Intoxication after an Isopropyl Alcohol Enema

Barnett, Jay M.; Plotnick, Michael; Fine, Kenneth

doi:10.7326/0003-4819-113-8-638_2

Cited by 7 publications

(1 citation statement)

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“…Substances absorbed vaginally bypass first pass metabolism thereby increasing the bioavailability of the absorbed drugs [3,5]. Although isopropyl alcohol exposure is usually through oral ingestion it has also been reported to be absorbed by inhalation, dermally and rectally [6,7]. Isopropyl alcohol acts as a CNS depressant and with large doses orally it can cause respiratory depression and hypotension and is an irritant to the mucosa potentially causing hematemesis and haemorrhagic gastritis [7,8].…”

Section: Introductionmentioning

confidence: 99%

Are Patients Getting Drunk on Surgical Preparation? Absorption of Isopropyl Alcohol Across Vaginal Mucosa

McGee¹

2019

BJSTR

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Objective: To determine vaginal absorption of isopropyl alcohol solution in patients prepped vaginally with a solution of 2v/w chlorhexidine and 70% isopropyl alcohol. Methods:The amount of vaginal prep was quantified by weighing sponges prior to and after vaginal preparation. A volatile screen quantifying absorption of four known toxins including isopropyl alcohol was conducted at 6 time points -prior to vaginal preparation (baseline), and at 5, 10, 15, 30, and 45 minutes post application. REB approval was obtained for 10 patients; however, the study was stopped after collecting samples on 3 patients to mitigate both patient exposure to blood tests and study cost.Results: Three patients completed the full protocol with all samples collected. Average possible isopropanol dose was 20 ml, recognizing that actual dose was smaller due to spillage onto the external genitalia. The expected absorbed level of isopropyl alcohol ranged across the three patients from 3.17 mmol/L to 8.34 mmol/L. None of the toxicology screens conducted registered an increase above the baseline level of <1.0 mmol/L isopropyl alcohol. Conclusion:Our study shows that isopropyl alcohol absorption is not a concern when solutions containing isopropyl alcohol are used to prepare the vagina for surgery. While absorption of the alcohol is likely occurring, it is being metabolized at a rate at least equal to that absorption, rendering it undetectable in the peripheral blood.

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Section: Introductionmentioning

confidence: 99%

Are Patients Getting Drunk on Surgical Preparation? Absorption of Isopropyl Alcohol Across Vaginal Mucosa

McGee¹

2019

BJSTR

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Isopropyl alcohol

Dhillon

Burg

1995

J of Applied Toxicology

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Note: 1 he roxicology Update represents a brief review o f an often extensive literature base. Only some of the directly related references may be included ISOPROPYL ALCOHOL Synonyms: 2-Propanol; sec-propyl alcohol; propan-2-01: n-propan-2-01; dimethylcarbinol; isopropanol; petrohol; avantine; IPA. CAS no.: 67-63-0. Boiling point: 82.5"C @ 760 mmHg. Color: Colorless liquid. Conversion factor: 1 ppm = 0.4 mg m-?. DOT designation: Flammable/combustible material. Flammability: autoignition temperature. 399°C: flash point. 11.7"C (closed CUP): LEL. 2.5%; UEL, 12.0%. Melting point: -88.5"C. Molecular formula: C3Hx0. Molecular weight: 60.09. Odor: threshold. 90 nig m-.3; recognition. 4@200 ppm (98-490 mg m 3 ) ; pleasant odor. Solubility: > 10% in water; log K,,, = 0.05; soluble in benzene. soluble > Reccvvett

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Isopropyl Alcohol

Jolliff¹

2017

Critical Care Toxicology

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Intoxication after an Isopropyl Alcohol Enema

Cited by 7 publications

References 1 publication

Are Patients Getting Drunk on Surgical Preparation? Absorption of Isopropyl Alcohol Across Vaginal Mucosa

Are Patients Getting Drunk on Surgical Preparation? Absorption of Isopropyl Alcohol Across Vaginal Mucosa

Isopropyl alcohol

Isopropyl Alcohol

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