Intima‐medial thickness homogeneity in the common carotid artery: Measurement method and preliminary clinical study

Xiao, Cheng; Zhou, Yuan; Ye, Jin; Li, Guokuan; Wang, Hua; Song, Enmin

doi:10.1002/jcu.21987

Cited by 5 publications

(7 citation statements)

References 30 publications

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“…Carotid IMR measured by the software system is consistent with the results of manual measurement in previous studies . The Bland‐Altman test showed that the measurement parameters were repeatable and could stably reflect the morphologic changes of the carotid intima‐media.…”

Section: Discussionsupporting

confidence: 84%

“…Carotid IMR measured by the software system is consistent with the results of manual measurement in previous studies. 7 The Bland-Altman test showed that the measurement parameters were repeatable and could stably reflect the morphologic changes of the carotid intima-media. Studies by Ishizu et al 12 and Schmidt-Trucksäss et al 13 demonstrated that carotid IMR was significantly increased in patients with coronary heart disease compared with healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

“…However, IMT can only reflect the single‐point thickness or average thickness of the intima‐media in arteries, and the morphologic changes of the intima‐media are poorly evaluated. Cheng et al found that carotid IMR increased in groups with a high risk of cardiovascular disease before IMT. The aim of this study was to investigate the relationships between carotid IMR and arterial stiffness and risk factors in hypertensive patients with normal carotid IMT.…”

Section: Discussionmentioning

confidence: 99%

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Carotid Intima–Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima‐Media Thickness

Xie

Zhang

et al. 2018

J of Ultrasound Medicine

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Objectives To investigate carotid intima‐media roughness (IMR) in hypertensive patients with normal carotid intima‐media thickness (IMT) using automatic identification software and the correlation between carotid IMR and risk factors. Methods This case‐control study comprised 61 hypertensive patients with normal carotid IMT and 51 control participants. Carotid IMR, carotid IMT, pulsed wave velocity (PWV), stiffness (β), and arterial compliance were determined by carotid ultrasound and image postprocessing using an automatic identification program and echo‐tracking analysis software. Results Carotid IMR, mean carotid IMT, maximum carotid IMT, β, and PWV in the hypertension group were higher than those in the control group (58.24 versus 34.61 μm, 641.17 versus 576.48 μm, 746.82 versus 640.55 μm, 9.42 versus 7.35, and 7.10 versus 5.86 m/s, respectively; P < .05), and arterial compliance was lower than that in the control group (0.70 versus 0.95 mm2/kPa; P < .05). Intima‐media roughness was correlated with maximum IMT, mean IMT, PWV, β, age, diagnosis of hypertension for greater than 1 year, and pulse pressure. Multivariate logistic regression showed that age, diagnosis of hypertension for greater than 1 year, and pulse pressure were influential factors for IMR in hypertensive patients, with odds ratios of 6.719 (95% confidence interval, 1.658–27.221; P = .008), 4.726 (95% confidence interval, 1.174–19.022; P = .029), and 3.998 (95% confidence interval, 1.033–15.466; P = .045), respectively. Conclusions Carotid IMR and the elasticity index have important clinical importance in evaluating the risk of early atherosclerosis in hypertensive populations.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Carotid Intima–Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima‐Media Thickness

Xie

Zhang

et al. 2018

J of Ultrasound Medicine

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“…Most studies use cIMT ≥ 1 mm as evidence of arterial thickening (Cheng et al, 2012). However, there is controversy regarding the cutoff point for atherosclerotic plaque.…”

Section: Assessment Of Atherosclerotic Plaquementioning

confidence: 99%

Association of Carotid Intima–media Thickness and Atherosclerotic Plaque with Periodontal Status

Liu

et al. 2014

J Dent Res

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Studies have suggested an association between clinical/subclinical atherosclerosis and periodontal status. The purpose of this study was to investigate the association among maximal carotid intima–media thickness (cIMT), atherosclerotic plaque, and periodontal status in Chinese elderly patients. A cross-sectional study was conducted of 847 participants (age, 70.64 ± 9.03 yr) with ≥10 teeth. A questionnaire survey, routine biochemical tests, a periodontal examination, and maximal cIMT measurement were performed for each. Traditional risk factors for atherogenesis were considered in the statistical analysis. Mean plaque index, which reflects oral hygiene, was correlated with maximal cIMT and atherosclerotic plaque in the study sample overall (β = 0.068, p < .001; OR = 2.051, p < .001) and in euglycemic participants (β = 0.066, p = .008; odds ratio = 2.122, p = .009). In hyperglycemic participants, multiple linear regression analysis ( p = .006) and multivariate logistic regression analysis ( p = .025) revealed a linear and dose-dependent association between mean clinical attachment loss and maximal cIMT after adjustment for traditional risk factors. Each 1-mm increase in mean clinical attachment loss corresponded to a 0.018-mm increase in maximal cIMT. The risk of atherosclerotic plaque increased by 18.3% with each 1-mm increase in mean clinical attachment loss. Other indicators of periodontal exposure, including percentage of sites with attachment loss ≥ 3 to 5 mm (3%-5%), were also correlated with cIMT and atherosclerotic plaque in hyperglycemic patients. In this elderly population, a linear and dose-dependent association among mean clinical attachment loss, attachment loss 3% to 5%, maximal cIMT, and atherosclerotic plaque was verified in those with hyperglycemia. Poor oral hygiene was correlated with maximal cIMT and atherosclerotic plaque in all participants, including those with normal blood glucose.

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“…Our objective was to develop a tissue classification technique that characterizes the early changes in the far wall region (FWR) of the common carotid artery (CCA) in order to identify patients whose features are (“ Sym ” class ) or not (“ Asym ” class ) associated with symptoms, before the plaque onset, because studies have shown that progressive atherosclerotic lesions start with intimal thickening . We used IMT variability, or IMTV poly , as one of these features . Manual measurement of IMT from B‐mode images is time‐consuming and prone to intra‐ and inter‐observer variability.…”

mentioning

confidence: 99%

An automated technique for carotid far wall classification using grayscale features and wall thickness variability

Acharya

Sree²,

Molinari

et al. 2014

J of Clinical Ultrasound

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Intima‐medial thickness homogeneity in the common carotid artery: Measurement method and preliminary clinical study

Abstract: IMTH is a promising approach for the assessment of atherosclerosis, in addition to conventional IMT measurement. Further clinical studies are needed to assess its clinical usefulness.

Cited by 5 publications

References 30 publications

Carotid Intima–Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima‐Media Thickness

Carotid Intima–Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima‐Media Thickness

Association of Carotid Intima–media Thickness and Atherosclerotic Plaque with Periodontal Status

An automated technique for carotid far wall classification using grayscale features and wall thickness variability

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