Intestinal microbiota and the immune system in metabolic diseases

Sittipo, Panida; Lobionda, Stefani; Lee, Yun Kyung; Maynard, Craig L.

doi:10.1007/s12275-018-7548-y

Cited by 105 publications

(68 citation statements)

References 81 publications

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“…Intestinal microbiota is recently referred as a "hidden organ," including a wide range of bacteria, with an extension of a gene pool much more abundant than that from the host. Intestinal microbiota and perturbations in the composition of the microbiota support numerous nutritional, metabolic, immunological, and physiological processes [8][9][10][11]. Amit-Romach et al [12] found that VAD diets alter the composition of intestinal microflora by decreasing the relative proportion of lactobacillus spp.…”

Section: Introductionmentioning

confidence: 99%

Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency

Zhou

Tang

et al. 2020

Journal of Diabetes Research

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Aims. The underlying mechanisms involved in Vitamin A- (VA-) related changes in glucose metabolic disorders remain unclear. Recent evidence suggests that intestinal microbiota is closely linked to the metabolic syndrome. Here, we explored whether and how intestinal microbiota affects glucose homeostasis in VA-deficient diet-fed mice. Methods. Six-week-old male C57BL/6 mice were randomly placed on either a VA-sufficient (VAS) or VA-deficient (VAD) diet for 10 weeks. Subsequently, a subclass of the VAD diet-fed mice was switched to a VA-deficient rescued (VADR) diet for an additional 8 weeks. The glucose metabolic phenotypes of the mice were assessed using glucose tolerance tests and immunohistochemistry staining. Changes in intestinal microbiota were assessed using 16S gene sequencing. The intestinal morphology, intestinal permeability, and inflammatory response activation signaling pathway were assessed using histological staining, western blots, quantitative-PCR, and enzyme-linked immunosorbent assays. Results. VAD diet-fed mice displayed reduction of tissue VA levels, increased area under the curve (AUC) of glucose challenge, reduced glucose-stimulated insulin secretion, and loss of β cell mass. Redundancy analysis showed intestinal microbiota diversity was significantly associated with AUC of glucose challenge and β cell mass. VAD diet-driven changes in intestinal microbiota followed the inflammatory response with increased intestinal permeability and higher mRNA expression of intestinal inflammatory cytokines through nuclear factor-κB signaling pathway activation. Reintroduction of dietary VA to VAD diet-fed mice restored tissue VA levels, endocrine hormone profiles, and inflammatory response, which are similar to those observed following VAS-controlled changes in intestinal microbiota. Conclusions. We found intestinal microbiota effect islet function via controlling intestinal inflammatory phenotype in VAD diet-fed mice. Intestinal microbiota influences could be considered as an additional mechanism for the effect of endocrine function in a VAD diet-driven mouse model.

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Section: Introductionmentioning

confidence: 99%

Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency

Zhou

Tang

et al. 2020

Journal of Diabetes Research

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“…Our previous study indicated that DAP induced the metabolism of the colon microflora by increasing the production of six types of short‐chain fatty acids (Liu et al ., ), which results were in line with those from this study. An increasing number of studies have shown that the colon microbiota has great benefits in immune homeostasis and autoimmunity; and play an important role in the development of CD4 + cells both within and outside the intestine (Ekmekciu et al ., ; Sittipo et al ., ). The Erysipelotrichaceae genus, which appeared to be highly immunogenic and could potentially flourish post‐treatment with broad spectrum antibiotics, was significantly increased in abundance ( P value < 0.05), inferring with the potential of DAP to promote colon immunity via this specific pathway (Kaakoush, ).…”

Section: Resultsmentioning

confidence: 97%

Health‐promoting effects of dietary polysaccharide extracted from Dendrobium aphyllum on mice colon, including microbiota and immune modulation

Liu

Wang

2018

Int J of Food Sci Tech

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The health-promoting effects of a polysaccharide (DAP) purified from Dendrobium aphyllum, on mice colon were investigated. The results indicated that consumption of DAP facilitated the differentiation degree of CD4 + T cells to Th 1 , Th 17 and Treg cells; and depressed the differentiation degree to Th 2 cells, since DAP up-regulated IL-6 expression (from 1.08 AE 0.24 to 3.40 AE 0.36). Besides, oral administration of DAP reduced the gastrointestinal transit time from 255 AE 1.21 to 164 AE 0.46 min, decreased the pH from 6.70 AE 0.27 to 5.54 AE 0.31, improved faecal water-binding capability from 59.4% AE 0.35 to 63.5% AE 0.22. Additionally, the increase in four health-promoting short chain fatty acids were observed, which might result from the enrichment of the relative abundance of health-promoting microbiota genera, including Porphyromonadaceae and Ruminococcaceae. The DAP-induced up-regulation of the genus Erysipelotrichaceae might be related to the homeostasis in both Th 1 /Th 2 and Treg/Th 17 .

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“…Moreover, as this is not a placebo-controlled trial, the effects could be due to other environmental changes. Finally, there is also the possibility that albendazole affects macro- and microbiomes directly, which can affect the immune system [33-35]. …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Atopy following Mass Drug Administration with Albendazole: A Study in School Children on Flores Island, Indonesia

Staal

Hogendoorn

Voets

et al. 2018

Int Arch Allergy Immunol

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Background: In many rural areas of tropical countries such as Indonesia, the prevalence of soil-transmitted helminths (STH) infections remains high. At the same time, the burden of allergic disorders in such rural areas is reported to be low and inversely associated with helminth infections. To reduce the morbidity and transmission of helminth infections, the world health organization recommends preventive treatment of school children by providing mass drug administration (MDA) with albendazole. Here, we had an opportunity to evaluate the prevalence of skin reactivity to allergens before and after albendazole treatment to get an indication of the possible impact of MDA on allergic sensitization. Methods: A study was conducted among 150 school children living in an area endemic for STH infections. Before and 1 year after anthelminthic treatment with albendazole, stool samples were examined for the presence of STH eggs, skin prick tests (SPT) for cockroach and house dust mites were performed, blood eosinophilia was assessed, and total immunoglobulin E (IgE) and C-reactive protein (CRP) were measured in plasma. Results: Anthelminthic treatment significantly reduced the prevalence of STH from 19.6 before treatment to 6% after treatment (p < 0.001). Levels of total IgE (estimate: 0.30; 95% CI 0.22–0.42, p < 0.0001), CRP (estimate: 0.60; 95% CI 0.42–0.86, p = 0.006), and eosinophil counts (estimate: 0.70; 95% CI 0.61–0.80, p < 0.001) decreased significantly. The prevalence of SPT positivity increased from 18.7 to 32.7%. Multivariate analysis adjusted for confounding factors showed an increased risk of being SPT positive to any allergen (OR 3.04; 95% CI 1.338–6.919, p = 0.008). Conclusions: This study indicates that 1 year of MDA with albendazole was associated with a reduced prevalence of STH infections. This study shows that the prevalence of allergic sensitization increases after 1 year of albendazole treatment. Placebo-controlled and larger studies are needed to further substantiate a role of deworming treatment in an increased risk of allergic sensitization.

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Intestinal microbiota and the immune system in metabolic diseases

Cited by 105 publications

References 81 publications

Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency

Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency

Health‐promoting effects of dietary polysaccharide extracted from Dendrobium aphyllum on mice colon, including microbiota and immune modulation

Prevalence of Atopy following Mass Drug Administration with Albendazole: A Study in School Children on Flores Island, Indonesia

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