Intestinal and Systemic Immune Development and Response to Vaccination Are Unaffected by Dietary (1,3/1,6)-β-
            <scp>d</scp>
            -Glucan Supplementation in Neonatal Piglets

Hester, Shelly N.; Comstock, Sarah S.; Thorum, Shannon C.; Monaco, Marcia H.; Pence, Brandt D.; Woods, Jeffrey A.; Donovan, Sharon M.

doi:10.1128/cvi.00338-12

Cited by 18 publications

(18 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, low MW β-glucan increased ADG of piglets before LPS challenging, meanwhile, under immunochallenged status, β-glucan administration improved piglet growth regardless of MW when compared to the LPS group. The results are different from previous studies, which indicated that β-glucan had no effects on non-immunochallenged piglets [24]. A potential explanation for this discrepancy involves the differences of glucan source, optimal concentration, and its purity in the diet formulation in various studies.…”

Section: Discussioncontrasting

confidence: 90%

Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Luo

Chen

Mao

et al. 2019

Animals

View full text Add to dashboard Cite

Simple SummaryBeta-glucan is currently under consideration as an alternative to in-feed antibiotics for the sustainable pig production industry in China. Modulating intestinal function by β-glucan treatment in young pigs is one potential way of decreasing disease susceptibility and presumably increasing growth performance. In the present study, as a newly developed commercial product, β-glucans have proved to modulate gut function, and have improved growth performance in lipopolysaccharide (LPS)-challenged piglets. The present study aimed to determine the mechanisms involved inβ-glucan of low and high molecular weight mediated growth alterations in weaned piglets. The results confirmed that β-glucans isolated from Agrobacterium sp. ZX09 could improve growth performance in weaned piglets and they showed intestinal modulatory properties via different mechanisms in regulating the mucosal barrier function and microbial populations between two different molecular weight β-glucans.AbstractThis study investigated β-glucan derived from Agrobacterium sp. ZX09 with high (2000 kDa) and low (300 kDa) molecular weight (MW) to compare their effects on growth performance and gut function in LPS-induced weaned piglets. Changes in jejunal morphology, mucosal barrier function, microbial populations, and fermentation in the piglets were determined. Data showed that β-glucan prevented body weight loss in LPS challenged piglets. Supplementation with both β-glucan fractions improved jejunal morphology. Compared to low MW, β-glucan of high MW generally up-regulated transcripts of ZO-1, MUC1, and MUC2 in jejunal mucosa to a lesser extent. Mucosal D-lactate, diamine oxidase, and anti-oxidation index were effectively resumed in β-glucan treatment. Both β-glucan diets provoked the emergence of a balanced microbiota and a richer concentration of volatile fatty acids in the colon. The richest community of bifidobacterium and concentration of butyrate emerged after feeding β-glucan with high MW. Results suggested that the effect of Agrobacterium sp. ZX09 β-glucans on the gut-modulatory function is largely linked to their MW. Low MW β-glucan mainly improved the mucosal barrier function in the jejunum, while high MW β-glucan had profound effects on the microbial community and fermentation in the hindgut of piglets.

show abstract

Section: Discussioncontrasting

confidence: 90%

Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Luo

Chen

Mao

et al. 2019

Animals

View full text Add to dashboard Cite

show abstract

“…However, it should be noted that only a small number of animals were sampled and that the level of LPS induced IL-10 produced by MLN cells was relatively low (0–61 pg/mL). Nevertheless, these results are in line with other in vivo studies that showed limited or no effects of yeast-derived β-glucans on the (mucosal) immune system or vaccination response [ 58 , 65 , 66 , 67 ].…”

Section: Discussionsupporting

confidence: 89%

“…These results are in accordance with a previous study that investigated the effect of (purified) yeast-derived (1,3/1,6)-β-d-Glucan (Wellmune WGP ® ) on the vaccination response and T-cell subsets in neonatal piglets. The authors did not find any effect of this dietary supplement on intestinal or immune development and it did not improve the antibody response to vaccination in neonatal piglets [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life

et al. 2020

View full text Add to dashboard Cite

Piglets are susceptible to infections in early life and around weaning due to rapid environmental and dietary changes. A compelling target to improve pig health in early life is diet, as it constitutes a pivotal determinant of gut microbial colonization and maturation of the host’s immune system. In the present study, we investigated how supplementation of yeast-derived β-glucans affects the gut microbiota and immune function pre- and post-weaning, and how these complex systems develop over time. From day two after birth until two weeks after weaning, piglets received yeast-derived β-glucans or a control treatment orally and were subsequently vaccinated against Salmonella Typhimurium. Faeces, digesta, blood, and tissue samples were collected to study gut microbiota composition and immune function. Overall, yeast-derived β-glucans did not affect the vaccination response, and only modest effects on faecal microbiota composition and immune parameters were observed, primarily before weaning. This study demonstrates that the pre-weaning period offers a ‘window of opportunity’ to alter the gut microbiota and immune system through diet. However, the observed changes were modest, and any long-lasting effects of yeast-derived β-glucans remain to be elucidated.

show abstract

“…Many studies reported that beta‐glucan supplementation enhanced growth performance in pigs (Lee et al, ; Sweeney et al, ). But the current results are inconsistent with no effects on non‐immunochallenged piglets (Hester et al, ). An alternative explanation for this discrepancy involves in the differences of optimum concentration, purity, molecular weight, conformation, chemical modification and solubility of beta‐glucan in the diet formulation.…”

Section: Discussioncontrasting

confidence: 92%

Beta‐glucan from Agrobacterium sp. ZX09 improves growth performance and intestinal function in weaned piglets

Luo

Liu

et al. 2019

Animal Physiology Nutrition

View full text Add to dashboard Cite

Beta‐glucan is currently under consideration as an alternative to in‐feed antibiotics. The aim of the study was to investigate Agrobacterium sp. ZX09 beta‐glucan on intestinal morphology, cytokine concentration, mucin expression and microbial populations of weaning piglets. Pigs were randomly assigned to one of five dietary treatments supplemented with 0, 25, 50, 100 and 200 mg/kg beta‐glucan. Data showed an increase in ADG at the 100 mg/kg group (p = .03). A significant increase in villus height and reduction in crypt depth were fund in ileal tissue at the 100 mg/kg inclusion level (p < .05). Dietary supplementation of 100 mg/kg beta‐glucan enhanced IL‐10 concentration (p = .04) and gene expression of MUC1 and MUC2 (p < .05) in the jejunum. Dietary supplementation of 100 mg/kg beta‐glucan provoked the up‐regulation of Lactobacillus counts and down‐regulation of Escherichia coli counts in the caecum (p = .05). Data suggested that improved growth performance in response to beta‐glucan supplementation at 100 mg/kg in weaned piglets may be explained by the improved intestinal function.

show abstract

Intestinal and Systemic Immune Development and Response to Vaccination Are Unaffected by Dietary (1,3/1,6)-β- d -Glucan Supplementation in Neonatal Piglets

Cited by 18 publications

References 43 publications

Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life

Beta‐glucan from Agrobacterium sp. ZX09 improves growth performance and intestinal function in weaned piglets

Contact Info

Product

Resources

About