. While technological advances continue to improve the capacity for gross-total resections and thus decrease the risk of recurrence, ependymoma spinal surgery still contains a variety of potential complications. The presence of neurological deficits and deterioration are not uncommonly associated with spinal cord ependymoma surgery, including sensory loss, dorsal column dysfunction, dysesthetic syndrome, and bowel and bladder dysfunction, particularly in the immediate postoperative period. Surgical treatment may also lead to wound complications and CSF leaks, with increased risk when radiotherapy has been involved. Radiation therapy may also predispose patients to radiation myelopathy and ultimately result in neurological damage. Additionally, resections of spinal ependymomas have been associated with postoperative spinal instability and deformities, particularly in the pediatric population. Despite the advances in microsurgical techniques and intraoperative cord monitoring modalities, there remain a number of serious complications related to the treatment of spinal ependymoma tumors. Identification and acknowledgment of these potential problems may assist in their prevention, early detection, and increased quality of life for patients afflicted with this disease.

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confidence: 99%

Complications associated with the treatment for spinal ependymomas

Nagasawa

Smith

Cremer

et al. 2011

FOC

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“…A recently developed technique, the D-wave collision technique, has allowed localization of the CST within the spinal cord (Deletis and Camargo, 2001 …”

Section: Intramedullary Corticospinal Tract Mappingmentioning

confidence: 99%

Electrophysiology and intraoperative neurophysiological monitoring

Novak

Oberndorfer

2012

Handbook of Clinical Neurology

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“…Clinically, functional electrical stimulation (FES) implants are being used more and more to treat intractable pain 72–76 and are also gaining momentum for the treatment of other disorders, such as urinary incontinence and Parkinsonian related disorders, 77–82 in most cases involving neurosurgical intervention. In addition, both stimulating and recording CNS electrodes are important neurophysiological and neuropathological experimental tools 73,77,80,81 , 83–93 . One of the most significant problems associated with the development of recording or stimulating chronic CNS electrodes is device failure associated with the fibrotic response mediated by glial and immune cells 77,78,94–96 .…”

Section: Platform Technologiesmentioning

confidence: 99%

“…In addition, both stimulating and recording CNS electrodes are important neurophysiological and neuropathological experimental tools. 73,77,80,81,[83][84][85][86][87][88][89][90][91][92][93] One of the most significant problems associated with the development of recording or stimulating chronic CNS electrodes is device failure associated with the fibrotic response mediated by glial and immune cells. 77,78,[94][95][96] To address this, some groups are focusing on the development of novel carbon nanofiber based electrode arrays for CNS neuronal stimulation and recording.…”

Section: Platform Technologiesmentioning

confidence: 99%

Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system

Silva

2010

Annals of the New York Academy of Sciences

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Nanotechnology is the science and engineering concerned with the design, synthesis, and characterization of materials and devices that have a functional organization in at least one dimension on the nanometer (i.e., one billionth of a meter) scale. The potential impact of bottom up self-assembling nanotechnology, custom made molecules that self-assemble or self-organize into higher ordered structures in response to a defined chemical or physical cue, and top down lithographic type technologies where detail is engineered at smaller scales starting from bulk materials, stems from the fact that these nanoengineered materials and devices exhibit emergent mesocale and macroscale chemical and physical properties that are often different than their constituent nanoscale building block molecules or materials. As such, applications of nanotechnology to medicine and biology allow the interaction and integration of cells and tissues with nanoengineered substrates at a molecular (i.e., subcellular) level with a very high degree of functional specificity and control. This review considers applications of nanotechnology aimed at the neuroprotection and functional regeneration of the central nervous system (CNS) following traumatic or degenerative insults, and nanotechnology approaches for delivering drugs and other small molecules across the blood-brain barrier. It also discusses developing platform technologies that may prove to have broad applications to medicine and physiology, including some being developed for rescuing or replacing anatomical and/or functional CNS structures.

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Interventional Neurophysiological Mapping during Spinal Cord Procedures

Cited by 53 publications

References 3 publications

Complications associated with the treatment for spinal ependymomas

Complications associated with the treatment for spinal ependymomas

Electrophysiology and intraoperative neurophysiological monitoring

Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system

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