Über die intracranielle Ausbreitung der Leukämien unter besonderer Berücksichtigung der leukämischen Meningopathie

Deafness in leukemia was first described by Donne! and by Vidal. 2 Politzer" was the first to do histological studies on the temporal bones of a patient with deafness associated with leukemia. Subsequent cases were reported by Steinbrugge," Wagenhauser" and Schwabach.6 The latter studied histologically five cases of his own and reviewed ten cases from the literature. He stated that two of his own five cases had clinical ear symptoms without pathological changes in the temporal bones. Alexander,' after having studied 15 cases histologically, stressed the very high percentage of involvement of the middle and inner ear in leukemia. One other case was reported by Nishio."Alexander's? observations were confirmed by Druss" who studied 148 patients clinically and four temporal bones histologically. He found clinical involvement of the ear in 16.5 percent of the patients. He observed the following otologic signs: 1) ulceration of the skin of the external auditory meatus with and without hemorrhage, 2) hemorrhage into the middle ear and the mastoid with and without infection, and 4) mixed hearing loss and facial nerve palsy. Druss" observed that pathological findings in the temporal bones, such as infiltration of the middle ear mucosa, were not always associated with clinical symptoms. Other cases were histologically examined by Cawthorne;'? Hallpike," de Stefani'" and Schuknecht et aP3 Shambrom and Finch!' found otologic symptoms in 32 of 100

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Über die intracranielle Ausbreitung der Leukämien unter besonderer Berücksichtigung der leukämischen Meningopathie

Cited by 2 publications

References 6 publications

Extramedulläre Blutbildung in der Milz, insbesondere bei Knochenmarkmetastasierung

Extramedulläre Blutbildung in der Milz, insbesondere bei Knochenmarkmetastasierung

XXXII The Temporal Bone in Leukemia Histological Studies

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