Intestinal permeation enhancement of docetaxel encapsulated into methyl-β-cyclodextrin/poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan

Mazzaferro, Silvia; Bouchemal, Kawthar; Skanji, Rym; Gueutin, Claire; Chacun, Hélène; Ponchel, Gilles

doi:10.1016/j.jconrel.2012.08.005

Cited by 56 publications

(24 citation statements)

References 27 publications

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“…To eliminate toxicities associated with the formulation, polymeric nanoparticles, emulsions and liposomes have been applied as drug delivery systems (DDSs) (Hwang et al, 2008;Qiu et al, 2008;Yanasarn et al, 2009;Wang et al, 2011;Ernsting et al, 2012;Mazzaferro et al, 2012;Tang et al, 2014). Studies investigating toxicities associated with first generation DTX products have received a lot of attention, especially those looking for better alternative formulations that are less toxic and provide better penetration and targeting to the tumor tissues (Hennenfent & Govindan, 2006).…”

mentioning

confidence: 99%

Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence

Ding

Yang

et al. 2015

Drug Delivery

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The aim of this study was to develop docetaxel (DTX)-loaded poly-d,l-lactide (PDLLA) nanofibers and evaluate their therapeutic effect in preventing local breast cancer recurrence. DTX was incorporated into biodegradable PDLLA nanofibers by electrospinning. The surface morphology of the DTX/PDLLA nanofibers was characterized using scanning electron microscopy and wide angle X-ray diffraction. The in vitro release behavior of DTX from the fiber mats was also studied in detail. The cytotoxicity of DTX/PDLLA nanofibers was evaluated by MTT assay in 4T1 breast cancer cells. Flow cytometry revealed that DTX/PDLLA nanofibers exhibited apoptotic activity in 4T1 cells. In vivo antitumor efficacy of DTX/PDLLA nanofibers was evaluated in BALB/c mice bearing local breast tumors. Locoregional recurrence after primary tumor resection decreased obviously in mice treated with subcutaneously (16.7%) administered DTX-loaded PDLLA nanofibers, compared with the blank PDLLA nanofibers (88.9%), systemic (75.0%) or locally (77.8%) administered DTX and the control group (100%) (p < 0.05). Finally, after subcutaneous transplantation in mice, the DTX/PDLLA scaffolds presented excellent biocompatibility, as exhibited by the minimal presence of inflammatory cells in the region surrounding the scaffolds. Our results suggest that DTX/PDLLA nanofibers could have great potential for clinical application requiring local chemotherapy.

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confidence: 99%

Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence

Ding

Yang

et al. 2015

Drug Delivery

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“…The synthesized NPs showed a good enhancement for permeation during in vitro studies. 85 Sulfobutylether-β-cyclodextran and chitosan-based NPs were developed for the coadministration of DTX and berbamine. The newly formed NPs showed good drug loading and release kinetics and improved cytotoxicity against MCF-7 cells.…”

Section: Polymeric Npsmentioning

confidence: 99%

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Sohail

Rehman

Sarwar

et al. 2018

IJN

106

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The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability, gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus, chemotherapeutic drugs, including Docetaxel, are administered via an intravenous route, which poses many disadvantages of its own. Recent advances in pharmaceutical research have focused on designing new and efficient drug delivery systems for site-specific targeting, thus leading to improved bioavailability and pharmacokinetics. A decent number of studies have been reported for the safe and effective oral delivery of Docetaxel. These nanocarriers, including liposomes, polymeric nanoparticles, metallic nanoparticles, hybrid nanoparticles, dendrimers and so on, have shown promising results in research papers and clinical trials. The present article comprehensively reviews the research efforts made so far in designing various advancements in the oral delivery of Docetaxel. Different strategies to improve oral bioavailability, prevent first-pass metabolism and inhibition of efflux pumping leading to improved pharmacokinetics and anticancer activity are discussed. The final portion of this review article presents key issues such as safety of nanomaterials, regulatory approval and future trends in nanomedicine research.

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“…Nanoparticles coated with chitosan and thiolated chitosan were prepared by anionic emulsion polymerization according to previous works (9)(10)(11)14). Briefly, 0.069 g of mixtures of chitosan and thiolated chitosan (Chito20/Chito20-TBA) at different thiol proportion (100/0, 75/25, 50/50 and 25/ 75 wt%) were dissolved in 5 mL of 0.2 M nitric acid in a glass tube at 40°C under vigorous magnetic stirring and argon bubbling.…”

Section: Nanoparticle Preparationmentioning

confidence: 99%

“…The nanoparticles are composed of poly(isobutylcyanoacrylate) (PIBCA) core coated with a mixture of chitosan and thiolated chitosan. Among the characteristics of these nanoparticles, mucoadhesive properties due to chitosan and thiolated chitosan are the most important ones when foreseen mucosal administration (9)(10)(11). The nanoparticles were included into a vehicle composed of a thermosensitive pluronic® F127 hydrogel ((ethylene oxide) 97 (propylene oxide) 69 (ethylene oxide) 97 block copolymers).…”

Section: Introductionmentioning

confidence: 99%

Drug-Free Chitosan Coated Poly(isobutylcyanoacrylate) Nanoparticles Are Active Against Trichomonas vaginalis and Non-Toxic Towards Pig Vaginal Mucosa

et al. 2014

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Intestinal permeation enhancement of docetaxel encapsulated into methyl-β-cyclodextrin/poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan

Cited by 56 publications

References 27 publications

Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence

Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Drug-Free Chitosan Coated Poly(isobutylcyanoacrylate) Nanoparticles Are Active Against Trichomonas vaginalis and Non-Toxic Towards Pig Vaginal Mucosa

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