Intra-articular injections of platelet-rich plasma in patients with knee pain of articular cartilage origin (degenerative chondropathy and early OA)

Lee, Kyo Sun; Shetty, Asode Ananthram; Kim, Seok Jung; Kim, Young Ju; Jun, Young Joon; Choi, Nam Yong; Park, Gi Beom

doi:10.1007/s13770-013-1101-1

Cited by 1 publication

(2 citation statements)

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“…PubMed #1 "platelet-rich plasma" OR "PRP" #2 "osteoarthritis" OR "Knee osteoarthritis" OR "KOA" #3 "Mesenchymal stem cells" OR "MSCs" #4 #1 AND #2 AND #3 e quality of the literature was evaluated using the guidelines published in Cochrane handbook [16,17], in which the evaluation indicators included the following: (1) selection bias (whether the included literature belongs to RCT); (2) group hiding (whether the group adopts blinding method); (3) blind method of both doctors and patients; (4) result evaluation blind method; (5) completeness of the report results; (6) publication bias; (7) other indicators in the paper including low risk, high risk, and unclear risk.…”

Section: Database Retrievalmentioning

confidence: 99%

“…With the gradual increase of life expectancy of the population, the number of KOA occurrences is also increasing that brings a substantial economic burden to the public health and medical service. KOA has already become one of the main focuses for orthopedic surgeons with its high incidence [ 6 , 7 ]. Although nonsteroidal anti-inflammatory drugs, hyaluronic acid (HA), and steroids are most widely used for the conservative treatment of KOA, the treatment efficacy is far from satisfactory.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Intra-Articular Injection of Platelet-Rich Plasma Combined with Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Zeng

Wang²,

Liao

et al. 2022

International Journal of Clinical Practice

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Objective. This study systematically evaluated the effect of intra-articular injection of platelet-rich plasma (PRP) and mesenchymal stem cells (MSC) on knee osteoarthritis (KOA). Methods. Randomized controlled trials (RCTs) of PRP combined with MSC in the treatment of KOA were collected from PubMed, Cochrane Library, Web of Science, Wiley online library, CNKI, and Wanfang databases from inception to July 30, 2022. Two researchers read and screened the literature to extract the data, respectively. After conducting a risk-of-bias assessment of included data, RevMan 5.3 software was used for meta-analysis. The Cochrane Handbook risk-of-bias assessment tool was used to evaluate the included literature. Results. A total of 9 papers with 480 KOA patients were included in this study. Significant differences in terms of visual analogue scale (VAS) score (MD = −1.10, 95% CI −1.91 to −0.29), P = 0.008 ) and knee injury and osteoarthritis outcome score (KOOS) (MD = 4.56, 95% CI 0.54–8.58, P = 0.050 ) were noted between the 2 groups. Subgroup analysis found that MD = 1.66 in KOOS-pain-1 group (95% CI (0.10, 3.22), P = 0.040 ), which is significant. The MD for KOOS total score and IKDC scores between the two groups was MD = 6.31 (95% CI 2.73–9.88, P = 0.0005 ) and MD = 3.05 (95% CI −7.09–13.20, P = 0.56 ), respectively. Conclusion. The results of this study provide a theoretical basis for the clinical treatment of KOA with PRP combined with MSC.

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Section: Database Retrievalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%