Intra-family differences in efficacy of inactivation of small, non-enveloped viruses

Nims, Raymond W.; Zhou, Sifang

doi:10.1016/j.biologicals.2016.05.005

Cited by 21 publications

(30 citation statements)

References 30 publications

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“…As there is no cell culture‐based assay available to test the effect of disinfectants on honeybee viruses, a stable surrogate (i.e. a specific model virus), EV71, was used …”

Section: Discussionmentioning

confidence: 99%

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Virucides in apiculture: persistence of surrogate enterovirus under simulated field conditions

Prodělalová

Malenovská

Moutelíková

et al. 2017

Pest Management Science

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“…As there is no cell culture‐based assay available to test the effect of disinfectants on honeybee viruses, a stable surrogate (i.e. a specific model virus), EV71, was used …”

Section: Discussionmentioning

confidence: 99%

“…a specific model virus), EV71, was used. 34 Iodine-based disinfectants are frequently used in agriculture and veterinary medicine. Iodophors are used for general disinfection and cleaning, in bovine teat dips, and in surgical scrubs.…”

Section: Discussionmentioning

confidence: 99%

Virucides in apiculture: persistence of surrogate enterovirus under simulated field conditions

Prodělalová

Malenovská

Moutelíková

et al. 2017

Pest Management Science

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“…The nonlinear relationship displayed in the D versus temperature plot (Figures 1-3), with the steep portion of the curve at relatively lower temperatures followed by a flattening out at higher temperatures, is more informative also from a mechanism of inactivation point of view than the log 10 D versus temperature plot. If heat inactivation is attributed to capsid opening followed by nuclease destruction of genomic material [2,3], then the steep portion of the curve may represent reaching a threshold temperature required for capsid opening. Once this threshold temperature has been reached, relatively small incremental increases in temperature result in dramatic decreases in the time required for 1 log 10 inactivation.…”

Section: Our Interpretation Of Heat Inactivation Datamentioning

confidence: 99%

“…Unlike chemical inactivation approaches that often display greater efficacy for lipid-enveloped viruses than for nonenveloped viruses, heat inactivation has been found to display effectiveness for both enveloped and nonenveloped viruses [1]. Heating appears to open the viral capsid, exposing the genomic material to nucleases present in the immediate environment [2,3]. Therefore, the capsid conformation appears to be the main determinant of heat inactivation susceptibility [3,4], not the envelope status.…”

Section: Introductionmentioning

confidence: 99%

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Carrier and Liquid Heat Inactivation of Poliovirus and Adenovirus

Zhou¹,

Wilde²,

Chen³

et al. 2018

Disinfection

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Viral inactivation is typically studied using virus suspended in liquid (liquid inactivation) or virus deposited on surfaces (carrier inactivation). Carrier inactivation more closely mimics disinfection of virus contaminating a surface, while liquid inactivation mimics virus inactivation in process solutions. The prevailing opinion has been that viruses are more susceptible to heat inactivation when suspended in liquid than when deposited on surfaces. In part, this reflects a paucity of comparative studies performed in a side-by-side manner. In the present study, we investigated the relative susceptibilities of the enteroviruses poliovirus-1 and adenovirus type 5 to heat inactivation in liquid versus carrier studies. The results of our side-by-side studies suggest that these two viruses are more readily inactivated when heat is applied to virus deposited on carriers. Decimal reduction values (i.e., the amount of time required to reduce the virus titer by one log 10) measured at 46°C displayed the greatest difference between carrier and liquid inactivation approaches, with values ranging from 14.0 to 15.2 min (carrier) and from 47.4 to 64.1 min (liquid) for poliovirus. The corresponding values for adenovirus 5 were 18.2-29.2 min (carrier) and 20.8-38.3 min (liquid). At 65°C, the decimal reduction values were more similar (from 4 to 6 min) for the various inactivation approaches.

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Energy Requirements for Loss of Viral Infectivity

Rowell

Dobrovolny

2020

Food Environ Virol

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Outside the host, viruses will eventually lose their ability to infect cells due to conformational changes that occur to proteins on the viral capsid. In order to undergo a conformational change, these proteins require energy to activate the chemical reaction that leads to the conformational change. In this study, data from the literature is used to calculate the energy required for viral inactivation for a variety of different viruses by means of the Arrhenius equation. We find that some viruses (rhinovirus, poliovirus, human immunodeficiency virus, Alkhumra hemorrhagic fever virus, and hepatitis A virus) have high inactivation energies, indicative of breaking of a chemical double bond. We also find that several viruses (respiratory syncytial virus, poliovirus, and norovirus) have nonlinear Arrhenius plots, suggesting that there is more than a single pathway for inactivation of these viruses.

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Intra-family differences in efficacy of inactivation of small, non-enveloped viruses

Cited by 21 publications

References 30 publications

Virucides in apiculture: persistence of surrogate enterovirus under simulated field conditions

Virucides in apiculture: persistence of surrogate enterovirus under simulated field conditions

Carrier and Liquid Heat Inactivation of Poliovirus and Adenovirus

Energy Requirements for Loss of Viral Infectivity

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