Intestinal permeability and small intestine bacterial overgrowth in excess weight adolescents

Cortez, Ana Paula Bidutte; Fisberg, Mauro; Morais, Mauro Batista de

doi:10.1111/ijpo.12741

Cited by 8 publications

(6 citation statements)

References 47 publications

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“…To the best of our knowledge, this study represents the first investigation to comprehensively examine a broad range of anthropometric parameters, including muscle mass, skeletal mass, body protein, mineral bone content, and total body water with SIBO type. In previous studies addressing similar research questions, the correlations observed in SIBO patients were mainly related to age, height, BMI, body weight, body fat, and visceral fat [ 32 , 33 , 34 , 35 ]. However, in our study, we demonstrated that the high H 2 gas production in the H+/M+ group was inversely correlated with BMI, body weight, and body fat in kg or in %.…”

Section: Discussionmentioning

confidence: 93%

Influence of Body Composition and Specific Anthropometric Parameters on SIBO Type

Wielgosz-Grochowska,

Domanski,

Drywień

2023

Nutrients

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Recent observations have shown that Small Intestinal Bacterial Overgrowth (SIBO)affects the host through various mechanisms. While both weight loss and obesity have been reported in the SIBO population due to alterations in the gut microbiome, very little is known about the influence of SIBO type on body composition. This study aimed to evaluate whether there is a link between the three types of SIBO: methane dominant (M+), hydrogen dominant (H+), and methane–hydrogen dominant (H+/M+) and specific anthropometric parameters. This observational study included 67 participants (W = 53, M = 14) with gastrointestinal symptoms and SIBO confirmed by lactulose hydrogen–methane breath tests (LHMBTs) using the QuinTron device. Participants underwent a body composition assessment by Bioelectrical Impedance Analysis (BIA) using the InBody Analyzer. In the H+/M+ group, body weight (p = 0.010), BMI (p = 0.001), body fat in kg (p = 0.009), body fat in % (p = 0.040), visceral fat (p = 0.002), and mineral bone content (p = 0.049) showed an inverse correlation with hydrogen (H2) gas production. These findings suggest that body weight, BMI, body fat, and mineral bone content may be inversely linked to the production of hydrogen and the risk of hydrogen–methane SIBO.

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Section: Discussionmentioning

confidence: 93%

Influence of Body Composition and Specific Anthropometric Parameters on SIBO Type

Wielgosz-Grochowska,

Domanski,

Drywień

2023

Nutrients

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“…The serum zonulin assay has been considered as an easy to perform surrogate marker of dysfunctional intestinal barrier, suitable also in paediatric age. 10,11 Zonulin is a protein that reversibly controls intestinal permeability by regulating the binding between the epithelial cells of the intestinal mucosa. 4 Intestinal dysbiosis, characteristic of subjects who consume a high-fat and low-fibre diet, 12 stimulates the production of zonulin by the lamina propria of the intestinal epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Altered intestinal permeability is not easy to assess. The serum zonulin assay has been considered as an easy to perform surrogate marker of dysfunctional intestinal barrier, suitable also in paediatric age 10,11 . Zonulin is a protein that reversibly controls intestinal permeability by regulating the binding between the epithelial cells of the intestinal mucosa 4 .…”

Section: Discussionmentioning

confidence: 99%

Serum zonulin as an index of glucose dysregulation in children and adolescents with overweight and obesity

et al. 2022

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Summary Increased intestinal permeability has an important role in metabolic dysregulation. In this cross‐sectional study, we examined whether serum intestinal permeability marker zonulin and related pro‐inflammatory molecules were associated with the oral disposition index, a predictor for the development of type 2 diabetes, in a cohort of children and adolescents with overweight and obesity. Ninety‐two children and adolescents were recruited [Male: 43; 12.7 (2.35) years; BMI SDS: 2.7 (0.96)]. Anthropometric and clinical parameters, lipid profile, glucose metabolism and plasma levels of zonulin, lipopolysaccharide‐binding protein and Interleukin‐6 were measured. We found an association between oral disposition index and zonulin (β = −0.243; p = 0.019) and age (β = −0.307; p = 0.004), independent of sex and BMI SDS [R2 = 0.16; p = 0.005]. Our results show an association between serum zonulin concentration and oral disposition index supporting the hypothesis of increased intestinal permeability as a possible risk factor for glucose metabolism dysregulation in children and adolescents with obesity.

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“…Gut microbiome imbalance has an important relationship with the development of fatty liver disease, cirrhosis, and primary sclerosing cholangitis [16][17][18][19][20][21]. Recent studies have shown that intestinal microbes drive liver inflammatory stimuli through the "gut-liver axis" to accelerate liver carcinogenesis [22,23].In addition, gut microbiome can influence the development and progression of hepatocellular carcinoma by regulating the expression and accumulation of immune cells [24].…”

Section: Introductionmentioning

confidence: 99%

Recurrence of Early Hepatocellular Carcinoma after Surgery May Be Related to Intestinal Oxidative Stress and the Development of a Predictive Model

Liang

Chen

et al. 2022

Oxidative Medicine and Cellular Longevity

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Background. Early stage hepatocellular carcinoma (HCC) has a high recurrence rate after surgery and lacks reliable predictive tools. We explored the potential of combining enhanced CT with gut microbiome to develop a predictive model for recurrence after early HCC surgery. Methods. A total of 112 patients with early HCC who underwent hepatectomy from September 2018 to December 2020 were included in this study, and the machine learning method was divided into a training group ( N = 71 ) and a test group ( N = 41 ) with the observed endpoint of recurrence-free survival (RFS). Features were extracted from the arterial and portal phases of enhanced computed tomography (CT) images and gut microbiome, and features with minimum absolute contraction and selection operator regression were created, and the extracted features were scored to create a preoperative prediction model by using the multivariate Cox regression analysis with risk stratification analysis. Results. In the study cohort, the model constructed by combining radiological and gut flora features provided good predictive performance ( C index, 0.811 (0.650-0.972)). The combined radiology and gut flora-based model constructed risk strata with high, intermediate, or low risk of recurrence and different characteristics of recurrent tumor imaging and gut flora. Recurrence of early stage hepatocellular carcinoma may be associated with oxidative stress in the intestinal flora. Conclusions. This study successfully constructs a risk model integrating enhanced CT and gut microbiome characteristics that can be used for the risk of postoperative recurrence in patients with early HCC. In addition, intestinal flora associated with HCC recurrence may be involved in oxidative stress.

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Intestinal permeability and small intestine bacterial overgrowth in excess weight adolescents

Cited by 8 publications

References 47 publications

Influence of Body Composition and Specific Anthropometric Parameters on SIBO Type

Influence of Body Composition and Specific Anthropometric Parameters on SIBO Type

Serum zonulin as an index of glucose dysregulation in children and adolescents with overweight and obesity

Recurrence of Early Hepatocellular Carcinoma after Surgery May Be Related to Intestinal Oxidative Stress and the Development of a Predictive Model

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