Interventions for photodamaged skin

Melamed, Samuel; Brooke, Rebecca; Hollis, Sally; Griffiths, C.E.M.

doi:10.1002/14651858.cd001782.pub3

Cited by 13 publications

(17 citation statements)

References 64 publications

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“…As mentioned above, some substances have been proven to repair and prevent wrinkles. Many controlled studies have demonstrated that topical applications of retinoids reduce the severity of wrinkles [12]. All-transretinoic acid, a first-generation retinoid, induces production of procollagen types I and III through induction of TGF-β, a key player in fibroblast collagen synthesis [11].…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Succinylated Atelocollagen and Adenosine for the Treatment of Periorbital Wrinkles

Ryu¹,

Jung²,

Chung³

et al. 2013

JCDSA

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The degradation of structural collagen contributes to the characteristic appearance of wrinkles. The anti-wrinkle effects of a variety of substances have been studied, but the potential anti-wrinkle effects of topical applications of collagen for periorbital wrinkles have not been investigated. To evaluate the effects of topical application of succinylated atelocollagen on periorbital wrinkles and to compare the results of treatment with adenosine, a clinical study on Korean participants was carried out. Each participant's right or left periorbital area was treated with either a solution containing succinylated atelocollagen and adenosine or a solution containing only succinylated atelocollagen for two months. A placebo solution was applied to the opposite periorbital area of each patient's face for two months. Based on objective and subjective measurements of clinical improvement, the assessment scores for treated sites were statistically significantly higher than scores for placebo sites after two months of treatment. Analysis of silicone casts of periorbital wrinkles demonstrated partial effects of succinylated atelocollagen on periorbital wrinkles. However, we did not observe any effects of adenosine on periorbital wrinkles. Succinylated atelocollagen may be an effective treatment option for periorbital wrinkles, but further studies including a longer treatment period and larger subject group are needed to verify these results.

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Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Succinylated Atelocollagen and Adenosine for the Treatment of Periorbital Wrinkles

Ryu¹,

Jung²,

Chung³

et al. 2013

JCDSA

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“…Topical retinoids may cause an irritant reaction such as erythema, scaling, burning sensation, and dermatitis, and these reactions cause to decrease patient compliance. Therefore, retinoids should be initiated at the lowest effective dose to minimize adverse reactions [66]. Although tazarotene is the only topical retinoid with a category X designation, topical retinoids are not recommended during pregnancy or lactation [67].…”

Section: Topical Retinoidsmentioning

confidence: 99%

Molecular Mechanisms of Skin Aging and Rejuvenation

Kim¹,

Park²

2016

Molecular Mechanisms of the Aging Process and Rejuvenation

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The aging process in the skin is complex and influenced by more intrinsic and extrinsic factors than any other body organ. The effects of these two types of factors overlap for the most part. The combined effects of these two aging processes also affect dermal matrix alterations. The main clinical signs of skin aging include wrinkling and irregular pigmentation, which are influenced by a combination of intrinsic and extrinsic (e.g., UV radiation, heat, smoking, and pollutants) factors. Histologically, collagen decreases, and the dermis is replaced by abnormal elastic fibers as a cause of wrinkle formation through the loss of skin elasticity. There have been numerous studies of skin aging performed to elucidate the underlying molecular mechanisms and to develop various antiaging therapeutics and preventive strategies. We summarized the molecular mechanisms and treatments of skin aging. Mainly UV radiation induces ROS formation and DNA damage, leading to increased production of MMPs and decreased production of collagen in keratinocytes and fibroblasts, which reflect the central aspects of skin aging. Besides UV radiation exposure, extrinsic factors including tobacco smoking, exposure to environmental pollutants, infrared radiation, and heat contribute to premature skin aging. Like UV radiation, these factors cause ROS formation and increase expression of MMPs, thus accelerating skin aging by inducing extracellular matrix (ECM) degradation. Accumulated collagen fibrils inhibit the new collagen synthesis and account for the further degradation of the ECM through this positive feedback loop. Accumulating evidence for molecular mechanisms of skin aging should provide clinicians with an expanding spectrum of therapeutic targets in the treatment of skin aging.

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“…Since the introduction of retinoids for anti‐ageing strategies, various additional approaches have emerged to manage cutaneous signs of ageing, e.g. cosmeceuticals and vitamins . Minimally invasive surgery is also increasing, including the injection of neurotoxins, fillers or resurfacing procedures…”

Section: Definition Of Measurement Properties and Quality Criteriamentioning

confidence: 99%

Evaluation of skin ageing: a systematic review of clinical scales

et al. 2015

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Clinical scales are widely used in anti-ageing research and practice. More than 100 skin ageing scales exist, which makes it difficult to choose outcome measures and to compare study results. The objectives were to assess and evaluate the quality of measurement properties of available clinical skin ageing scales. A systematic review was conducted. Electronic databases including Medline (1970 to June 2013) and EMBASE (1974 to June 2013) were searched via Ovid SP. To enhance the sensitivity forward searches were conducted in Scopus and Web of Science. We identified 111 scales in 52 included publications. Thirty studies had good methodology for at least one measurement property. Forty-two scales were evaluated for their test-retest or interrater reliability. Nineteen showed high reliability coefficients. A further 15 instruments were partly supported by content and/or structural and/or criterion validity and/or hypotheses-testing evidence. The majority of existing clinical skin ageing scales were developed for evaluating facial characteristics. Many scales quantify similar constructs. In contrast to the high number of available scales there is limited evidence supporting their measurement properties. Recommendations for the use of specific skin ageing scales for clinical studies must be made with caution because of the high number of studies with poor methodology. Development of new instruments should be justified, and existing ones investigated for scale behaviour using appropriate methods. Future research should aim to select and/or adapt existing scales to identify the 'best' to improve clinical research and practice.

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Interventions for photodamaged skin

Cited by 13 publications

References 64 publications

The Efficacy and Safety of Succinylated Atelocollagen and Adenosine for the Treatment of Periorbital Wrinkles

The Efficacy and Safety of Succinylated Atelocollagen and Adenosine for the Treatment of Periorbital Wrinkles

Molecular Mechanisms of Skin Aging and Rejuvenation

Evaluation of skin ageing: a systematic review of clinical scales

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