Intestinal Tuberculosis: Return of an Old Disease

Horvath, Karen D.; Whelan, Richard L.

doi:10.1111/j.1572-0241.1998.207_a.x

Cited by 251 publications

(141 citation statements)

References 47 publications

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“…The infection causing abdominal tuberculosis may be contracted hematogenously or by the ingestion of sputum containing tuberculosis bacilli, the consumption of contaminated milk or food products, or by direct spread from neighboring structures (16). Peritoneal tuberculosis, with no gastrointestinal lesions, is always secondary and results from reactivation of a latent peritoneal focus from previous hematogenous spread or as a part of active pulmonary tuberculosis with miliary dissemination.…”

Section: Discussionmentioning

confidence: 99%

Assessment of 35 children with abdominal tuberculosis

Kılıç

Somer²,

Törün³

et al. 2015

Turk J Gastroenterol

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Background/Aims: To contribute to the diagnosis and treatment of pediatric abdominal tuberculosis cases by assessing the clinical, laboratory, and radiological features of patients who presented at our clinic and were diagnosed with abdominal tuberculosis. Materials and Methods: Clinical, laboratory, and radiological features were reviewed retrospectively for 35 patients diagnosed with abdominal tuberculosis and followed up at the Pediatric Infectious Diseases Clinic between January 1987 and August 2012. Results: The study group included 16 female (45.7%) and 19 male (54.3%) patients with an age range of 6 months to 16 years (mean: 9.77±4.36 years). Twenty-nine patients were diagnosed with tuberculosis peritonitis, five patients with intestinal tuberculosis, and one patient with pelvic tuberculosis. The most common signs and symptoms were ascites, abdominal pain, abdominal distention, weight loss, and fever. Mean duration of the complaints was 109 days (range: 10 days to 3 years). Conclusion: Abdominal tuberculosis is a disease with an insidious course without disease-specific clinical and laboratory signs. When the disease is suspected, laparoscopy or laparotomy could be helpful in diagnosis. Employing ultrasound and computed tomography signs, abdominal tuberculosis should be included in differential diagnoses in regions with a high incidence of tuberculosis when there is abdominal pain, weight loss, ascites, history of contact with individuals with tuberculosis, and positive tuberculin skin test when patients have not been Bacillus Calmette Guerin BCG vaccinated.

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Section: Discussionmentioning

confidence: 99%

Assessment of 35 children with abdominal tuberculosis

Kılıç

Somer²,

Törün³

et al. 2015

Turk J Gastroenterol

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“…El diagnóstico de TB intestinal en ocasiones resulta difícil, pues los hallazgos clínicos y de laboratorio son inespecíficos, y tan solo el 15-25% de los casos presenta compromiso pulmonar concomitante (Faylona & Chung, 1993;Horvath & Whelan). La confirmación diagnóstica requiere demostrar la presencia de M. tuberculosis a partir del tejido afectado o evidencia de TB en otro sitio con presencia de granulomas caseificantes en el intestino, siendo la colonoscopía con obtención de muestras para estudio histopatológico la herramienta diagnóstica más útil (Bhargava et al, 1985;Kim et al, 1998;Shah et al, 1992;Singh et al, 1996).…”

Section: Discussionunclassified

“…La Organización Mundial de la Salud (OMS), estima que un tercio de la población del mundo está infectado por Mycobacterium tuberculosis, representando esta causa el mayor número de muertes de origen infeccioso. Su incidencia es de aproximadamente 8.8 millones, dando cuenta de alrededor de 1,5 millones de muertes anuales (Erhabor et al, 2010;Guth & Kim, 1991;Horvath & Whelan, 1998;WHO, 2008).…”

Section: Introductionunclassified

Tuberculosis Intestinal Secundaria: Hallazgos Morfológicos en un Caso con Desenlace Fatal

2012

Int. J. Morphol.

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. Tuberculosis intestinal secundaria: hallazgos morfológicos en un caso con desenlace fatal. Int. J. Morphol., 30(1):347-353, 2012. RESUMEN:La tuberculosis gastrointestinal (TB GI) representa el 3-5% de todos los casos de TB extrapulmonar, reportándose que hasta el 20% de los sujetos con TB pulmonar presentan manifestaciones extra-pulmonares que incluyen enfermedades intra-abdominales, sin embargo, se desconoce la real incidencia del compromiso intestinal. La región ileocecal representa el sitio anatómico más frecuentemente afectado (85-90%), siendo actualmente la colonoscopía la herramienta diagnóstica de mayor utilidad. Se presentan los hallazgos morfológicos del examen post-mortem de una paciente en estudio por baja de peso y masa en región cecal. La necropsia realizada en la Unidad de Anatomía Patológica del Hospital Hernán Henríquez Aravena de Temuco concluyó una TB pulmonar bilateral con compromiso secundario intestinal y linfonodal.

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“…La caractérisation moléculaire de ces patients a permis d'identifier des défi-cits dans cinq gènes participant aux voies d'activation cellulaire par l'IFN-γ ou l'IL-12 (figure 1), mettant ainsi en évidence le rôle indispensable de l'IFN-γ et de son principal inducteur, l'IL-12 dans le contrôle des infections mycobactériennes chez l'homme. [43]. L'immunité indépendante de l'IL-12 apparaît ainsi insuffisante pour le contrôle de l'infection par des mycobactéries plus virulentes comme M. tuberculosis [41].…”

Section: Frédéric Altare Jean-laurent Casanovaunclassified