Intoxications aiguës à Datura stramonium aux urgences

Marc, B.; Martis, Antoine; Moreau, Céline; Arlie, G.; Kintz, Pascal; Leclerc, Johan

doi:10.1016/j.lpm.2007.04.017

Cited by 24 publications

(15 citation statements)

References 8 publications

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“…An example of a 1 H-NMR spectrum of a tropane alkaloid (2) is shown in Figure 4. Carbon-13 ( 13 C-NMR) spectra are also commonly obtained, although these experiments have lower sensitivity in part because NMR-active 13 C nuclei are less abundant than protons. 13 C spectra are also collected as part of DEPT (distortionless enhancement via polarization transfer) experiments.…”

Section: Nuclear Magnetic Resonance (Nmr) Spectroscopymentioning

confidence: 99%

Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Cinelli

Jones

2021

Molecules

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The genus Datura (Solanaceae) contains nine species of medicinal plants that have held both curative utility and cultural significance throughout history. This genus’ particular bioactivity results from the enormous diversity of alkaloids it contains, making it a valuable study organism for many disciplines. Although Datura contains mostly tropane alkaloids (such as hyoscyamine and scopolamine), indole, beta-carboline, and pyrrolidine alkaloids have also been identified. The tools available to explore specialized metabolism in plants have undergone remarkable advances over the past couple of decades and provide renewed opportunities for discoveries of new compounds and the genetic basis for their biosynthesis. This review provides a comprehensive overview of studies on the alkaloids of Datura that focuses on three questions: How do we find and identify alkaloids? Where do alkaloids come from? What factors affect their presence and abundance? We also address pitfalls and relevant questions applicable to natural products and metabolomics researchers. With both careful perspectives and new advances in instrumentation, the pace of alkaloid discovery—from not just Datura—has the potential to accelerate dramatically in the near future.

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Section: Nuclear Magnetic Resonance (Nmr) Spectroscopymentioning

confidence: 99%

Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Cinelli

Jones

2021

Molecules

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“…In addition, we have several reports from other European countries about consuming Brugmansia or Datura for their hallucinogenic effect [28,35,38,65]. Similarly, in Spain, Datura species are mainly used as recreational drugs, but recently the use for criminal purposes is increasing [7].…”

Section: Brugmansia and Datura Poisonings In Europementioning

confidence: 99%

“…Several cases of intoxication by ingestion of various parts of Brugmansia and Datura species have been reported [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Symptoms of intoxication include dilated pupils, confusion, hallucinations, dryness of skin and mucous membranes, increased blood pressure and heart rate, and increased body temperature [11,36,[42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Worldwide poisoning potential of Brugmansia and Datura

Kerchner

Farkas

2019

Forensic Toxicol

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Purpose The toxicological significance of human exposures to angel's trumpet plants (Brugmansia and Datura species) in their native American and non-native regions (Asia, Africa, and Europe) was highlighted, and the poisoning potential of various plant parts was discussed. Methods Nearly 2500 cases of human plant exposures, reported to the Hungarian Toxicological Information Service between 2005 and 2017, were analyzed and compared to data of other toxicology centers in America, Asia and Europe, focusing on exposures to tropane alkaloid-containing plants. Results In America, Brugmansia and Datura were not among the 15 most common plant ingestions, but were responsible for 20% of the fatal outcomes in a 26-year period. In Asia, the anticholinergic toxidrome, related to Brugmansia and Datura, was among the most frequent plant-related intoxications, which included accidental ingestion, improper use of herbal medicines and plant abuse. In Europe, Brugmansia and Datura were among the top four plant taxa causing intoxications with major outcomes, being the leading plants ingested for their hallucinogenic properties, and accounted for 60% of abuse cases in Hungary in a 13-year period. Use of Brugmansia and Datura for criminal purposes has been reported from America, Asia and Europe. The concentrations of tropane alkaloids vary with the species, seasons and plant parts. Ingestion of the seeds and flowers has the highest toxicological significance, but exposure to the leaves and floral nectar can also cause intoxication. Conclusions Angel's trumpets have high toxicological significance both in their native and non-native regions, mainly due to their hallucinogenic property and accidental ingestion.

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“…Lors d'une consultation de suivi, nous leur avons demandé de commenter brièvement l'expéri-ence de consommation et l'évolution de la symptomatologie. L'aspect clinique initial consistait en un syndrome anticholinergique (tableau I), tel que décrit dans la littérature [1][2][3]. Les 2 patients ont été hospitalisés respectivement 6 et 20 heures après ingestion pour une durée de 8 et 24 heures.…”

Section: Observationsunclassified