Intestinal Calcium-Binding Protein in the Developing Rat Duodenum

Gleason, Wallace A.; Lankford, Gary L.

doi:10.1203/00006450-198206000-00001

Cited by 11 publications

(2 citation statements)

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“…The expression of calbindin-Dsv in the enterocytes during early childhood probably reflects that an active vitamin D dependent calcium absorptive mechanism is operating. The trend in calbindin-D 9K during childhood is consistent with the results of experimental studies in the rat, showing that both calbindin-Dsy and active calcium absorption increase shortly after weaning in the rat to taper off when the rat matures (3,4,12). No measurements of plasma 1,25-dihydroxyvitamin D were performed in the present study, and we are hence unable to document to what extent individual differences in vitamin D status may have influenced calbindin-Dsy measurements.…”

Section: Discussionsupporting

confidence: 80%

Measurement of Calbindin‐D_9K in Small Intestinal Biopsy Specimens of Children

Staun,

Pærregaard,

Krasilnikoff

1991

J. pediatr. gastroenterol. nutr.

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SummaryThe vitamin D dependent intestinal calcium‐binding protein (calbindin‐D9K) was measured by an enzyme‐linked immunoadsorbent assay in small intestinal biopsy specimens from 10 children (aged 15–126 months). The aim was to study the relationship between calcium‐binding protein and age, bone age, and height. The patients were examined due to complaints of chronic diarrhea, but no evidence of malabsorption was found. The amount of calbindin‐D9K per mg of soluble protein in the small intestinal biopsy specimens was higher than previously studied in normal adults. Calbindin‐D9K correlated inversely with chronological age, bone age, and height of the children (p = −0.87, p = −0.66, and p = – 0.66; p < 0.05). A direct correlation was found between calbindin‐D9K and intestinal alkaline phosphatase activity (p = 0.60; p < 0.05). The decline in calbindin‐D9K may indicate that the active vitamin D dependent intestinal calcium absorption decreases during childhood.

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Section: Discussionsupporting

confidence: 80%

Measurement of Calbindin‐D_9K in Small Intestinal Biopsy Specimens of Children

Staun,

Pærregaard,

Krasilnikoff

1991

J. pediatr. gastroenterol. nutr.

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show abstract

“…Fourth, the change to a saturable calcium transport may be related to the maturation of an intestinal calcium binding protein paralleled by the maturation of cholecalciferol hydroxylases. Indeed, immunoreactive calcium binding protein and calcium activity are markedly enhanced during the weanling period in the rat (5). Calcium transport in the intestine during early development was found not to be mediated by vitamin D, but a vitamin D-sensitive transport system developed around the time of weaning (6).…”

Section: Discussionmentioning

confidence: 97%