Interventions on Gut Microbiota for Healthy Aging

Zeppa, Sabrina Donati; Agostini, Deborah; Ferrini, Fabio; Gervasi, Marco; Barbieri, Elena; Bartolacci, Alessia; Piccoli, Giovanni; Saltarelli, Roberta; Sestili, Piero; Stocchi, Vilberto

doi:10.3390/cells12010034

Cited by 45 publications

(31 citation statements)

References 181 publications

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“…From our findings, it is evident that dosage size and administration days have a considerable impact on the diversity and relative abundance of gut microbiota. The gut microbiome acts as a modulator of host immune function, whose diversity and richness are affected by changeable factors, such as aging and sex, and constant factors, such as diet, medicinal therapies, and lifestyle [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Toxicity and Impact of Silica Nanoparticles on the Configuration of Gut Microbiota in Immunodeficient Mice

Shabbir

et al. 2023

Microorganisms

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Nanoparticles (NPs), having exceptional physicochemical and electrical characteristics with lower toxicity, have evolved as dynamic drug delivery carriers in living organisms. Potentially, the intragastric gavage of silica nanoparticles (SiNPs) affects gut microbiota profiles in immunodeficient mice. In this study, the impact of SiNPs of variable size and dosage was investigated in cyclophosphamide (Cy)-induced immunodeficient mice, specifically on their immune functions and gut microbiota, through physicochemical and metagenomic analysis. SiNPs of different sizes and doses were gavaged to Cy-induced immunodeficient mice for 12 days at an interval of 24 h to investigate their effects on immunological functions and the gut microbiome of mice. Our results showed that SiNPs had no significant toxicological effects on the cellular and hematological activities of immunodeficient mice. Furthermore, after the administration of different levels of SiNPs, no immune dysfunction was found in the immunosuppressed mice groups. However, gut-microbial studies and comparisons of characteristic bacterial diversity and compositions demonstrated that SiNPs significantly affect the abundance of different bacterial communities. LEfSe analysis revealed that SiNPs significantly increased the abundance of Lactobacillus, Sphingomonas, Sutterella, Akkermansia, and Prevotella, and potentially reduced Ruminococcus and Allobaculum. Thus, SiNPs significantly regulate and modify the configuration of the gut microbiota in immunodeficient mice. These dynamic variations in the intestinal bacterial community, abundance, and diversity provide new insight into the regulation and administration of silica-based NPs. This would be helpful for the further demonstration of the mechanism of action and prediction of the potential effects of SiNPs.

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Section: Discussionmentioning

confidence: 99%

Toxicity and Impact of Silica Nanoparticles on the Configuration of Gut Microbiota in Immunodeficient Mice

Shabbir

et al. 2023

Microorganisms

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“…They also contribute to the reduction of colonic inflammation and oxidative stress [ 32 , 33 ]. Furthermore, the composition and diversity of the gut microbiota are subject to various influences, including age, sex, diet, antibiotic use, stress, intestinal function, immune responses, genetic mutations, environmental factors, and diseases [ 28 ]. These factors collectively shape the intricate balance of the gut microbiota and its impact on host health.…”

Section: Literature Searchmentioning

confidence: 99%

“…Alterations in the microbial composition could lead to a reduction in diversity, which, in turn, may promote the growth of pathogenic bacteria [27]. Te gut microbiota maintains host health by regulating nutrient absorption and reinforcement of gut integrity and inhibiting the proliferation of pathogens, while also infuencing oxidative stress, metabolism, cognition, and the immune system [28][29][30].…”

Section: Gut Microbiota and Healthmentioning

confidence: 99%

Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications

Agbalalah,

Bur,

Nwonu

et al. 2024

Anemia

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Aim. Sickle cell disease has witnessed a 41.4% surge from 2000 to 2021, significantly affecting morbidity and mortality rates, particularly in children from regions with elevated under-5 mortality rates. Gut microbiota dysbiosis is increasingly recognised in SCD, exacerbating complications, particularly chronic pain, marked by significant alterations of proinflammatory bacteria abundance. This review explores the therapeutic potential of Akkermansia muciniphila and Roseburia spp. in alleviating SCD-related complications, emphasising their roles in maintaining gut barrier integrity, reducing inflammation, and modulating immune responses. Method. A literature search up to November 2023 using PubMed, MEDLINE, and Google Scholar databases explored SCD pathophysiology, gut microbiota composition, Akkermansia muciniphila and Roseburia spp. abundance, pain and gut dysbiosis in SCD, and butyrate therapy. Result. A. muciniphila and Roseburia spp. supplementation shows promise in alleviating chronic pain by addressing gut dysbiosis, offering new avenues for sustainable SCD management. This approach holds the potential for reducing reliance on reactive treatments and improving overall quality of life. This research underscores the pivotal role of the gut microbiome in SCD, advocating for personalised treatment approaches. Conclusion. Further exploration and clinical trials are needed to harness the full potential of these gut bacteria for individuals affected by this challenging condition.

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“…Dynamic Nature of the Gut Microbiota: The dynamic nature of the microbiota is well-established in early life, exhibiting minor fluctuations in diversity until middle age, followed by a period of relative stability [29][30][31].…”

Section: Age-related Shifts In Gut Microbiota Influenced Bymentioning

confidence: 99%

Exploring the functional roles of sustainable dietary patterns on gut microbiota composition and optimal health

Apalowo,

Adegoye,

Obuotor

2024

BCHD

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The aging population presents a growing global challenge, due to increased risk of age-related diseases, leading to arising burden on healthcare systems and highlighting the need for effective interventions to promote healthy aging. Emerging evidence suggests that certain dietary patterns can influence the gut microbiome favorably, potentially mitigating age-related chronic diseases and metabolic dysfunction such as diabetes, obesity, and cardiovascular diseases. Gut microbiota dynamics, initially stable in early life, are disrupted with age, impacting both prokaryotic and eukaryotic symbionts, resulting in an adaptive response in the gut microbiota defined by an increase in composition and diversity over time. In addition to environmental and genetic factors, the impact of diet has been noted as a critical factor that influences these dynamics. In this review, we propose sustainable dietary patterns like the Mediterranean, vegetarian, ketogenic, and DASH diets as a suitable panacea to counteract deleterious feeding patterns by offering nutritious and environmentally sustainable options, potentially lowering the prevalence of chronic diseases and further explores their functional roles with respect to modulating the gut microbiota composition, and their overall impact on optimal health. Keywords: Aging; healthy diet; Gut microbiota; Mediterranean Diet; Plant-based diet; dietary intervention

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Interventions on Gut Microbiota for Healthy Aging

Cited by 45 publications

References 181 publications

Toxicity and Impact of Silica Nanoparticles on the Configuration of Gut Microbiota in Immunodeficient Mice

Toxicity and Impact of Silica Nanoparticles on the Configuration of Gut Microbiota in Immunodeficient Mice

Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications

Exploring the functional roles of sustainable dietary patterns on gut microbiota composition and optimal health

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