Intestinal carriage of vancomycin-resistant enterococci in a community setting in Casablanca, Morocco

Hannaoui, Imane; Barguigua, Abouddihaj; Serray, Bahija; Mdaghri, N. El; Timinouni, Mohammed; Chaoui, A.; Azhari, M. El

doi:10.1016/j.jgar.2016.03.008

Cited by 13 publications

(11 citation statements)

References 17 publications

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“…They are responsible for serious infections, such as surgical infection,1 aortic valve endocarditis, meningitis and bacteremia. 2 While Enterococcus faecalis and Enterococcus faecium are most commonly recovered from humans, Enterococcus hirae is more frequently identified in animal infections. 3 Enterococcus durans is found in the intestines of animals and is responsible for very rare cases of endocarditis in humans.…”

Section: Introductionmentioning

confidence: 99%

Occurrence, molecular and antimicrobial resistance of Enterococcus spp. isolated from raw cow’s milk trade by street trading in Meknes city, Morocco

Bouymajane¹,

Filali²,

Oulghazi³

et al. 2018

Germs

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Section: Introductionmentioning

confidence: 99%

Occurrence, molecular and antimicrobial resistance of Enterococcus spp. isolated from raw cow’s milk trade by street trading in Meknes city, Morocco

Bouymajane¹,

Filali²,

Oulghazi³

et al. 2018

Germs

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“…The VRE colonization rate of healthy adults is inconsistent in the literature, ranging from 0 to 21% ( Balzereit-Scheuerlein and Stephan, 2001 ; Kolar et al, 2006 ; Hannaoui et al, 2016 ; Decker et al, 2018 ). Decker et al (2018) examined 800 health care personnel and found no VRE colonization.…”

Section: Discussionmentioning

confidence: 99%

Colonization With Multidrug-Resistant Organisms Among Healthy Adults in the Community Setting: Prevalence, Risk Factors, and Composition of Gut Microbiome

et al. 2020

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Background: The prevalence of colonization with multidrug-resistant organisms (MDROs) among healthy adults in the community is largely unknown. This study investigated the colonization rate of multidrug-resistant Enterobacteriaceae, methicillinresistant Staphylococcus aureus (MRSA), and vancomycin-resistant enterococci (VRE) in the community in Taiwan, and compared the gut microbiota between MDRO carriers and non-carriers.

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“…29 Over the last 6 years, the first reports of VRE in North Africa were published, including countries like Algeria, Tunisia, and Morocco. [11][12][13][14][15]30 Except for the study from Morocco, MLST and PCR-based determination of antibiotic resistance genes was performed to determine genetic relatedness of isolates. So far, there are no reports on VRE in Libya, except for one case where VRE was cultured from a war casualty with previous hospitalization history, but this strain was not MLST typed or further characterized.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of these VRE cases are represented by vanA-positive E. faecium of multilocus sequence type (MLST) ST18, ST80, and ST78 that belong to the global Clade A1. [11][12][13][14][15] In this study, we performed whole genome sequencing (WGS) to determine the genetic relatedness of the first 43 reported cases of VRE isolated from hospitalized patients throughout 2013-2014 at the Tripoli Medical Center. The Tripoli Medical Center is the largest national Libyan hospital by size and population, providing different medical and health care services to Tripoli as well as the north-west region of Libya.…”

Section: Introductionmentioning

confidence: 99%

Whole Genome Sequence Analysis of the First Vancomycin-Resistant Enterococcus faecium Isolates from a Libyan Hospital in Tripoli

Ahmed

Elramalli

Baptiste

et al. 2020

Microbial Drug Resistance

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The purpose of the study was to investigate the molecular characteristics and genetic relatedness of the first reported cases of vancomycin-resistant enterococci (VRE) from the Tripoli Medical Center, Libya. In total, 43 VRE isolates were obtained from various clinical sites throughout the years 2013-2014, including 40 vanA-type and 2 vanB-type vancomycin-resistant Enterococcus faecium isolates and 1 vanC1-type Enterococcus gallinarum. Of the 42 E. faecium, 19 isolates were subjected to whole genome sequencing. Core genome multilocus sequence typing (cgMLST) analysis revealed three sequence clusters (SCs) of clonally related isolates, which were linked to different hospital wards. The first two VRE isolates, isolated early 2013 from patients in the medical intensive care unit, were grouped in SC1 (MLST [ST] 78, vanB) and differed in only 3 of 1423 cgMLST alleles. The SC2 (n = 16, special care baby unit, neonatal intensive care unit, pediatric surgery ward, and oncology ward) and SC3 (n = 1, antenatal ward) were all ST80 vanA-VRE, but the single SC3 isolate differed in 233 alleles compared with SC2. Within SC2, isolates differed in 1-23 alleles. Comparison with a larger database of E. faecium strains indicated that all isolates clustered within the previously defined hospital clade A1. A combination of Resfinder and mlplasmid analysis identified the presence of resistance genes on different plasmid predicted genetic elements among different SCs. In conclusion, this study documents the first isolates causing outbreaks with VRE in the Libyan health care system. Further surveillance efforts using molecular typing methods to monitor spread of multidrug-resistant bacteria in the Libyan health care system are urgently needed.

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Intestinal carriage of vancomycin-resistant enterococci in a community setting in Casablanca, Morocco

Cited by 13 publications

References 17 publications

Occurrence, molecular and antimicrobial resistance of Enterococcus spp. isolated from raw cow’s milk trade by street trading in Meknes city, Morocco

Occurrence, molecular and antimicrobial resistance of Enterococcus spp. isolated from raw cow’s milk trade by street trading in Meknes city, Morocco

Colonization With Multidrug-Resistant Organisms Among Healthy Adults in the Community Setting: Prevalence, Risk Factors, and Composition of Gut Microbiome

Whole Genome Sequence Analysis of the First Vancomycin-Resistant Enterococcus faecium Isolates from a Libyan Hospital in Tripoli

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