Intestinal and Extraintestinal Isospora belli Infection in an Aids Patient

Michiels, Jean‐François; Hofman, Paul; Bernard, E.; Paul, M.C. Saint; Boissy, C.; Mondain, V.; Lefichoux, Y.; Loubière, R

doi:10.1016/s0344-0338(11)80908-8

Cited by 58 publications

(37 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Isospora belli) is a coccidial parasite of humans that can cause serious disease in immunocompromised hosts. Extraintestinal stages of C. belli have been observed in several patients with immunodeficiencies (Restrepo et al, 1987;Comin and Santucci, 1994;Michiels et al, 1994;Velá squez et al, 2001). In these patients, numerous monozoic cysts are present in extraintestinal tissue samples or in the lamina propria of the small intestine.…”

Section: Discussionmentioning

confidence: 99%

Development and Ultrastructure of Cystoisospora canis Nemeséri, 1959 (syn. Isospora canis) Monozoic Cysts in Two Noncanine Cell Lines

Mitchell

Zajac

Lindsay

2009

Journal of Parasitology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Development and Ultrastructure of Cystoisospora canis Nemeséri, 1959 (syn. Isospora canis) Monozoic Cysts in Two Noncanine Cell Lines

Mitchell

Zajac

Lindsay

2009

Journal of Parasitology

View full text Add to dashboard Cite

“…37 Isosporiasis can also show extraintestinal dissemination features, affecting the mesenteric, periaortic, mediastinal and tracheobronchial lymph nodes. 38,39 It may also be related to biliary disease, causing manifestations of acalculous cholecystitis. 37 Isospora belli differs morphologically from Cryptosporidium sp not only because of its intrinsic morphology (elliptical oocyst measuring 22 x 15 µm in diameter, containing two sporocysts with four sporozooites), but also for the intracellular location in the absorptive cell, while Cryptosporidium is restricted to the brush borders, immediately under the apical membrane of absorptive cells.…”

Section: Isosporiasismentioning

confidence: 99%

“…38,39 It may also be related to biliary disease, causing manifestations of acalculous cholecystitis.…”

mentioning

confidence: 99%

Enteric parasites and AIDS

Cimerman

Lewi

1999

Sao Paulo Med. J.

View full text Add to dashboard Cite

Amongst the causes of diarrhea in developing countries, those of a parasitic origin are prominent in patients with AIDS.Opportunistic infections caused by intestinal parasites also vary according to the geographical area and the endemic levels in each location.The progressive decline of immunological and mucous defense mechanisms predisposes patients to early, intermediary and late gastrointestinal manifestations of HIV infection. 6 At later stages of the disease, the alterations in non-specific defense mechanisms in the production of Ig A and the reduction in local immune cell response also progress, thus increasing the susceptibility to a number of intestinal opportunistic pathogens, among which Cryptosporidium parvum, Isospora belli and Microsporidia species are the most prominent. 7After the emergence of AIDS, these parasites, until then known solely in veterinary medicine, were no longer considered as commensal organisms and are nowadays recognized as opportunistic pathogens common to these patients. Infections by these agents constitute a major secondary aggravating factor of the disease, often responsible for worsening the general health conditions, due to manifestations of diarrhea which are difficult to control, sometimes resulting in the death of the patient. CRYPTOSPORIDIASISCryptosporidiasis, a disease caused by an intracellular protozoan named Cryptosporidium sp, was described for the first time in 1907 by Tyzzer. This parasite was considered a commensal up to 1975, when it was identified as the cause of diarrhea in animals. 8 The first manifestation of cryptosporidiasis was reported by Nine et al. in 1976, and the disease became a major concern when the notification of the first 21 patients was given, 14 of whom died of chronic diarrhea caused by Cryptosporidium sp infection. 9 It is worth noting that outbreaks of epidemic linked to contaminated water are of extreme importance for the dissemination of this parasite such as the 1993 Milwaukee (USA) cryptosporidiasis outbreak, in which 403,000 human cases were reported, thereby becoming a relevant public health concern.10-12 After this outbreak, it was recommended that immunocompromised patients should be extremely careful with water, foodstuffs and contact with animals.Cryptosporidiasis is distributed over all continents. In Haiti and the African continent the prevalence is 50%, 13 while in the USA it ranges from 3 to 4%.14 In Brazil, due to the continental size of the country, the rates of incidence vary with the location. In the city of São Paulo, for instance, reports have referred to levels around 12.1 to 24.44%. [15][16][17] However, the latest epidemiological report on Brazil, dated February 1998, shows a cryptosporidiasis rate of only 3.5%. 18Cryptosporidiasis in AIDS patients usually causes chronic, bulky and intermittent diarrhea, with liquid non-bloody stools, accompanied by pain and abdominal colic, and a noticeable loss of weight can be observed. 8Asymptomatic cases are rarely described, occurring mostly in developing countries with pati...

show abstract

“…Although coccidiosis may also affect other organs outside the intestine such as the spleen, liver, and lymph nodes, 6 this is the first time that it has been reported in the endometrium. The pathogenesis of the endometritis in our patient remains obscure because she had not had diarrhoea and had no signs of immunodeficiency.…”

Section: Discussionmentioning

confidence: 79%

Endometrial coccidiosis

Otazu

2004

J Clin Pathol

View full text Add to dashboard Cite

This report describes a case of granulomatous endometritis caused by coccidiosis in an immunologically uncompromised 63 year old patient. The glandular epithelium of the endometrium contained numerous intracytoplasmic cysts, corresponding to periodic acid Schiff positive and methenamine silver negative sporoblasts. The endometrial glands revealed reactive phenomena, such as eosinophilic and squamous glandular metaplasia and intraluminal desquamation. Non-necrotising epithelioid granulomata, lacking the presence of parasites, were present in the stroma. Although not detected in the stool examination, the organisms were probablyIsospora belli. There was no evidence of other foci of the disease. Coccidiosis should be differentiated from the more commonly occurring coccidiomycosis.

show abstract

Intestinal and Extraintestinal Isospora belli Infection in an Aids Patient

Cited by 58 publications

References 9 publications

Development and Ultrastructure of Cystoisospora canis Nemeséri, 1959 (syn. Isospora canis) Monozoic Cysts in Two Noncanine Cell Lines

Development and Ultrastructure of Cystoisospora canis Nemeséri, 1959 (syn. Isospora canis) Monozoic Cysts in Two Noncanine Cell Lines

Enteric parasites and AIDS

Endometrial coccidiosis

Contact Info

Product

Resources

About