Intestinal permeability in patients with adverse reactions to food

Ventura, M. T.; Polimeno, Lorenzo; Amoruso, A.; Gatti, Francesco G.; Annoscia, E.; Marinaro, Mariarosaria; Leo, Elisabetta; Matino, Matteo; Buquicchio, Rosalba; Бонини, С.; Tursi, A.; Francavilla, A.

doi:10.1016/j.dld.2006.06.012

Cited by 127 publications

(120 citation statements)

References 19 publications

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“…81,[161][162][163] Furthermore, unpublished observations from our group indicate that a single intravenous bolus of CRF (100 g) increased intestinal permeability, measured as the blood-to-lumen albumin ratio, in healthy subjects and in IBS patients through mast cell activation. 164 In the same line, increased intestinal permeability and stress/ CRF axis have also been involved in the pathophysiology of food allergy, as these patients display an enhancement of intestinal permeability even in the absence of food allergens 165 and stress facilitates sensitization to luminal antigens. 82 In fact, patients following immunosuppressive treatment have been shown to develop new-onset food allergies that may be related to the increase in intestinal permeability induced by treatment.…”

Section: Clinical Consequences Of Stress/ Corticotropin-releasing Facmentioning

confidence: 96%

Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

Rodiño-Janeiro¹,

Alonso-Cotoner²,

Pigrau³

et al. 2015

J Neurogastroenterol Motil

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The interface between the intestinal lumen and the mucosa is the location where the majority of ingested immunogenic particles face the scrutiny of the vast gastrointestinal immune system. Upon regular physiological conditions, the intestinal microflora and the epithelial barrier are well prepared to process daily a huge amount of food-derived antigens and non-immunogenic particles. Similarly, they are ready to prevent environmental toxins and microbial antigens to penetrate further and interact with the mucosal-associated immune system. These functions promote the development of proper immune responses and oral tolerance and prevent disease and inflammation. Brain-gut axis structures participate in the processing and execution of response signals to external and internal stimuli. The brain-gut axis integrates local and distant regulatory networks and supersystems that serve key housekeeping physiological functions including the balanced functioning of the intestinal barrier. Disturbance of the brain-gut axis may induce intestinal barrier dysfunction, increasing the risk of uncontrolled immunological reactions, which may indeed trigger transient mucosal inflammation and gut disease. There is a large body of evidence indicating that stress, through the brain-gut axis, may cause intestinal barrier dysfunction, mainly via the systemic and peripheral release of corticotropin-releasing factor. In this review, we describe the role of stress and corticotropin-releasing factor in the regulation of gastrointestinal permeability, and discuss the link to both health and pathological conditions. (J Neurogastroenterol Motil 2015;21:33-50)

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Section: Clinical Consequences Of Stress/ Corticotropin-releasing Facmentioning

confidence: 96%

Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

Rodiño-Janeiro¹,

Alonso-Cotoner²,

Pigrau³

et al. 2015

J Neurogastroenterol Motil

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“…Increased intestinal permeability has been suggested as a potential cause for the breakdown in tolerance, since foodallergic infants have been found to have increased permeability compared with healthy children, as measured by urinary lactulose/mannitol ratio (18). In addition, there are several reports of food allergies developing after solid-organ transplantation, which is believed to be in part due to tacrolimus-induced increases in intestinal permeability (19,20).…”

Section: Pathophysiology Of Food Allergymentioning

confidence: 99%

Food allergy

Wang¹,

Sampson²

2011

J. Clin. Invest.

152

117

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Food allergies affect up to 6% of young children and 3%-4% of adults. They encompass a range of disorders that may be IgE and/or non-IgE mediated, including anaphylaxis, pollen food syndrome, food-protein-induced enterocolitis syndrome, food-induced proctocolitis, eosinophilic gastroenteropathies, and atopic dermatitis. Many complex host factors and properties of foods are involved in the development of food allergy. With recent advances in the understanding of how these factors interact, the development of several novel diagnostic and therapeutic strategies is underway and showing promise. Conflict of interest: Hugh A. Sampson is an investor in and paid consultant forAllertein Therapeutics and an investor in Herbal Springs LLC, a holding company for the patents on FAHF-2. Hugh A. Sampson receives research support from the Food Allergy Initiative, a nonprofit foundation supporting food allergy research.

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“…Increased intestinal permeability is found in 10-25% of healthy first-degree relatives of IBD, celiac disease or Type I diabetes patients, in addition to the patients themselves, indicating that increased intestinal permeability likely precedes the onset of clinical disease (3-6). Cow's milk allergic patients also have increased intestinal permeability at baseline (33), and a link between increased intestinal permeability and the development of new-onset food allergies has been identified in patients after organ transplantation (34). Notably, these changes in IBD patients have been associated with modified levels of intestinal chymase-positive mast cells (35).…”

Section: Mcpt7 Andmentioning

confidence: 99%