Intestinal Integrity and
            <i>Akkermansia muciniphila</i>
            , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Collado, María Carmen; Derrien, Muriel; Isolauri, Erika; Vos, Willem M. de; Salminen, Seppo

doi:10.1128/aem.01477-07

Cited by 591 publications

(504 citation statements)

References 18 publications

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“…In contrast, Akkermansia muciniphila tended to be associated with proinflammatory signals, namely, higher TNF-α and IFN-γ concentrations in colostrum and lower concentrations of IL10 and IL4 during lactation. Indeed, we were surprised to detect this mucin-degrading gut bacterium in breast milk, notwithstanding its previously reported presence among gut microbiota in infants (31). Given its capability to degrade intestinal mucus, Akkermansia muciniphila may indirectly affect the innate and adaptive immune responses (32).…”

Section: Maternal Bmi Impact On Milk Componentsmentioning

confidence: 98%

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

et al. 2012

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IntroductIon: Breast milk is an optimal source of nutrition for infants. It contains bioactive components including bacteria that support the microbial colonization and immune system development of the infant. The determinants of human milk composition remain poorly understood, although maternal nutritional and immunological status as well as lifestyle and dietary habits seem to have an impact. Methods: The subjects selected were women from a prospective follow-up study categorized by BMI. Milk samples were taken after delivery and at 1 and 6 mo later for analysis of composition in regard to transforming growth factor (TGF)-β2, soluble cD14 (scD14), cytokines, and microbiota. results: TGF-β2 and scD14 levels in the breast milk of overweight mothers tended to be lower than the levels in that of normal-weight mothers. also, higher levels of Staphylococcus group bacteria and lower levels of Bifidobacterium group bacteria were detected in overweight mothers as compared with normal-weight ones. The prevalence of Akkermansia muciniphila-type bacteria was also higher in overweight mothers, and the numbers of these bacteria were related to the interleukin (IL)-6 concentration in the colostrum, which was in turn related to lower counts of Bifidobacterium group bacteria in the breast milk of overweight women. dIscussIon: complex interactions of cytokines and microbiota in breast milk guide the microbiological, immunological, and metabolic programming of infant health. Our data may indicate the presence of an additional mechanism that may explain the heightened risk of obesity for infants of overweight and excessive weight gain mothers.

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Section: Maternal Bmi Impact On Milk Componentsmentioning

confidence: 98%

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

et al. 2012

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“…In addition, Akkermansia muciniphila, a gra��negative anaerobic bacte� ria belonging to the bacterial �hylu� Verruco�icrobia [82] , was strongly induced in animals fed alcohol for 3 wk. Akkermansia muciniphila is a co��on bacterial co��onent of the hu�an intestinal tract and has been found to degrade �ucin in �ure culture [83,84] . By degrading the intestinal �ucus as �art of the innate i��une syste�, bacterial translocation might be facilitated.…”

Section: Intestinal Microbiome Changes In Alcoholic Liver Diseasementioning

confidence: 99%

Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease

Yan¹

2012

WJH

101

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Alcoholic liver disease progresses through several stages of tissue damage, from simple steatosis to alcoholic hepatitis, fibrosis, or cirrhosis. Alcohol also affects the intestine, increases intestinal permeability and changes the bacterial microflora. Liver disease severity correlates with levels of systemic bacterial products in patients, and experimental alcoholic liver disease is dependent on gut derived bacterial products in mice. Supporting evidence for the importance of bacterial translocation comes from animal studies demonstrating that intestinal decontamination is associated with decreased liver fibrogenesis. In addition, mice with a gene mutation or deletion encoding receptors for either bacterial products or signaling molecules downstream from these receptors, are resistant to alcohol-induced liver disease. Despite this strong association, the exact molecular mechanism of bacterial translocation and of how changes in the intestinal microbiome contribute to liver disease progression remains largely unknown. In this review we will summarize evidence for bacterial translocation and enteric microbial changes in response to alcoholic liver injury and chronic alcoholic liver disease. We will further describe consequences of intestinal dysbiosis on host biology. We finally discuss how therapeutic interventions may modify the gastrointestinal microflora and prevent or reduce alcoholic liver disease progression

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“…Indeed, in the absence of dietary nutrients colonization of the intestinal microorganism Bacteroides thetaiotaomicron is reliant on host-derived glycans, which it metabolizes by means of polysaccharide utilization loci (4), showing that under such circumstances endogenous carbohydrates influence the composition of the intestinal microbiota (3). Recently, another constituent of human gut microbiota, Akkermansia muciniphila, was identified as an important mucin degrader (5,6), but little is known regarding the genetic elements required for this property.…”

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confidence: 99%

Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging

Turroni

Bottacini²,

Foroni³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

334

382

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The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.coevolution | genomics | host-glycans metabolism | human gut intestinal bacteria | mucin

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Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Cited by 591 publications

References 18 publications

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease

Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging

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