Intra- and Interoperator Variations in Region-of-Interest Drawing and Their Effect on the Measurement of Glomerular Filtration Rates

White, D. R.R.; Houston, A. S.; Sampson, W. F. D.; Wilkins, Graham P.

doi:10.1097/00003072-199903000-00008

Cited by 45 publications

(23 citation statements)

References 6 publications

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“…In contrast to some studies, which have reported signifi cant variations [11][12][13] , this study did not show any statistically signifi cant difference in the estimated values from manually drawn reigions of interest among the three experienced technologists, indicating that the nuclear medicine procedures studied are reproducible and operator independent. This may be because the commercial packages for image processing have become more advanced and easy to use and the technologists more familiar and skillful in digital image processing.…”

Section: Discussioncontrasting

confidence: 99%

Impact of Operator on Determining Functional Parameters of Nuclear Medicine Procedures

et al. 2006

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Objective: The study was designed to assess the significance of the interoperator variability in theestimation of functional parameters forfour nuclear medicine procedures. Materials andMethods: Three nuclear medicine technologists with varying years of experience processed the following randomly selected 20 cases with diverse functions of each study type: renography, renal cortical scans, myocardial perfusion gated single-photon emission computed tomography (MP-GSPECT) and gated blood pool ventriculography (GBPV). The technologists used the same standard processing routines and were blinded to the results of each other. The means of the values and the means of differences calculated case by case were statistically analyzed by one-way ANOVA. The values were further analyzed using Pearson correlation. Results: The range of the mean values and standard deviation of relative renal function obtained by the three technologists were 50.65 ± 3.9 to 50.92 ± 4.4% for renography, 51.43 ± 8.4 to 51.55 ± 8.8% for renal cortical scans, 57.40 ± 14.3 to 58.30 ± 14.9% for left ventricular ejection fraction from MP-GSPECT and 54.80 ± 12.8 to 55.10 ± 13.1% for GBPV. The difference was not statistically significant, p > 0.9. The values showed a high correlation of more than 0.95. Calculated case by case, the mean of differences ± SD was found to range from 0.42 ± 0.36% in renal cortical scans to 1.35 ± 0.87% in MP-GSPECT with a maximum difference of 4.00%. The difference was not statistically significant, p >0.19. Conclusion: The estimated functional parameters were repro ducible and operator independent as long as the standard processing instructions were followed.

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Section: Discussioncontrasting

confidence: 99%

Impact of Operator on Determining Functional Parameters of Nuclear Medicine Procedures

et al. 2006

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“…Our study does, however, represent one of the largest single-center, prospective studies analyzing resection and survival outcomes of 5-ALA FGS for newly diagnosed GBM in North America using a validated, semiautomated tumor segmentation method. Most studies to date, have used linear diameter or manual segmentation for this end, both of which are heavily user-biased and subject to inaccuracies [30, 36, 38-39, 42]. Lastly, using precision segmentation, this study demonstrates the impact that morphological tumor features (SA, SAVR, and NV%) have on resection and survival outcomes.…”

Section: Discussionmentioning

confidence: 76%

“…Some automated digital-image segmentation techniques have shown promise in measuring pre-operative tumor volumes, but few are designed to evaluate RTV where T1-hyperintense blood products (methemoglobin) and cavity collapse obscure measurements [40-41]. Such structural nuances can be accounted for using manual image contouring; however, this process is time-consuming and suffers from limited reproducibility [39, 42-44]. These limitations often lead to a resection being labeled as a “gross total resection” (GTR, with an RTV of predetermined volume) despite the presence of residual contrast-enhancement, potentially skewing endpoints.…”

Section: Introductionmentioning

confidence: 99%

Semi-Automated Volumetric and Morphological Assessment of Glioblastoma Resection with Fluorescence-Guided Surgery

et al. 2015

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Purpose Glioblastoma (GBM) neurosurgical resection relies on contrast-enhanced MRI-based neuronavigation. However, it is well-known that infiltrating tumor extends beyond contrast enhancement. Fluorescence-guided surgery (FGS) using 5-aminolevulinic acid (5-ALA) was evaluated to improve extent of resection (EOR) of GBMs. Pre-operative morphological tumor metrics were also assessed. Procedures Thirty patients from a Phase II trial evaluating 5-ALA FGS in newly diagnosed GBM were assessed. Tumors were segmented pre-operatively to assess morphological features as well as post-operatively to evaluate EOR and residual tumor volume (RTV). Results Median EOR and RTV were 94.3% and 0.821 cm3, respectively. Pre-operative surface area to volume ratio and RTV were significantly associated with overall survival, even when controlling for the known survival confounders. Conclusions This study supports claims that 5-ALA FGS is helpful at decreasing tumor burden and prolonging survival in GBM. Moreover, morphological indices are shown to impact both resection and patient survival.

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“…Radioisotope methods are accurate, and are known to have a high degree of reproducibility across different centers as long as computing algorithms are similar [29][30][31][32]. These methods have been recommended as routine by some authors [33], although their expense and logistics limit utilization in most centers.…”

Section: Discussionmentioning

confidence: 99%

Evolving connectionist system versus algebraic formulas for prediction of renal function from serum creatinine

Marshall

Song

Mao

et al. 2005

Kidney International

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Intra- and Interoperator Variations in Region-of-Interest Drawing and Their Effect on the Measurement of Glomerular Filtration Rates

Abstract: Spatial reproducibility in ROI drawing does not necessarily relate directly to the associated quantitative reproducibility.

Cited by 45 publications

References 6 publications

Impact of Operator on Determining Functional Parameters of Nuclear Medicine Procedures

Impact of Operator on Determining Functional Parameters of Nuclear Medicine Procedures

Semi-Automated Volumetric and Morphological Assessment of Glioblastoma Resection with Fluorescence-Guided Surgery

Evolving connectionist system versus algebraic formulas for prediction of renal function from serum creatinine

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