Intra‐epithelially entrapped blood vessels in ameloblastoma

Siar, Chong Huat; Ishak, Ismadi; Ng, Kok Han

doi:10.1111/jop.12247

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…Wnts and their DKK antagonists regulate the morphology of ectodermal organs (17)(18)(19)(20). Wnt10b is a canonical Wnt member (21) that is expressed during hair induction and hair reconstitution (22,23). Recent studies have shown that adenovirus-mediated Wnt10b expression (AdWnt10b) leads to epithelial and melanocyte cell differentiation and elongated hair shafts (24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration

Lei

Guo

Qiu

et al. 2014

Experimental Dermatology

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Hair follicles have characteristic sizes corresponding to their cycle specific stage. However, how the anagen hair follicle specifies its size remains elusive. Here, we show that in response to prolonged ectopic Wnt10b-mediated β-catenin activation, regenerating anagen hair follicles grow larger in size. In particular, the hair bulb, dermal papilla and hair shaft become enlarged. While the formation of different hair types (Guard, Awl, Auchene, and Zigzag) is unaffected. Interestingly, we found the effect of exogenous WNT10b was mainly on Zigzag and less on the other kinds of hairs. We observed dramatically enhanced proliferation within the matrix, DP and hair shaft of the enlarged AdWnt10b-treated hair follicles compared with those of normal hair follicles at P98. Furthermore, expression of CD34, a specific hair stem cell marker, was increased in its number to the bulge region after AdWnt10b treatment. Ectopic expression of CD34 throughout the ORS region was also observed. Many CD34 positive hair stem cells were actively proliferating in AdWnt10b-induced hair follicles. Importantly, subsequent co-treatment with the Wnt inhibitor, DKK1, reduced hair follicle enlargement, decreased proliferation and maintained proper hair stem cell localization. Moreover, injection of DKK1 during early anagen significantly reduced the width of prospective hairs. Together, these findings strongly suggest that a balance of Wnt10b/DKK1 governs reciprocal signaling between cutaneous epithelium and mesenchyme to regulate proper hair follicle size.

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