Intestinal barrier and gut microbiota: Shaping our immune responses throughout life

Takiishi, Tatiana; Fénero, Camila Idelí Morales; Câmara, Niels Olsen Saraiva

doi:10.1080/21688370.2017.1373208

Cited by 665 publications

(488 citation statements)

References 202 publications

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“…Intestinal symbiotic microbes could regulate the intestinal epithelial barrier function by their nature of resistance to pathogens (59). Our findings showed that the microbial diversity (a-and b-diversity) of the colonic and caecal mucosa did not change between NBW and LBW pigs, which was consistent with the previous results for analysis of their fecal microbiota during the neonatal stage (60).…”

Section: Discussionsupporting

confidence: 91%

Original low birth weight deteriorates the hindgut epithelial barrier function in pigs at the growing stage

Tao

Bai

et al. 2019

FASEB j.

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The deteriorative effect of low birth weight (LBW) on the mucosal permeability of the small intestine in piglets has been widely confirmed. However, whether the hindgut epithelial barrier function in LBW pigs is deteriorated during the growing stage is still unclear. Our study investigated differences in the hindgut epithelial barrier function between LBW and normal birth weight pigs during the growing stage (d 90). Our data demonstrated that the hindgut epithelium of LBW pigs has a high histopathological score, accompanied by decreased antioxidant capacity and increased apoptosis rate, as well as elevated expression and activity of caspase‐3. In addition, the number of intestinal goblet cells and gene expression of mucin 2 were significantly down‐regulated in LBW pigs. The expression of tight junction proteins (ZO‐1 and occludin) was markedly inhibited by the LBW. The mRNA abundance of inflammatory cytokines such as TNF‐α, IL‐1β, and IL‐8 was significantly increased in the hindgut mucosa of LBW pigs. Furthermore, our data revealed that LBW altered the intestinal microbial community in the hindgut mucosa of pigs. Collectively, these finding add to our understanding of the mechanisms responsible for hindgut epithelial barrier dysfunction in LBW pigs during the growing stage and facilitate the development of nutritional intervention strategies.—Tao, S., Bai, Y., Li, T., Li, N., Wang, J. Original low birth weight deteriorates the hindgut epithelial barrier function in pigs at the growing stage. FASEB J. 33, 9897–9912 (2019). http://www.fasebj.org

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Section: Discussionsupporting

confidence: 91%

Original low birth weight deteriorates the hindgut epithelial barrier function in pigs at the growing stage

Tao

Bai

et al. 2019

FASEB j.

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“…Lipopolysaccharide acts as an endotoxin, and microbiota containing lipopolysaccharide interfere with the function of the epithelial barrier, leading to chronic inflammation and CRC. However, the intestinal microbiota can regulate the renewal and reorganization of TJs of intestinal epithelial cells, thereby enhancing the barrier function . The mucus layer of the intestinal epithelium is a sterile environment containing some biomolecules, such as secretory immunoglobulin A (sIgA), antimicrobial peptides (AMPs), microbe‐associated molecular patterns (MAMPs), trefoil factor peptides (TFFs), resistin‐like molecules β (RELMβ), and Fc‐γ binding proteins .…”

Section: The Importance Of the Intestinal Epithelial Barrier And Micrmentioning

confidence: 99%

“…However, the intestinal microbiota can regulate the renewal and reorganization of TJs of intestinal epithelial cells, thereby enhancing the barrier function. 8 The mucus layer of the intestinal epithelium is a sterile environment containing some biomolecules, such as secretory immunoglobulin A (sIgA), antimicrobial peptides (AMPs), 9 microbe-associated molecular patterns (MAMPs), trefoil factor peptides (TFFs), resistin-like molecules β (RELMβ), and Fc-γ binding proteins. 10 A study using aseptic mice showed that the thickness of the mucus layer was reduced compared to the rodents with an intact microbiota.…”

Section: The Importance Of the Intestinal Epithelial Barrier And Micrmentioning

confidence: 99%

The role of microbiota in the development of colorectal cancer

Dai

Zhang

et al. 2019

Intl Journal of Cancer

104

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Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation.

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“…The role of the intestinal bacterial flora in intestinal immune response regulation and mucosal barrier function has attracted increasing interest . The gut microbiota of patients with CD are different from that of healthy controls .…”

Section: Introductionmentioning

confidence: 99%

“…The role of the intestinal bacterial flora in intestinal immune response regulation and mucosal barrier function has attracted increasing interest. 4,5 The gut microbiota of patients with CD are different from that of healthy controls. 6 Animal studies have demonstrated that the postnatal period is an important phase for enteric host-microbe homeostasis, and early life perturbations of the gut microbiota by infection or antibiotic use could potentially lead to adverse gastrointestinal tract outcomes in humans later in life.…”

Section: Introductionmentioning

confidence: 99%

Infection, antibiotic exposure, and risk of celiac disease: A systematic review and meta‐analysis

Jiang

Zhang

Zhou

et al. 2019

J of Gastro and Hepatol

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Background and Aim There is evidence of a relationship between infection (and the associated antibiotic exposure) and the risk of celiac disease (CD). This study performed a meta‐analysis to investigate this relationship. Methods To identify relevant studies, we conducted systematic searches of the PubMed, Embase, and Cochrane databases for articles published up to April 2019. Random effects models were used to determine overall pooled estimates and 95% confidence intervals (CIs). Results The meta‐analysis included 19 observational studies (15 on infection and six on antibiotic exposure). Our results showed that any infection was associated with an increased risk of CD later in life (odds ratio, 1.37; 95% CI: 1.2–1.56; P < 0.001). The I2 was 94% (high heterogeneity among studies). Subgroup analyses suggested that the risk of CD is not affected by the type of infectious agent, timing of exposure, and site of infection. Exposure to antibiotics was also associated with new‐onset CD (odds ratio, 1.2; 95% CI: 1.04–1.39; P < 0.001). Conclusion Exposure to early infection or antibiotic appears to increase the odds of developing CD, suggesting that intestinal immune or microbiota dysbiosis may play a role in the pathogenesis of CD. These findings may influence clinical management and primary prevention of CD. However, noncausal explanations for these positive associations cannot be excluded.

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Intestinal barrier and gut microbiota: Shaping our immune responses throughout life

Cited by 665 publications

References 202 publications

Original low birth weight deteriorates the hindgut epithelial barrier function in pigs at the growing stage

Original low birth weight deteriorates the hindgut epithelial barrier function in pigs at the growing stage

The role of microbiota in the development of colorectal cancer

Infection, antibiotic exposure, and risk of celiac disease: A systematic review and meta‐analysis

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