Intoxikationen

Pentschew, A.

doi:10.1007/978-3-642-94735-3_47

Cited by 6 publications

(2 citation statements)

References 1,247 publications

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“…Typical clinical signs and symptoms of methylmercury poisoning, consisting of ataxia, impairment of speech, and constriction of bilateral visual field, were first defined by Hunter and Russell (17,23). Diagnostic guidelines for Minamata disease have been published recently (51).…”

Section: Discussionmentioning

confidence: 99%

Differential Diagnosis between Organic and Inorganic Mercury Poisoning in Human Cases-The Pathologic Point of View

et al. 1999

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Differences in pathology were found between acute and chronic exposure to methylmercury, mercury vapor, and inorganic mercury. Characteristic pathologic changes produced by organic mercury in the brain have previously been described in patients with Minamata disease. The brains of patients who presented with acute onset of symptoms and died within 2-mo showed loss of neurons with reactive proliferation of glial cells, microcavitation, vascular congestion, petechial hemorrhage, and edema in the cerebral cortices, predominantly in the calcarine, pre- and postcentral, and transverse temporal cortices and in the cerebellar cortex. The neuropathologic changes in the patients with acute onset of symptoms who survived for a long period (>10 yr) were also included neuronal loss with reactive proliferation of glial cells in similar anatomic locations. The neuropathologic changes in patients with inorganic mercury poisoning are quite different. Autopsies performed on 3 individuals with fatal cases of acute inorganic mercury poisoning who were exposed to mercury vapor for about 2 wk revealed diffuse organized pneumonia, renal cortical necrosis, disseminated intravascular coagulopathy, and infarctions in the brain and kidneys. In 2 other patients who worked in mercury mines for about 10 yr and who suffered from chronic inorganic poisoning, no specific lesions were demonstrated in the brain. However, the assay and the histochemistry of mercury revealed that inorganic mercury was present in the brain in all 3 groups irrespective of the brain lesions and the duration of clinical signs.

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Section: Discussionmentioning

confidence: 99%

Differential Diagnosis between Organic and Inorganic Mercury Poisoning in Human Cases-The Pathologic Point of View

et al. 1999

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“…Vielleicht werden die Membra nen der Blut/Liquorschrankc durch die neuen Chemotherapcutica wie 6-Mercaptopurin und die Corticosteroide irgendwie so ver ändert, daß es auch jenseits dieser Schranke zur metaplastischcn leukämischen Entartung kommt. Pentschew (32) Ludwig (27) Im Hinblick auf diese letzteren Ausführungen läßt sich auch bezüglich der Therapie kurz das Wesentlichste sagen. Die Cyto statica müssen intrathecal verabreicht werden, w'enn man aus ihrer Anwendung bei der intracraniellen Ausbreitung der Leukämien Nutzen ziehen will.…”

Section: Diskussionunclassified