Intestinal ulceration, obstruction, and haemorrhage in congenital syphilis

Ajayi, N. A.; Marven, Sean; Kaschula, R. O. C.; Millar, A. J. W.; Rode, H.

doi:10.1007/s003830050608

Cited by 13 publications

(13 citation statements)

References 3 publications

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“…Although intestinal obstruction has previously been reported during fetal (2,3) and neonatal life (4,5), this manifestation of congenital syphilis is uncommon. Although intestinal obstruction has previously been reported during fetal (2,3) and neonatal life (4,5), this manifestation of congenital syphilis is uncommon.…”

Section: Answermentioning

confidence: 89%

“…Although intestinal obstruction has previously been reported during fetal (2,3) and neonatal life (4,5), this manifestation of congenital syphilis is uncommon. Two mechanisms are reported: mechanical obstruction by inspissated meconium (4); and stenosis (4,5) secondary to syphilitic vasculitis. All were preterm infants; four developed respiratory distress (three pneumonia, one not specified).…”

Section: Answermentioning

confidence: 89%

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2006

J. pediatr. gastroenterol. nutr.

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A 1940-gram male infant was delivered by emergency Caesarean section because of fetal distress at a Level 1 maternity hospital. The mother had no prenatal care and neither her medical history nor her serology was known. The mother presented in active premature labor, presumably at approximately 34 weeks gestation. After resuscitation requiring intubation and tracheal administration of epinephrine, the baby was referred to the neonatal intensive care unit of Debrousse Hospital with a diagnosis of prematurity, respiratory distress syndrome and abdominal distension, possibly secondary to intestinal obstruction.The chest radiograph was consistent with the diagnosis of hyaline membrane disease. Despite exogenous surfactant instillation and a trial of high frequency oscillation, the infant`s respiratory function failed to improve. The abdominal distension was thought to exacerbate this problem. The abdominal wall was tender, painful and inflamed. The plain film showed limited gas in the intestinal tract ( Fig. 1), and the ultrasound scan showed ascites without dilation of the small bowel.Laboratory findings showed metabolic acidosis (pH = 7.16; base excess = 12), leukocytosis (21,000/mL), thrombocytopenia (18,000/L), hypoglycemia (glucose G1.1 mmol/L) and a coagulation deficit (prothrombin activity G50% despite intravenous vitamin K administration). Antibiotics were started and continued in association with transfusion of platelets and fresh frozen plasma. A laparotomy was performed on the second day of life. No obstruction was obvious at laparotomy. The liver was enlarged and dark in color. Culture of the peritoneal fluid was sterile. In absence of obvious diagnosis we performed infectious and metabolic evaluations and bone radiographs (Fig. 2).What is the likely diagnosis? A. Hirschsprung disease. B. Congenital syphilis. C. Infectious liver failure. D. Inborn errors of metabolism.

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Section: Answermentioning

confidence: 89%

Section: Answermentioning

confidence: 89%

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2006

J. pediatr. gastroenterol. nutr.

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“…This pattern is most prominent in the small bowel [180,182,183]. This pattern is most prominent in the small bowel [180,182,183].…”

Section: Pathologymentioning

confidence: 99%

Syphilis

Kollmann¹,

Dobson²

2011

Infectious Diseases of the Fetus and Newborn

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“…The more severe lesions are detected in intrauterine deaths (Table 3) [85]. A heavy intestinal inflammation may cause ulceration and stenosis in postnatal life [86].…”

Section: Pathologymentioning

confidence: 99%

Pathogenesis and Pathology of Hematogenous Infections of the Fetus and Newborn

Bittencourt

Garcia

2002

Pediatric Pathology & Molecular Medicine

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The earlier infections occur in intrauterine life the more severe are they. When the infection develops during embryogenesis, the lesions are much more serious, sometimes causing disruptions (malformations). At this time the organs are not completely formed and microorganisms may interfere with organogenesis to such an extent that the development of the functions necessary for viability become impaired. Infection acquired in utero may result in resorption of the embryo, abortion, stillbirth, neonatal death, intrauterine growth retardation (IUGR), or prematurity. The infected newborns commonly are apparently normal at birth but they may develop a late onset disease. Otherwise, neonates presenting symptomatology may derelop untoward sequelae.

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Intestinal ulceration, obstruction, and haemorrhage in congenital syphilis

Cited by 13 publications

References 3 publications

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Syphilis

Pathogenesis and Pathology of Hematogenous Infections of the Fetus and Newborn

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