Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats

Adelakun, Sunday Aderemi; Ukwenya, Victor Okoliko; Akingbade, Grace T.; Omotoso, O; Aniah, Julius Akomaye

doi:10.1016/j.bj.2019.07.004

Cited by 28 publications

(9 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Negative effects of mercury on reproductive traits in male rats include impairment of spermatogenesis, decrease in spermatozoa motility, and increase in pathological changes [ 171 , 172 , 173 , 174 , 175 , 176 , 177 ].…”

Section: Mercury (Hg)mentioning

confidence: 99%

“…Testicular toxicity of mercury chloride (HgCl 2 ) in adult male Wistar rats was reported [ 174 ]. In the mercury-exposed group (40 mg/kg bw; HgCl 2 ; orally daily; 28 days), histological profiles of the testes showed a derangement of the cytoarchitecture and deterioration of spermatozoa quality.…”

Section: Mercury (Hg)mentioning

confidence: 99%

“…In the mercury-exposed group, degeneration of the spermatogenic cells of the germinal epithelium, occlusion of the lumen of seminiferous tubules, hypertrophy of seminiferous tubules, and irregular vacuolized basement membrane were found. After 28 days of administration, a significant decrease in mean spermatozoa motility and spermatozoa count was detected in the mercury-exposed group [ 174 ]. Similar changes in testes were also confirmed after peroral mercury administration.…”

Section: Mercury (Hg)mentioning

confidence: 99%

See 2 more Smart Citations

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs

Massányi

Madeddu

et al. 2020

Toxics

146

View full text Add to dashboard Cite

Reproductive organs are essential not only for the life of an individual but also for the survival and development of the species. The response of reproductive organs to toxic substances differs from that of other target organs, and they may serve as an ideal “barometer” for the deleterious effects of environmental pollution on animal and human health. The incidence of infertility, cancers, and associated maladies has increased in the last fifty years or more, while various anthropogenic activities have released into the environment numerous toxic substances, including cadmium, lead, and mercury. Data from epidemiological studies suggested that environmental exposure to cadmium, lead, and mercury may have produced reproductive and developmental toxicity. The present review focused on experimental studies using rats, mice, avian, and rabbits to demonstrate unambiguously effects of cadmium, lead, or mercury on the structure and function of reproductive organs. In addition, relevant human studies are discussed. The experimental studies reviewed have indicated that the testis and ovary are particularly sensitive to cadmium, lead, and mercury because these organs are distinguished by an intense cellular activity, where vital processes of spermatogenesis, oogenesis, and folliculogenesis occur. In ovaries, manifestation of toxicity induced by cadmium, lead, or mercury included decreased follicular growth, occurrence of follicular atresia, degeneration of the corpus luteum, and alterations in cycle. In testes, toxic effects following exposure to cadmium, lead, or mercury included alterations of seminiferous tubules, testicular stroma, and decrease of spermatozoa count, motility and viability, and aberrant spermatozoa morphology.

show abstract

Section: Mercury (Hg)mentioning

confidence: 99%

Section: Mercury (Hg)mentioning

confidence: 99%

Section: Mercury (Hg)mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs

Massányi

Madeddu

et al. 2020

Toxics

146

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that 40 mg/kg of HgCl 2 -treatment decreased sperm motility, while the 40 mg/kg of HgCl 2 and 500 mg/kg of Solanum melongena (SM) treatments were able to increase sperm motility again. Through an antioxidant system of actions, SM improves spermatogenesis and reduces HgCl 2 -induced testicular toxicity [51]. Short-term exposure to HgCl 2 , even at 0.031 g/mL, was found to have adverse effects on sperm functions, generate spontaneous acrosome response, and inhibit capacitation via blocking tyrosine-containing protein phosphorylation.…”

Section: Discussionmentioning

confidence: 99%

Etlingera hemisphaerica Blume attenuates male reproductive toxicity due to mercury chloride in Mus musculus

Ruyani

Muthmainnah

Simatupang

et al. 2022

Preprint

View full text Add to dashboard Cite

This study evaluated the effects of leaf ethanolic extract Etlingera hemisphaerica Blume (LE3H) on male reproductive toxicity due to mercury chloride (HgCl2) in Mus musculus (mice). Those were three test materials; 5 mg/kg body weight (bw) HgCl2, 0.2 mg/gbw Immunos®, and 0.13, 0.26, 0.39 mg/gbw LE3H. On day 1 (d-1), four groups of 5 mice were given HgCl2 by gavage, and then on d-3, d-5, and d-7 days, three groups were administered 0.13, 0.26, and 0.39 mg/gbw of LE3H, another group as control. On d-16, the animals were killed using the cervical dislocation method for observing their testicular morphometrics. Three groups of 9 mice were given HgCl2 by injected on d-1, and then on d-4 one group was administered Immunos® and one group was administered a determined LE3H, another group as control, and then were killed on d-7 for measuring glucose and malondialdehyde (MDA). Two groups of 15 mice were injected with HgCl2 on d-1, and then on d-3, one group was administrated by the determined LE3H, another group as control, and then were killed on d-6 for investigating sperms quality. Results revealed that HgCl2 increased the weight, length, and diameter of the testes compared to the control, while HgCl2 + LE3H three times tended to restore testes similar to the control. A dose of LE3H (0.39 mg/gbw) was effective in testicular recovery conditions. HgCl2 increased blood glucose dan MDA levels compared to the control. The blood glucose dan MDA level on HgCl2 + Immunos® and HgCl2 + LE3H did not differ from the control. HgCl2 decreased sperm concentration compared to the control. HgCl2 + LE3H was lower than HgCl2 and approach the control. Sperm moves fast and straight in the control, HgCl2, and HgCl2 + LE3H were 30.63; 16.12; and 27.62% respectively. Thus, LE3H attenuates male reproductive toxicity duo to HgCl2 in mice.

show abstract

“…The whole was freeze-dried and a total dry mass of 53.53 g of the aqueous extract was obtained. This extract was kept at 4 °C in an airtight container until use [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

et al. 2022

Self Cite

View full text Add to dashboard Cite

Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats

Cited by 28 publications

References 39 publications

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs

Etlingera hemisphaerica Blume attenuates male reproductive toxicity due to mercury chloride in Mus musculus

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

Contact Info

Product

Resources

About