Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery

Jeffers, Lisa; Reid, Joanne; Fitzsimons, Donna; Morrison, Patrick J.; Dempster, Martin

doi:10.1002/14651858.cd012894.pub2

Cited by 17 publications

(15 citation statements)

References 112 publications

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“…Studies have revealed that mindfulness-based interventions have a positive impact on symptom burden and psychological outcomes in patients with cancer (Rouleau et al, 2015 ). Specifically speaking, when patients suffer from destructive effects resulting from both external and internal stressors, the MBSR program initiates psychological adjustment to trigger positive psychological sources (positive reappraisal) (Jeffers et al, 2019 ), which may greatly dilute the destructive effects of stressors (Galante et al, 2021 ) and then restore patient's psychosomatic balance. As a result, patients' health outcomes would be significantly improved.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Mindfulness-Based Stress Reduction (MBSR) on Psychological Outcomes and Quality of Life in Patients With Lung Cancer: A Meta-Analysis

Tian

Liang

et al. 2022

Front. Psychol.

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ObjectiveThe impact of the mindfulness-based stress reduction (MBSR) program on psychological outcomes and quality of life (QoL) in lung cancer patients remains unclear. This meta-analysis aimed to evaluate the effectiveness of the MBSR program on psychological states and QoL in lung cancer patients.MethodsEligible studies published before November 2021 were systematically searched from PubMed, EMBASE, Cochrane Library, PsycINFO, China National Knowledge Infrastructure (CNKI), and Wanfang databases. The risk of bias in eligible studies was assessed using the Cochrane tool. Psychological variables and QoL were evaluated as outcomes. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to grade the levels of evidence. Statistical analysis was conducted using RevMan 5.4 and STATA 14.0.ResultsA total of 17 studies involving 1,680 patients were included for meta-analysis eventually. MBSR program significantly relieved cancer-related fatigue (standard mean difference [SMD], −1.26; 95% confidence interval [CI], −1.69 to −0.82; moderate evidence) and negative psychological states (SMD, −1.35; 95% CI, −1.69 to −1.02; low evidence), enhanced positive psychological states (SMD, 0.91; 95% CI, 0.56–1.27; moderate evidence), and improved quality of sleep (MD, −2.79; 95% CI, −3.03 to −2.56; high evidence). Evidence on MBSR programs' overall treatment effect for QoL revealed a trend toward statistical significance (p = 0.06, low evidence).ConclusionBased on our findings, the MBSR program shows positive effects on psychological states in lung cancer patients. This approach should be recommended as a part of the rehabilitation program for lung cancer patients.Systematic Review Registrationhttps://archive.org/details/osf-registrations-mwvbq-v1, identifier: 10.17605/OSF.IO/MWVBQ.

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Section: Discussionmentioning

confidence: 99%

The Impact of Mindfulness-Based Stress Reduction (MBSR) on Psychological Outcomes and Quality of Life in Patients With Lung Cancer: A Meta-Analysis

Tian

Liang

et al. 2022

Front. Psychol.

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“…Multimodal screening with Transvaginal Ultrasound (TVUS) and CA-125 versus TVUS alone or without screening, showed that multimodal screening is effective in detecting early-stage cancer; after a median of 11 years of follow-up, with no reduction in mortality; screening for familial ovarian cancer; women with an estimated lifetime risk of ovarian cancer not less than 10% were screened for ovarian cancer by CA-125 testing every 4 months; the Ovarian Cancer Risk Algorithm (ROCA) used to interpret the results and TVUS (annually or within 2 months if the ROCA score is abnormal) [25]; the sensitivity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) for screening for ovarian cancer at 1 year were 94.7, 10.8, and 100%, respectively. For women screened at risk of familial / genetic ovarian cancer, ROCA every 3 months had better early stage sensitivity with high specificity and a low but possibly acceptable PPV compared to CA125> 35 U / ml every 6 / every 12 months, warranting a larger cohort assessment [64].…”

Section: Risk Managementmentioning

confidence: 98%

Genetics of Breast and Ovary Cancers Associated with Hereditary Cancers and their Clinical Management

Hernández¹,

Vvh²

2021

COO

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1.1. Background: Carriers of the BRCA-1/2 mutation have increased and variable risks of Breast Cancer (BC) and ovarian cancer and vary or are modified by common genetic variants and their incidence genetic testing and risk-reducing surgery has increased, they should receive advice and evaluation by the physician with experience in genetics 1.2. Objective: The genetics of BRCA-1/2 gene mutations and their impact on women have been reviewed. Methods:We reviewed the publications in PubMed, Web of Science, Scopus, related to mutations of the BRCA-1/2 genes and hereditary cancers, to assess prevention, detection and management and how to improve quality of life 1.3. Results: increased use was identified of tests, as well as risk-reducing surgery, the use of new screening strategies; Still, there is no effective detection protocol that has been shown to reduce mortality, only risk-reducing surgery, such as mastectomy and bilateral salpingo-oophorectomy; recommended after parity satisfied, has improved chemoprevention and reproductive capacity. Conclusions:Identification of women who carry a pathogenic mutation in high-risk BRCA-1/2 genes; the clinical management, prevention and identification of related cancers improves the morbidity and mortality of these patients of their individual risk clinicsofoncology.com

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“…[4][5][6] Prophylactic surgery has been shown to be clinically effective and cost-effective for many high-risk groups, but come with mental, emotional, and physical health risks. [7][8][9][10][11][12] Prior studies have consistently identified underuse of and delayed prophylactic surgery utilization as impediments to genomic medicine's population impact on cancer outcomes. [13][14][15] Underuse of BSO and total hysterectomy are of specific concern because effective ovarian and endometrial cancer surveillance methods do not exist and these cancers are often diagnosed at a stage where treatment options are limited.…”

Section: Introductionmentioning

confidence: 99%

“…Except for chemoprevention and colonoscopy, these prophylactic surgeries are the only risk‐management approaches that reduce personal cancer risk 4–6 . Prophylactic surgery has been shown to be clinically effective and cost‐effective for many high‐risk groups, but come with mental, emotional, and physical health risks 7–12 . Prior studies have consistently identified underuse of and delayed prophylactic surgery utilization as impediments to genomic medicine's population impact on cancer outcomes 13–15 .…”

Section: Introductionmentioning

confidence: 99%

Risk‐reducing surgery in unaffected individuals receiving cancer genetic testing in an integrated health care system

Knerr

Guo

Mittendorf

et al. 2022

Cancer

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BACKGROUND: Germline genetic testing enables primary cancer prevention, including through prophylactic surgery. We examined riskreducing surgeries in unaffected individuals tested for hereditary cancer susceptibly between 2010 and 2018 in the Kaiser Permanente Northwest health system. METHODS: We used an internal genetic testing database to create a cohort of individuals who received tests including one or more high-penetrance hereditary cancer susceptibility gene. We then identified, after testing, bilateral mastectomy, bilateral salpingo-oophorectomy (BSO), and total hysterectomy procedures in electronic health record and claims data through 2019. We describe surgery utilization by genetic test results and National Comprehensive Cancer Network (NCCN) guidelines. RESULTS: The cohort included 1020 individuals, 16% with pathogenic/likely pathogenic (P/LP

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Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery

Abstract: Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery.

Cited by 17 publications

References 112 publications

The Impact of Mindfulness-Based Stress Reduction (MBSR) on Psychological Outcomes and Quality of Life in Patients With Lung Cancer: A Meta-Analysis

The Impact of Mindfulness-Based Stress Reduction (MBSR) on Psychological Outcomes and Quality of Life in Patients With Lung Cancer: A Meta-Analysis

Genetics of Breast and Ovary Cancers Associated with Hereditary Cancers and their Clinical Management

Risk‐reducing surgery in unaffected individuals receiving cancer genetic testing in an integrated health care system

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