Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery

Banerjee, Amrita; Chen, Renwei; Arafin, Shamsul; Mitragotri, Samir

doi:10.1016/j.jconrel.2019.01.037

Cited by 51 publications

(28 citation statements)

References 56 publications

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“…The current applied to the cell was adjusted to 50 µA using a potentiometer. 18) The current was applied to the cell for one hour as pulsed current (10 min current on) followed by (10 min recovery/off period). 19) After one hour, the electrical current was switched off and then at predetermined time intervals 1 mL was removed from the receptor chamber and replaced with the same volume for 3 h. 18) The samples were centrifuged at 5000 rpm for 10 min and then the supernatant was analyzed for insulin content by ELISA.…”

Section: Methodsmentioning

confidence: 99%

In Vitro and in Vivo Comparative Study of Oral Nanoparticles and Gut Iontophoresis as Oral Delivery Systems for Insulin

ELKHATIB

Ali²,

Al-badrawy³

2021

Biological & Pharmaceutical Bulletin

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Multiple daily injections of insulin for diabetes cause many hazards for diabetic patients. Oral noninvasive insulin delivery could be more convenient and less painful than parenteral route. In past decades transdermal iontophoresis had been studied for insulin delivery across the skin with or without chemical permeation enhancers. However, the results of these studies were not efficacious and serum insulin levels were not therapeutically effective. In the present study an advanced technology "gut iontophoresis" for insulin delivery across the gut wall was compared with traditional oral insulin delivery in the form of nanoparticles. In vitro application of electric current to the intestinal membrane could enhance the flux of insulin nanoparticles (3.4 fold enhancement of insulin transport) from the donor to the receptor compartment in the Franz cell. In vivo iontophoresis of insulin nanoparticles through the gut wall would produce intense hypoglycemia (57% glycemia drop in 3 h) without damage of the intestinal tissues. Cell viability assay indicated that 50-500 µg/mL nanoparticles had no toxic effect on Caco-2 cells. Nanoparticles gut iontophoresis could be a promising non-invasive technique for oral insulin delivery.

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Section: Methodsmentioning

confidence: 99%

In Vitro and in Vivo Comparative Study of Oral Nanoparticles and Gut Iontophoresis as Oral Delivery Systems for Insulin

ELKHATIB

Ali²,

Al-badrawy³

2021

Biological & Pharmaceutical Bulletin

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“…Micropatches (also called wafers or films) can be designed as drug carriers with a typical size of 2-10 cm 2 and a thickness of 20-500 μm [ [147] , [148] , [149] ]. They can be classified as melt away, rapid disintegrating, and sustained-release, referring to their different drug release rates and disintegration times as detailed by Kirsch et al .…”

Section: Micro and Nanoscale Carrier Typesmentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

169

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Micro and nanocarriers Micro and nanoscale technologies Oral drug delivery Tissue models Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro-and nanoscale technologies, with an unprecedented ability to create, control, and measure micro-or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.

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“…Intestinal polymeric patch systems have been employed to deliver insulin either alone or in combination with iontophoresis [ 162 , 163 ]. In particular, patches have been delivered inside enteric-coated capsules, which adhered to the intestinal epithelium thanks to their mucoadhesive properties.…”

Section: Evolution Of Macromolecule Deliverymentioning

confidence: 99%

“…Permeation enhancers and peptidase inhibitors increased absorption and protected insulin from the harsh environment, respectively. A 3-fold increase in the insulin delivered across intestinal cells was noted for similarly prepared patches excluding the permeation enhancer when combined with an intermittent electric current [ 163 ]. Epitomee Medical’s shape-shifting device concept leverages the mucoadhesive properties of its external layer to attach to the intestinal wall and deliver the drug cargo ( Figure 2 I).…”

Section: Evolution Of Macromolecule Deliverymentioning

confidence: 99%

Future Perspectives of Oral Delivery of Next Generation Therapies for Treatment of Skin Diseases

et al. 2021

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Gene therapies have conspicuously bloomed in recent years as evidenced by the increasing number of cell-, gene-, and oligo-based approved therapies. These therapies hold great promise for dermatological disorders with high unmet need, for example, epidermolysis bullosa or pachyonychia congenita. Furthermore, the recent clinical success of clustered regularly interspaced short palindromic repeats (CRISPR) for genome editing in humans will undoubtedly contribute to defining a new wave of therapies. Like biologics, naked nucleic acids are denatured inside the gastrointestinal tract and need to be administered via injections. For a treatment to be effective, a sufficient amount of a given regimen needs to reach systemic circulation. Multiple companies are racing to develop novel oral drug delivery approaches to circumvent the proteolytic and acidic milieu of the gastrointestinal tract. In this review, we provide an overview of the evolution of the gene therapy landscape, with a deep focus on gene and oligonucleotide therapies in clinical trials aimed at treating skin diseases. We then examine the progress made in drug delivery, with particular attention on the peptide field and drug-device combinations that deliver macromolecules into the gastrointestinal tract. Such novel devices could potentially be applied to administer other therapeutics including genes and CRISPR-based systems.

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Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery

Cited by 51 publications

References 56 publications

<i>In Vitro</i> and <i>in Vivo</i> Comparative Study of Oral Nanoparticles and Gut Iontophoresis as Oral Delivery Systems for Insulin

<i>In Vitro</i> and <i>in Vivo</i> Comparative Study of Oral Nanoparticles and Gut Iontophoresis as Oral Delivery Systems for Insulin

Micro and nanoscale technologies in oral drug delivery

Future Perspectives of Oral Delivery of Next Generation Therapies for Treatment of Skin Diseases

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