Intestinal alkaline phosphatase in the diagnosis of liver disease.

Abstract

SUMMARY Alkaline phosphatase isoenzymes have been studied by acrylamide gel disc electrophoresis in 76 patients with liver disorders comprising 15 with an extrahepatic lesion, 53 with an intrahepatic lesion, and eight patients who had features of both intra-and extrahepatic disease. No intestinal band was found in the 15 cases of extrahepatic liver disease, in marked contrast to the patients with intrahepatic lesions in whom an intestinal band was found in 45% of cases. The intrahepatic group was heterogeneous, a high incidence of intestinal bands being found in patients with cirrhosis of the liver. It is concluded that where a raised serum alkaline phosphatase is found in a patient with jaundice, and a gut band is present on electrophoresis, the lesion is likely to be intrahepatic.

Pharmaceutical efficacy of harmalol in inhibiting hepatocellular carcinoma

“…The mechanism by which alkaline phosphatase reaches the circulation due to the leakage from the bile canaliculi into hepatic sinusoids may result from leaky tight junctions [55]. Elevated serum levels of intestinal alkaline phosphatase have been found in patients with cirrhosis [56]. Thus, ALP has been noted to be an HCC prognostic factor in general.…”

Liver function tests and their interpretation

“…5 Elevated serum levels of intestinal alkaline phosphatase have been found in patients with cirrhosis, particularly those with blood group type O, and may be associated specifically with intrahepatic disease as opposed to extrahepatic obstruction. 21 Hepatic and bony metastasis can also cause elevated levels of alkaline phosphatase. Other diseases like infiltrative liver diseases, abscesses, granulomatous liver disease and amyloidosis may also cause a rise in alkaline phosphatase.…”

Characterization of Equine Alkaline Phosphate Isoenzymes by Chemical Inhibition and Agaros Gel Electrophoresis

“…In man, however, serum-ALP of intestinal origin is reported in cases of malabsorption and steathorrhoe (YONG, 1966) and also in connection with the absorption of fatty acids from the intestines (WARNES et al, 1976;LINSCHER et al, 1971). A genetic disposition for the appearence of small intestinal ALP isoenzymes in blood serum of 0 and B blood groups has also been reported in man (WARNES et al, 1976(WARNES et al, ,1977SUNDBLAD et al, 1973;BAYER et al, 1980). N o such relations between certain breeds of horses or withinday variation for the detection of intestinal ALP has so far been detected in these investigations.…”