Intestinal permeability and its significance in psychiatric disorders – A narrative review and future perspectives

Wasiak, Jakub; Gawlik-Kotelnicka, Oliwia

doi:10.1016/j.bbr.2023.114459

Cited by 20 publications

(14 citation statements)

References 115 publications

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“…While a healthy person’s microbiome usually remains stable in a state of eubiosis, there is no doubt that food and lifestyle choices can affect the dynamics of gut microbial composition. Unhealthy habits can lead to dysbiosis, which is defined as a disturbance in the gut microbiota that disrupts intestinal homeostasis, induces inflammation, and negatively impacts intestinal permeability [ 31 ]. This relationship is demonstrated schematically in Figure 1 .…”

Section: Gut-brain Axismentioning

confidence: 99%

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Czarnik,

Fularski,

Gajewska

et al. 2024

Nutrients

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Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain–gut axis is an object that remains the target of modern research, and it is not without reason that many researchers enrich it with microbiota and diet in its name. Numerous connections and mutual correlations have become the basis for seeking answers to many questions related to pathology as well as human physiology. Disorders of this homeostasis as well as dysbiosis itself accompany neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Heavily dependent on external factors, modulation of the gut microbiome represents an opportunity to advance the treatment of neurodegenerative diseases. Probiotic interventions, synbiotic interventions, or fecal transplantation can undoubtedly support the biotherapeutic process. A special role is played by diet, which provides metabolites that directly affect the body and the microbiota. A holistic view of the human organism is therefore essential.

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Section: Gut-brain Axismentioning

confidence: 99%

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Czarnik,

Fularski,

Gajewska

et al. 2024

Nutrients

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“…Disruption of BBB and intestinal permeability (gut-blood barrier dysfunction) is a key contributor of multiple neurological diseases. ( 68 , 69 ) This may due to the passage of neurotoxic elements such as gut microbiota-derived products and ingested metals/chemicals to CNS where they cause pathological changes. SM enriched diet may prevent this by restoring/maintaining the integrity of BBB and GBB.…”

Section: Potential Therapeutic Effects Of Sm Supplementation In Brain...mentioning

confidence: 99%

Nutritional roles and therapeutic potentials of dietary sphingomyelin in brain diseases

Alashmali

2024

J. Clin. Biochem. Nutr.

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Sphingolipids have recently gained interest as potential players in variety of diseases due to their import roles in human body particularly, the brain. As sphingomyelin is the most common type of sphingolipids, deficits in its distribution to brain cells may contribute to neurological anomalies. However, data is limited regarding the impact of different levels of dietary sphingomyelin intake on neural function especially if this approach can boost cognition and prevent neurological disorders. This review evaluates the effect of dietary sphingomyelin and its metabolites (ceramide and sphingosine-1-phosphate) in animal models and in humans, with a primary focus on its impact on brain health. Additionally, it proposes multiple neuroenhancing effects of sphingomyelin-rich diet. This presents an opportunity to stimulate further research that aims to determine the therapeutic value of dietary sphingomyelin in preventing, improving or slowing the progression of central nervous system disorders.

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“…It is noteworthy that the BBB is not the only barrier impacted by stress. Several studies have found that intestinal barriers are leaky among patients with psychiatric disease ( Wasiak and Gawlik-Kotelnicka, 2023 ). Immune cells are critically involved in the extent of intestinal barrier integrity.…”

Section: Mechanisms By Which B Cells Migrate To Access and Remain At ...mentioning

confidence: 99%

B cells and the stressed brain: emerging evidence of neuroimmune interactions in the context of psychosocial stress and major depression

Engler-Chiurazzi

2024

Front. Cell. Neurosci.

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The immune system has emerged as a key regulator of central nervous system (CNS) function in health and in disease. Importantly, improved understanding of immune contributions to mood disorders has provided novel opportunities for the treatment of debilitating stress-related mental health conditions such as major depressive disorder (MDD). Yet, the impact to, and involvement of, B lymphocytes in the response to stress is not well-understood, leaving a fundamental gap in our knowledge underlying the immune theory of depression. Several emerging clinical and preclinical findings highlight pronounced consequences for B cells in stress and MDD and may indicate key roles for B cells in modulating mood. This review will describe the clinical and foundational observations implicating B cell-psychological stress interactions, discuss potential mechanisms by which B cells may impact brain function in the context of stress and mood disorders, describe research tools that support the investigation of their neurobiological impacts, and highlight remaining research questions. The goal here is for this discussion to illuminate both the scope and limitations of our current understanding regarding the role of B cells, stress, mood, and depression.

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Intestinal permeability and its significance in psychiatric disorders – A narrative review and future perspectives

Cited by 20 publications

References 115 publications

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Nutritional roles and therapeutic potentials of dietary sphingomyelin in brain diseases

B cells and the stressed brain: emerging evidence of neuroimmune interactions in the context of psychosocial stress and major depression

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