Interventional Pulmonology: Determining an Ideal Technique, Phenotype-driven Management, and Finding Safer Alternatives

Ahmad, Kareem; Gabe, Luke; Cristan, Elaine; Factor, Phillip

doi:10.1164/rccm.201701-0246rr

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…41 Low-dose computed tomography (LDCT) is effective for the early detection of lung cancer in high-risk populations; it identifies early-stage lung cancers with high sensitivity and reduces lung cancer mortality. 42,43 Cancerspecific biomarkers, such as DNA, RNA, or proteins, exist in a bodily fluid, and these can be valuable in the early diagnosis and treatment of cancer. 44 Modern improved diagnosis technology helped more patients with early-stage NSCLC have the option of surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Wedge Resection and Lobectomy/Segmentectomy for Early-Stage Non-small Cell Lung Cancer: A Bayesian Meta-analysis and Systematic Review

Shi

et al. 2021

Ann Surg Oncol

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Background. Surgery has become an accepted method for the treatment of early-stage non-small cell lung cancer (NSCLC). The purpose of this Bayesian meta-analysis was to compare the overall survival (OS), disease-free survival (DFS), and relapse-free survival (RFS) between wedge resection and lobectomy/segmentectomy for treatment of early-stage NSCLC. Methods. Eligible studies were retrieved from Web of Science, PubMed, MEDLINE, Cochrane Library, EMBASE, CNKI, and WanFang up to July 2021 and screened based on established selection criteria. The Bayesian meta-analysis was performed with the combination of the reported survival outcomes of the individual studies using a random-effect model. The OS, DFS, and RFS of the wedge resection group was compared with the lobectomy/segmentectomy group. The hazard ratio (HR) and standard error were extracted or calculated for each study using the Kaplan-Meier method.Results. This study was registered with PROSPERO (INPLASY202080090).The pooled OS hazard ratio between segmentectomy and lobectomy was 1.1 [95% confidence interval (CI) 0.92-1.4], the pooled HR between lobectomy and wedge resection was 0.71 [95% CI 0.52-0.96], and the pooled HR between segmentectomy and wedge was 0.80 [95% CI 0.56-1.10]. The pooled HR of DFS or RFS was not statistically significant among the three surgical approaches. Conclusions. Patients with early-stage NSCLC received lobectomy had the lowest hazard ratio of OS than patients received wedge resection, indicating that the overall survival of patients received lobectomy was higher than patients received wedge resection. However, regarding DFS and RFS, the three surgical approaches showed no significant difference.

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Section: Discussionmentioning

confidence: 99%

Comparison Between Wedge Resection and Lobectomy/Segmentectomy for Early-Stage Non-small Cell Lung Cancer: A Bayesian Meta-analysis and Systematic Review

Shi

et al. 2021

Ann Surg Oncol

View full text Add to dashboard Cite

show abstract

Interventional Pulmonology: Determining an Ideal Technique, Phenotype-driven Management, and Finding Safer Alternatives

Cited by 1 publication

References 7 publications

Comparison Between Wedge Resection and Lobectomy/Segmentectomy for Early-Stage Non-small Cell Lung Cancer: A Bayesian Meta-analysis and Systematic Review

Comparison Between Wedge Resection and Lobectomy/Segmentectomy for Early-Stage Non-small Cell Lung Cancer: A Bayesian Meta-analysis and Systematic Review

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