Intestinal Cholecalciferol Absorption in the Elderly and in Younger Adults

Barragry, John; Corless, D.; Gupta, Sanjana; Switala, S.; Boucher, Barbara J; Cohen, R. D.

doi:10.1042/cs0550213

Cited by 72 publications

(62 citation statements)

References 17 publications

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“…The estimated half-life of 25OHD in infants is 2-3 wk (717), similar to values in adults (59,62,189,344,449), which means that a higher cord blood 25OHD will only influence neonatal levels over about the first 6 wk. Randomized intervention studies indicate that typical maternal vitamin D doses of 400-1,000 IU/day do not consistently increase breast milk content of vitamin D or 25OHD, whereas with maternal vitamin D doses of 2,000 -4,000 IU/day, an increase in milk content of vitamin D and 25OHD and neonatal 25OHD can be demonstrated (13,14,402,780).…”

Section: Human Datamentioning

confidence: 58%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

383

524

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During pregnancy and lactation, female physiology adapts to meet the added nutritional demands of fetuses and neonates. An average full-term fetus contains ϳ30 g calcium, 20 g phosphorus, and 0.8 g magnesium. About 80% of mineral is accreted during the third trimester; calcium transfers at 300-350 mg/day during the final 6 wk. The neonate requires 200 mg calcium daily from milk during the first 6 mo, and 120 mg calcium from milk during the second 6 mo (additional calcium comes from solid foods). Calcium transfers can be more than double and triple these values, respectively, in women who nurse twins and triplets. About 25% of dietary calcium is normally absorbed in healthy adults. Average maternal calcium intakes in American and Canadian women are insufficient to meet the fetal and neonatal calcium requirements if normal efficiency of intestinal calcium absorption is relied upon. However, several adaptations are invoked to meet the fetal and neonatal demands for mineral without requiring increased intakes by the mother. During pregnancy the efficiency of intestinal calcium absorption doubles, whereas during lactation the maternal skeleton is resorbed to provide calcium for milk. This review addresses our current knowledge regarding maternal adaptations in mineral and skeletal homeostasis that occur during pregnancy, lactation, and post-weaning recovery. Also considered are the impacts that these adaptations have on biochemical and hormonal parameters of mineral homeostasis, the consequences for long-term skeletal health, and the presentation and management of disorders of mineral and bone metabolism.

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Section: Human Datamentioning

confidence: 58%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

383

524

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“…of total 25-hydroxyvitamin D (25-OH D) (5 ) because the half-life of 25-OH D is ϳ3 weeks whereas the half-life of vitD is ϳ24 h (6,7 ). Dietary supplementation of food and vitamin tablets comes in the form of both vitD 2 and vitD 3 ; it is therefore essential that both analytes are measured equimolarly.…”

mentioning

confidence: 99%

Routine Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry Assay for Simultaneous Measurement of the 25-Hydroxy Metabolites of Vitamins D2 and D3

Maunsell¹,

Wright²,

Rainbow³

2005

Clinical Chemistry

351

267

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“…But a cross-sectional study conducted by Alhumaidia et al 21 found a contrasting result. Vitamin D status is known to be lower in the elderly compared with the young as the subcutaneous synthesis of vitamin D decreases with increasing age, due to a reduced concentration of 7-dehydrocholesterol in the skin 22 and reduced absorption of oral vitamin D. 23 Even though our study found a inverse association between duration and mean Vitamin D levels, the age difference between study groups must be taken into account.…”

Section: Resultsmentioning

confidence: 52%

Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients

Kishore¹,

Choudhary²,

Jain³

2017

Indian Journal of Medical Biochemistry

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Introduction: Vitamin D has a great impact on human health and disease. Recent studies proved that hypovitaminosis D is a possible risk factor for the pathogenesis of diabetes and its complications. In the present study, we evaluated vitamin D levels and its correlation with the duration of diabetes, sex, glycosylated hemoglobin (HbA1C), and microvascular complications in type II diabetes mellitus (T2DM) patients with and without microvascular complications. Objectives:To study and correlate vitamin D levels and its relation with duration of diabetes, sex, glycemic control, and microvascular complication in T2DM patients with and without microvascular complications. Materials and methods:Cross-sectional case-control study of 200 patients (35-70 years) suffering from T2DM was included. The T2DM patients without microvascular complications served as control group. Enrolled subjects underwent complete physical examination to detect the presence of microvascular complications, which includes microfilament tests, detailed fundus examination, urinary microalbumin/creatinine ratio. Fasting blood sugar, HbA1C, and serum vitamin D were also measured by using serum sample. Results:Prevalence of vitamin D deficiency and insufficiency was found to be significantly higher in T2DM patients with microvascular complications (19.54 ± 2.56 vs 28.57 ± 2.93) as compared with T2DM patients without microvascular complications (p < 0.001). Hypovitaminosis D was found to be significantly more in females (60.75%) compared with males (39.96%) in both the study groups (p < 0.0001). Hypovitaminosis D was correlated with glycemic control and prevalence of microvascular complications. Conclusion:Vitamin D is correlated with glycemic status and sex difference and has a role in pathogenesis of T2DM and its complications.

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Intestinal Cholecalciferol Absorption in the Elderly and in Younger Adults

Cited by 72 publications

References 17 publications

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Routine Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry Assay for Simultaneous Measurement of the 25-Hydroxy Metabolites of Vitamins D2 and D3

Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients

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